1. Gene
  2. PPID - peptidylprolyl isomerase D Gene

PPID - peptidylprolyl isomerase D Gene

中文名称:肽基脯氨酰异构酶 D

种属: Homo sapiens

同用名: CYPD; CYP-40

基因 ID: 5481 | 基因类型: protein coding

关于 PPID

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:158,709,127-158,723,396 (from NCBI)

This gene has 3 transcripts (splice variants), 243 orthologues and 22 paralogues. Ubiquitous expression in testis (RPKM 15.6), duodenum (RPKM 13.0) and 25 other tissues.

功能概要

该基因编码的蛋白质是肽基-脯氨酰顺反异构酶 (PPIase) 家族的成员。 PPIases 催化寡肽中脯氨酸亚胺肽键的顺反异构化,加速蛋白质的折叠。这种蛋白质已被证明具有 PPIase 活性,并且与其他家族成员相似,可以与免疫抑制剂环孢菌素 A 结合。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to Other family members, can bind to the immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]

PPID 基因产物(1)

mRNA Protein Name
NM_005038.3 NP_005029.1 peptidyl-prolyl cis-trans isomerase D
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Hsp90 protein binding IDA
IDA: 通过直接分析推断
12145316 GOA
enables heat shock protein binding IPI
IPI: 通过物理相互作用推断
9660753 GOA
enables peptidyl-prolyl cis-trans isomerase activity IDA
IDA: 通过直接分析推断
11350175 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9659917 GOA
enables transcription factor binding IDA
IDA: 通过直接分析推断
9659917 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to UV-A IMP
IMP: 通过突变表型推断
23220213 GOA
involved in chaperone-mediated protein folding IDA
IDA: 通过直接分析推断
11350175 GOA
involved in lipid droplet organization IMP
IMP: 通过突变表型推断
21711559 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
18708059 GOA
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
23220213 GOA
involved in positive regulation of protein secretion IMP
IMP: 通过突变表型推断
21711559 GOA
involved in positive regulation of viral genome replication IMP
IMP: 通过突变表型推断
19932913 GOA
involved in protein-containing complex assembly IDA
IDA: 通过直接分析推断
18708059 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11525244 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
11525244 GOA
located in nucleus IDA
IDA: 通过直接分析推断
11525244 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PPID 蛋白结构

Pro_isomerase

Pro_isomerase: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD (20 - 182)

TPR_7

TPR_7: Tetratricopeptide repeat (226 - 252)

TPR_11

TPR_11: TPR repeat (278 - 337)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
蛋白主名 其他名称

peptidyl-prolyl cis-trans isomerase D

40 kDa peptidyl-prolyl cis-trans isomerase D

PPID 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PPID Q08752 P05067-PRO_0000000093 Homo sapiens P05067-PRO_0000000093 18806802
种属内
PPID Q08752 P05067-PRO_0000000093 Homo sapiens P05067-PRO_0000000093
SPR
18806802
种属内
PPID Q08752 UROD Homo sapiens P06132 28514442
种属内
PPID Q08752 UROD Homo sapiens P06132 33961781
种属内
PPID Q08752 RACK1 Homo sapiens P63244 21146485
种属内
PPID Q08752 RACK1 Homo sapiens P63244
TAP
21146485
种属内
PPID Q08752 RPS3 Homo sapiens P23396
TAP
21146485
种属内
PPID Q08752 RPS3 Homo sapiens P23396 21146485
种属内
PPID Q08752 XRCC6 Homo sapiens P12956
TAP
21146485
种属内
PPID Q08752 XRCC6 Homo sapiens P12956 21146485
种属内
PPID Q08752 ILF2 Homo sapiens Q12905
TAP
21146485
种属内
PPID Q08752 P05067-PRO_0000000092 Homo sapiens P05067-PRO_0000000092
EM
18806802
种属内
PPID Q08752 P05067-PRO_0000000092 Homo sapiens P05067-PRO_0000000092 18806802
种属内
PPID Q08752 P05067-PRO_0000000092 Homo sapiens P05067-PRO_0000000092
SPR
18806802
种属内
PPID Q08752 P05067-PRO_0000000092 Homo sapiens P05067-PRO_0000000092 18806802
种属间
PPID Q08752 MYB Gallus gallus P01103 9659917
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PPID 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71224 PPID Protein, Human (His) Q08752 (M1-A370) ≥95%

PPID 抗体

目录号 产品名 应用 反应物种
HY-P82354 Cyclophilin 40 Antibody (YA2099) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Anaplastic Large Cell Lymphoma

Alcl

Cd30 Positive Anaplastic Large Cell Lymphoma

Ki-1 Positive Anaplastic Large Cell Lymphoma

Primary Systemic Alcl

Sacl

Ki-1+ Anaplastic Large Cell Lymphoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PPID RGD RGD:1303174
Bos taurus PPID VGNC VGNC:33197
Canis familiaris PPID VGNC VGNC:44851
Felis catus PPID VGNC VGNC:79975
Mus musculus PPID MGD MGI:1914988
Others PPID NCBI