POLA1 - DNA polymerase alpha 1, catalytic subunit Gene

中文名称：DNA 聚合酶 alpha 1，催化亚基

种属: Homo sapiens

同用名: NSX; POLA; p180; VEODS

基因 ID: 5422 | 基因类型: protein coding

关于 POLA1

Cytogenetic location: Xp22.11-p21.3 Genomic coordinates (GRCh38): X:24,693,918-24,996,986 (from NCBI)

This gene has 14 transcripts (splice variants), 197 orthologues, 3 paralogues and is associated with 7 phenotypes. Ubiquitous expression in lymph node (RPKM 2.6), bone marrow (RPKM 2.2) and 25 other tissues.

功能概要

该基因编码 DNA 聚合酶的催化亚基，它与一个调节亚基和两个引物酶亚基一起形成 DNA 聚合酶 α 复合物。催化亚基在 DNA 复制的启动中起着至关重要的作用。[RefSeq 提供，2010 年 3 月]

This gene encodes the catalytic subunit of DNA Polymerase, which together with a regulatory and two primase subunits, forms the DNA Polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication. [provided by RefSeq, Mar 2010]

POLA1 基因产物(3)

mRNA	Protein	Name
NM_001330360.2	NP_001317289.1	DNA polymerase alpha catalytic subunit isoform 1
NM_001378303.1	NP_001365232.1	DNA polymerase alpha catalytic subunit isoform 3
NM_016937.4	NP_058633.2	DNA polymerase alpha catalytic subunit isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	16762037	GOA
enables DNA-directed DNA polymerase activity	IDA IDA: 通过直接分析推断	893425	GOA
enables DNA-directed DNA polymerase activity	IMP IMP: 通过突变表型推断	4084590	GOA
enables chromatin binding	IDA IDA: 通过直接分析推断	16762037	GOA
enables nucleotide binding	IDA IDA: 通过直接分析推断	3139084	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	1311258	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	9506968	GOA
enables zinc ion binding	IDA IDA: 通过直接分析推断	26975377	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
NOT involved in DNA repair	IDA IDA: 通过直接分析推断	3335506	GOA
involved in DNA repair	IMP IMP: 通过突变表型推断	11470886	GOA
involved in DNA replication	IMP IMP: 通过突变表型推断	3917431	GOA
involved in DNA replication initiation	IDA IDA: 通过直接分析推断	2175912	GOA
involved in DNA replication, synthesis of primer	IDA IDA: 通过直接分析推断	2175912	GOA
involved in DNA strand elongation involved in DNA replication	IMP IMP: 通过突变表型推断	4084590	GOA
involved in DNA synthesis involved in DNA repair	IMP IMP: 通过突变表型推断	11470886	GOA
NOT involved in DNA synthesis involved in UV-damage excision repair	IMP IMP: 通过突变表型推断	1730053	GOA
involved in double-strand break repair via nonhomologous end joining	IMP IMP: 通过突变表型推断	11470886	GOA
involved in lagging strand elongation	IDA IDA: 通过直接分析推断	2175912	GOA
involved in leading strand elongation	IDA IDA: 通过直接分析推断	2175912	GOA
NOT involved in nucleotide-excision repair	IMP IMP: 通过突变表型推断	1508673	GOA
involved in regulation of type I interferon production	IMP IMP: 通过突变表型推断	27019227	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of alpha DNA polymerase:primase complex	IDA IDA: 通过直接分析推断	2175912	GOA
part of alpha DNA polymerase:primase complex	IPI IPI: 通过物理相互作用推断	26975377	GOA
located in chromatin	IDA IDA: 通过直接分析推断	9815285	GOA
located in cytosol	IDA IDA: 通过直接分析推断	27019227	GOA
located in nuclear envelope	IDA IDA: 通过直接分析推断	9518481	GOA
located in nuclear matrix	IDA IDA: 通过直接分析推断	1903085	GOA
located in nucleolus	IDA IDA: 通过直接分析推断	9518481	GOA
located in nucleoplasm	IDA IDA: 通过直接分析推断	7045121	GOA
located in nucleus	IDA IDA: 通过直接分析推断	4084590	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

POLA1 蛋白结构

DNA_pol_alpha_N

DNA_pol_B_exo1

DNA_pol_B

zf-DNA_Pol

0
300
600
900
1200
1462 a.a.

