METTL3 - methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit Gene

中文名称：甲基转移酶 3，N6-腺苷-甲基转移酶复合催化亚基

种属: Homo sapiens

同用名: M6A; IME4; Spo8; MT-A70; hMETTL3

基因 ID: 56339 | 基因类型: protein coding

关于 METTL3

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:21,498,138-21,511,340 (from NCBI)

This gene has 14 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in lymph node (RPKM 23.5), testis (RPKM 22.1) and 25 other tissues.

功能概要

该基因编码 MT-A 的 70 kDa 亚基，它是 N6-腺苷-甲基转移酶的一部分。该酶参与真核 mRNA 中内部腺苷残基的转录后甲基化，形成 N6-甲基腺苷。[RefSeq 提供，2008 年 7 月]

This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This Enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. [provided by RefSeq, Jul 2008]

METTL3 基因产物(1)

mRNA	Protein	Name
NM_019852.5	NP_062826.2	N6-adenosine-methyltransferase catalytic subunit

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA methyltransferase activity	IDA IDA: 通过直接分析推断	25799998	GOA
enables S-adenosyl-L-methionine binding	IDA IDA: 通过直接分析推断	27281194	GOA
enables mRNA binding	IDA IDA: 通过直接分析推断	27281194	GOA
enables mRNA m(6)A methyltransferase activity	IDA IDA: 通过直接分析推断	24316715	GOA
enables mRNA m(6)A methyltransferase activity	IMP IMP: 通过突变表型推断	9409616	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	24316715	GOA
enables protein heterodimerization activity	IDA IDA: 通过直接分析推断	27373337	GOA
enables protein heterodimerization activity	IPI IPI: 通过物理相互作用推断	27281194	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage response	IDA IDA: 通过直接分析推断	28297716	GOA
involved in RNA methylation	IMP IMP: 通过突变表型推断	9409616	GOA
involved in cellular response to UV	IDA IDA: 通过直接分析推断	28297716	GOA
involved in dosage compensation by inactivation of X chromosome	IDA IDA: 通过直接分析推断	27602518	GOA
involved in mRNA modification	IDA IDA: 通过直接分析推断	27373337	GOA
involved in mRNA processing	IDA IDA: 通过直接分析推断	24316715	GOA
involved in mRNA processing	IMP IMP: 通过突变表型推断	22575960	GOA
involved in mRNA splicing, via spliceosome	IMP IMP: 通过突变表型推断	25719671	GOA
involved in negative regulation of type I interferon-mediated signaling pathway	IMP IMP: 通过突变表型推断	30559377	GOA
involved in positive regulation of cap-independent translational initiation	IMP IMP: 通过突变表型推断	26593424	GOA
involved in positive regulation of translation	IMP IMP: 通过突变表型推断	30559377	GOA
involved in primary miRNA processing	IDA IDA: 通过直接分析推断	25799998	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of RNA N6-methyladenosine methyltransferase complex	IDA IDA: 通过直接分析推断	24316715	GOA
part of RNA N6-methyladenosine methyltransferase complex	IPI IPI: 通过物理相互作用推断	29507755	GOA
located in nuclear speck	IDA IDA: 通过直接分析推断	24407421	GOA
located in nucleus	IDA IDA: 通过直接分析推断	9409616	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

METTL3 蛋白结构

MT-A70

0
100
200
300
400
500
580 a.a.

蛋白主名

其他名称

N6-adenosine-methyltransferase catalytic subunit

N6-adenosine-methyltransferase 70 kDa subunit

METTL3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	METTL3	Q86U44	METTL14	Homo sapiens	Q9HCE5	Anti Tag CoIP	29507755
种属内	METTL3	Q86U44	METTL14	Homo sapiens	Q9HCE5	X-Ray Diffraction	27373337
种属内	METTL3	Q86U44	METTL14	Homo sapiens	Q9HCE5	Radiolabeled Methyl	27373337
种属内	METTL3	Q86U44	METTL14	Homo sapiens	Q9HCE5	Anti Tag CoIP	26496610

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Bladder Urothelial Carcinoma

Bladder Transitional Cell Carcinoma	Transitional Cell Carcinoma Of Bladder
Transitional Cell Carcinoma Of The Bladder	Urinary Bladder Urothelial Carcinoma
Urothelial Bladder Carcinoma	Carcinoma Transitional Cell Bladder
Tcc - [Transitional Cell Carcinoma] Of Bladder

Hepatoblastoma

Colon Adenocarcinoma

Adenocarcinoma Of Colon	Adenocarcinoma Of The Colon
Colonic Adenocarcinoma

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Ocular Melanoma

Intraocular Melanoma	Uveal Melanoma
Eye Melanoma	Melanoma Of Eye
Melanoma Of The Uvea	Malignant Melanoma Of Eye

Retinitis Pigmentosa 11

RP11	Retinitis Pigmentosa-11
Retinitis Pigmentosa, Type 11

Cervix Carcinoma

Cancer Of Cervix	Carcinoma Of Cervix
Carcinoma Cervix Uteri	Carcinoma Of The Cervix Uteri

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-156677	STC-15	Inhibitor	99.90%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-134836	STM2457	Inhibitor	99.86%	否
HY-115717	UZH2	Inhibitor	98.73%	否
HY-162080	METTL1-WDR4-IN-1	Inhibitor	98.87%	否
HY-160415A	WD6305 TFA	Inhibitor	99.81%	否
HY-153625	STM2120	Inhibitor	99.92%	否
HY-134673B	UZH1b	Inhibitor	99.75%	否
HY-P10387A	RSM3 TFA	Inhibitor	/	否
HY-158403	METTL3-IN-7	Inhibitor	/	否
HY-159604	METTL3-IN-9	Inhibitor	/	否
HY-148467	METTL3-IN-1	Inhibitor	/	否
HY-148468	METTL3-IN-2	Inhibitor	/	否
HY-158404	METTL3-IN-8	Inhibitor	/	否
HY-154997	7OQL	Inhibitor	/	否
HY-156759	METTL3-IN-5	Inhibitor	/	否
HY-148469	METTL3-IN-3	Inhibitor	/	否
HY-W125425	Methyl piperazine-2-carboxylate	Activator	/	否
HY-P10387	RSM3	Inhibitor	/	否
HY-168878	EP652	Inhibitor	/	否
HY-160415	WD6305	Inhibitor	/	否
HY-162930	PROTAC METTL3 degrader 1	Degrader	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	METTL3	VGNC	VGNC:63465
Mus musculus	METTL3	MGD	MGI:1927165
Rattus norvegicus	METTL3	RGD	RGD:1311750
Canis familiaris	METTL3	VGNC	VGNC:43177
Bos taurus	METTL3	VGNC	VGNC:31412
Others	METTL3	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4