2. Gene
  3. NAT10 - N-acetyltransferase 10 Gene

NAT10 - N-acetyltransferase 10 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：N-乙酰转移酶 10

种属: Homo sapiens

同用名: ALP; Kre33; NET43

基因 ID: 55226 | 基因类型: protein coding

关于 NAT10

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:34,105,629-34,146,908 (from NCBI)

This gene has 9 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in lymph node (RPKM 12.6), testis (RPKM 11.9) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种 RNA 胞苷乙酰转移酶，参与组蛋白乙酰化、tRNA 乙酰化、18S rRNA 的生物合成以及核结构和染色质组织的增强。[RefSeq 提供，2016 年 10 月]

The protein encoded by this gene is an RNA cytidine acetyltransferase involved in histone acetylation, tRNA acetylation, the biosynthesis of 18S rRNA, and the enhancement of nuclear architecture and chromatin organization. [provided by RefSeq, Oct 2016]

NAT10 基因产物(2)

mRNA Protein Name
NM_001144030.2 NP_001137502.2 RNA cytidine acetyltransferase isoform b
NM_024662.3 NP_078938.3 RNA cytidine acetyltransferase isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA polymerase binding IPI
IPI: 通过物理相互作用推断
18082603 GOA
enables N-acetyltransferase activity EXP
EXP: 通过实验结果推断
25411247 GOA
enables mRNA N-acetyltransferase activity IDA
IDA: 通过直接分析推断
30449621 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25653167 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of telomere maintenance via telomerase IMP
IMP: 通过突变表型推断
18082603 GOA
involved in positive regulation of translation IDA
IDA: 通过直接分析推断
30449621 GOA
involved in protein acetylation IDA
IDA: 通过直接分析推断
31722219 GOA
involved in regulation of centrosome duplication IDA
IDA: 通过直接分析推断
31722219 GOA
involved in regulation of translation IDA
IDA: 通过直接分析推断
35679869 GOA
involved in ribosomal small subunit biogenesis IDA
IDA: 通过直接分析推断
34516797 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleolus IDA
IDA: 通过直接分析推断
18082603 GOA
part of small-subunit processome IDA
IDA: 通过直接分析推断
34516797 GOA
part of telomerase holoenzyme complex IDA
IDA: 通过直接分析推断
18082603 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NAT10 蛋白结构

DUF1726

DUF1726: Domain of unknown function (DUF1726) (107 - 201)

Helicase_RecD

Helicase_RecD: Helicase (282 - 488)

GNAT_acetyltr_2

GNAT_acetyltr_2: GNAT acetyltransferase 2 (529 - 752)

tRNA_bind_2

tRNA_bind_2: Possible tRNA binding domain (771 - 890)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1025 a.a.
蛋白主名 其他名称

RNA cytidine acetyltransferase

18S rRNA cytosine acetyltransferase

NAT10 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NAT10 Q9H0A0 RPS2 Homo sapiens P15880
Crosslink
30021884
种属内
NAT10 Q9H0A0 RPS2 Homo sapiens P15880
Anti Tag CoIP
33961781
种属内
NAT10 Q9H0A0 THUMPD1 Homo sapiens Q9NXG2
Anti Bait CoIP
25653167
种属内
NAT10 Q9H0A0 THUMPD1 Homo sapiens Q9NXG2
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

NAT10 抗体

目录号 产品名 应用 反应物种
HY-P81850 NAT10 Antibody (YA1595) WB, ICC/IF, IP Human, Rat

关联疾病

疾病名称 别名
Hutchinson-Gilford Progeria Syndrome

Progeria

HGPS

Hutchinson-Gilford Syndrome

Hutchinson-Gilford Progeria

Hutchinson Gilford Syndrome

Hutchinson Gilford Progeria Syndrome

Hutchinson-Gilford Disease

Progeria Of Childhood

Hutchinson-Gilford-Progeria Syndrome
Gastric Cardia Carcinoma

Carcinoma Of Cardia Of Stomach
Microphthalmia, Syndromic 13

X-Linked Colobomatous Microphthalmia-Microcephaly-Intellectual Disability-Short Stature Syndrome

MCOPS13

Maine Microphthalmos

Colobomatous Microphthalmia With Microcephaly, Short Stature, And Psychomotor Retardation

Syndromic Microphthalmia 13

X-Linked Colobomatous Microphthalmia-Microcephaly-Short Stature-Psychomotor Retardation Syndrome

Microphthalmia, Syndromic, 13

Microphthalmia, Syndromic, Type 13
Muscular Dystrophy, Congenital, Lmna-Related

Congenital Muscular Dystrophy

Congenital Muscular Dystrophy Due To Lmna Mutation

MDCL

L-Cmd

Lmna-Related Congenital Muscular Dystrophy

Muscular Dystrophy, Congenital

Congenital Muscular Dystrophy Lmna-Related

Lmna-Related Cmd

Cmd

Mdc

Muscular Dystrophy Congenital Lmna-Related

Dystrophy, Muscular, Congenital, Lmna-Related

Dystrophy, Muscular, Congenital

Hereditary Muscular Dystrophy

Congenital Hereditary Muscular Dystrophy

Congenital Progressive Muscular Dystrophy

Hereditary Progressive Muscular Dystrophy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-16706A Remodelin hydrobromide Inhibitor 99.52% 否
HY-16706 Remodelin Inhibitor 99.79% 否
HY-120317 CPTH2-Alkyne Inhibitor / 否
HY-RS09040 NAT10 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris NAT10 VGNC VGNC:43627
Macaca mulatta NAT10 VGNC VGNC:75046
Bos taurus NAT10 VGNC VGNC:31888
Rattus norvegicus NAT10 RGD RGD:1306717
Felis catus NAT10 VGNC VGNC:63726
Mus musculus NAT10 MGD MGI:2138939
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