蛋白主名

其他名称

DNA polymerase alpha catalytic subunit

DNA polymerase alpha catalytic subunit p180

POLA1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	POLA1	P09884	lt_sv40	Simian virus 40	P03070	CoIP	8380896
种属间	POLA1	P09884	lt_sv40	Simian virus 40	P03070	Pull Down	8380896
种属间	POLA1	P09884	lt_sv40	Simian virus 40	P03070	ELISA	8648648
种属内	POLA1	P09884	RPA1	Homo sapiens	P27694	CoIP	17666013
种属间	POLA1	P09884	obp_hhv11	Human herpesvirus 1	P10193	ELISA	7644508
种属间	POLA1	P09884	obp_hhv11	Human herpesvirus 1	P10193	CoIP	7644508

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Van Esch-O'Driscoll Syndrome

X-Linked Intellectual Disability, Van Esch Type	VEODS
Mrxsveod	Mental Retardation, X-Linked, Syndromic, Van Esch-O'Driscoll Type
X-Linked Syndromic Mental Retardation Van Esch-O'Driscoll Type

Pigmentary Disorder, Reticulate, With Systemic Manifestations, X-Linked

PDR	Xlpdr
Familial Lichen Amyloidosis	Pigmentary Disorder, Reticulate, With Systemic Manifestations

Partington Syndrome

X-Linked Reticulate Pigmentary Disorder	PRTS
Partington X-Linked Mental Retardation Syndrome	Mrxs1
Mrx36	Intellectual Developmental Disorder, X-Linked, Syndromic 1
Partington Disease	Pdr
Partington-Mulley Syndrome	Russell-Silver Syndrome, X-Linked
Mental Retardation, X-Linked, Syndromic 1	Mental Retardation, X-Linked, With Dystonic Movements, Ataxia, And Seizures
Mental Retardation, X-Linked 36	X-Linked Reticulate Pigmentary Disorder With Systemic Manifestations
X-Linked Russell-Silver Syndrome	Intelectual Disability-Dystonic Movements-Ataxia-Seizures Syndrome
Intellectual Disability, X-Linked, Syndromic 1	Intellectual Disability, X-Linked, With Dystonic Movements, Ataxia, And Seizures
Partington X-Linked Intellectual Disability Syndrome	X-Linked Intellectual Deficit-Dystonia-Dysarthria
X-Linked Mental Retardation With Dystonic Movements, Ataxia, And Seizures	Familial Cutaneous Amyloidosis
X-Linked Cutaneous Amyloidosis	Xlpdr
X-Linked Intellectual Disability-Dystonia-Dysarthria Syndrome	Pigmentary Disorder, Reticulate, With Systemic Manifestations

N Syndrome

NSX	Intellectual Disability, Malformations, Chromosome Breakage, And Development Of T-Cell Leukemia

Primary Syphilis

Early Symptomatic Syphilis	Early Syphilis, Symptomatic
Symptomatic Early Syphilis

Secondary Syphilis

Syphilis, Secondary

Secondary Syphilis Of Viscera Or Bone

Early Congenital Syphilis

Latent Syphilis

Syphilis, Latent

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Congenital Syphilis

Syphilis, Congenital	Congenital Syphilis, Unspecified
Mtct Of Syphilis	Mother-To-Child Transmission Of Syphilis
Syphilis Congenital	Hereditary Syphilis
Heredosyphilis

Yaws

Frambesia	Frambesia Tropica
Bouba	Frambosie
Polypapilloma Tropicum	Thymosis
Endemic Treponematoses	Treponema Pertenue Infection
Pian	Framboesia
Framboesia Tropica	Castellani
Infection By Treponema Pertenue	Parangi
Framboesioma	Chancre Of Yaws
Primary Framboesia	Initial Lesions Of Yaws
Mother Yaw	Initial Framboesia

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-147812	POLA1 inhibitor 1	Inhibitor	98.85%	否
HY-143412	MIR002		≥99.0%	否
HY-143411	GEM144		/	否
HY-RS10816	POLA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	POLA1	MGD	MGI:99660
Bos taurus	POLA1	VGNC	VGNC:33110
Canis familiaris	POLA1	VGNC	VGNC:44771
Felis catus	POLA1	VGNC	VGNC:68934
Macaca mulatta	POLA1	VGNC	VGNC:76202
Rattus norvegicus	POLA1	RGD	RGD:621816

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

POLA1 - DNA polymerase alpha 1, catalytic subunit Gene

关于 POLA1

功能概要

POLA1 基因产物(3)

POLA1 蛋白结构

POLA1 蛋白互作信息

关联疾病

直系同源

热门区域

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POLA1 - DNA polymerase alpha 1, catalytic subunit Gene

关于 POLA1

功能概要

POLA1 基因产物(3)

POLA1 蛋白结构

POLA1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z