1. Gene
  2. METTL2B - methyltransferase 2B, methylcytidine Gene

METTL2B - methyltransferase 2B, methylcytidine Gene

中文名称:甲基转移酶 2B,甲基胞苷

种属: Homo sapiens

同用名: METL; METTL2; METTL2A; PSENIP1

基因 ID: 55798 | 基因类型: protein coding

关于 METTL2B

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:128,476,748-128,506,602 (from NCBI)

This gene has 7 transcripts (splice variants), 200 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 7.8), fat (RPKM 7.8) and 25 other tissues.

功能概要

该基因是甲基转移酶家族的成员,该家族与 UbiE 甲基转移酶家族具有同源性,但又不同。已经描述了编码不同蛋白质同种型的可变剪接变体;然而,并非所有变体都得到了充分表征。[RefSeq 提供,2008 年 7 月]

This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiE family of methyltransferases. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

METTL2B 基因产物(1)

mRNA Protein Name
NM_018396.3 NP_060866.2 tRNA N(3)-methylcytidine methyltransferase METTL2B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32427860 GOA
enables tRNA (cytidine) methyltransferase activity IMP
IMP: 通过突变表型推断
21518805 GOA
enables tRNA (cytidine-3-)-methyltransferase activity IMP
IMP: 通过突变表型推断
28655767 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in tRNA metabolic process IMP
IMP: 通过突变表型推断
28655767 GOA
involved in tRNA methylation IMP
IMP: 通过突变表型推断
21518805 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
34268557 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

METTL2B 蛋白结构

Methyltransf_23

Methyltransf_23: Methyltransferase domain (181 - 343)

  • 0
  • 100
  • 200
  • 300
  • 378 a.a.
蛋白主名 其他名称

tRNA N(3)-methylcytidine methyltransferase METTL2B

methyltransferase like 2B

直系同源

种属 基因名 来源 基因 ID
Mus musculus METTL2B MGD MGI:1289171