METTL14 - methyltransferase 14, N6-adenosine-methyltransferase subunit Gene

中文名称：甲基转移酶 14，N6-腺苷甲基转移酶亚基

种属: Homo sapiens

同用名: hMETTL14

基因 ID: 57721 | 基因类型: protein coding

关于 METTL14

Cytogenetic location: 4q26 Genomic coordinates (GRCh38): 4:118,685,392-118,715,430 (from NCBI)

This gene has 6 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in testis (RPKM 8.4), thyroid (RPKM 7.2) and 25 other tissues.

功能概要

启用 mRNA 结合活性。有助于 mRNA (2'-O-甲基腺苷-N6-) -甲基转移酶活性。参与 mRNA 代谢过程；造血祖细胞分化的负调控；和翻译的积极调节。位于核质中。 RNA N6-甲基腺苷甲基转移酶复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables mRNA binding activity. Contributes to mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity. Involved in mRNA metabolic process; negative regulation of hematopoietic progenitor cell differentiation; and positive regulation of translation. Located in nucleoplasm. Part of RNA N6-methyladenosine methyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

METTL14 基因产物(1)

mRNA	Protein	Name
NM_020961.4	NP_066012.1	N6-adenosine-methyltransferase non-catalytic subunit

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
NOT enables S-adenosyl-L-methionine binding	IDA IDA: 通过直接分析推断	27281194	GOA
enables mRNA binding	IDA IDA: 通过直接分析推断	27281194	GOA
NOT enables mRNA m(6)A methyltransferase activity	IDA IDA: 通过直接分析推断	27627798	GOA
enables mRNA m(6)A methyltransferase activity	IDA IDA: 通过直接分析推断	24316715	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	24316715	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in mRNA modification	IDA IDA: 通过直接分析推断	27281194	GOA
involved in mRNA processing	IDA IDA: 通过直接分析推断	27281194	GOA
involved in mRNA processing	IMP IMP: 通过突变表型推断	24316715	GOA
involved in mRNA splicing, via spliceosome	IMP IMP: 通过突变表型推断	25719671	GOA
involved in mRNA stabilization	IDA IDA: 通过直接分析推断	29290617	GOA
acts upstream of negative regulation of hematopoietic progenitor cell differentiation	IMP IMP: 通过突变表型推断	29290617	GOA
acts upstream of positive regulation of translation	IMP IMP: 通过突变表型推断	29290617	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of RNA N6-methyladenosine methyltransferase complex	IDA IDA: 通过直接分析推断	24316715	GOA
part of RNA N6-methyladenosine methyltransferase complex	IPI IPI: 通过物理相互作用推断	29507755	GOA
located in nucleus	IDA IDA: 通过直接分析推断	24316715	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

METTL14 蛋白结构

MT-A70

0
100
200
300
400
456 a.a.

蛋白主名

其他名称

N6-adenosine-methyltransferase non-catalytic subunit

N6-adenosine-methyltransferase subunit METTL14

METTL14 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	METTL14	Q9HCE5	METTL3	Homo sapiens	Q86U44	GMS	27373337
种属内	METTL14	Q9HCE5	METTL3	Homo sapiens	Q86U44	Comig Non-Denat Gel	24316715
种属内	METTL14	Q9HCE5	METTL3	Homo sapiens	Q86U44	Pull Down	24394384
种属内	METTL14	Q9HCE5	METTL3	Homo sapiens	Q86U44	Anti Tag CoIP	33961781
种属内	METTL14	Q9HCE5	METTL3	Homo sapiens	Q86U44	Anti Tag CoIP	24316715
种属内	METTL14	Q9HCE5	METTL3	Homo sapiens	Q86U44	Anti Tag CoIP	29507755
种属内	METTL14	Q9HCE5	METTL3	Homo sapiens	Q86U44	X-Ray Diffraction	27373337
种属内	METTL14	Q9HCE5	METTL3	Homo sapiens	Q86U44-1	Anti Tag CoIP	24316715
种属内	METTL14	Q9HCE5	METTL3	Homo sapiens	Q86U44-1	GMS	24316715
种属内	METTL14	Q9HCE5	WTAP	Homo sapiens	Q15007-1	Anti Tag CoIP	24316715
种属内	METTL14	Q9HCE5	WTAP	Homo sapiens	Q15007-1	GMS	24316715

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hepatoblastoma

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-19528	SAH		99.89%	否
HY-160415A	WD6305 TFA		99.81%	否
HY-19528S	SAH-d4		≥99.0%	否
HY-153625	STM2120	Inhibitor	99.92%	否
HY-RS08355	METTL14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-151926	Antiviral agent 24	Inhibitor	99.63%	否
HY-19528S2	SAH-13C10		99.90%	否
HY-P10387A	RSM3 TFA		/	否
HY-151924	Antiviral agent 23	Inhibitor	/	否
HY-160415	WD6305		/	否
HY-162282	PROTAC METTL3-14 degrader 1	Degrader	/	否
HY-19528S1	SAH-13C5		/	否
HY-P10387	RSM3		/	否
HY-W125425	Methyl piperazine-2-carboxylate	Activator	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	METTL14	VGNC	VGNC:63459
Canis familiaris	METTL14	VGNC	VGNC:43171
Macaca mulatta	METTL14	VGNC	VGNC:74612
Mus musculus	METTL14	MGD	MGI:2442926
Bos taurus	METTL14	VGNC	VGNC:31404
Rattus norvegicus	METTL14	RGD	RGD:1304822
Others	METTL14	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

METTL14 - methyltransferase 14, N6-adenosine-methyltransferase subunit Gene

关于 METTL14

功能概要

METTL14 基因产物(1)

METTL14 蛋白结构

METTL14 蛋白互作信息

关联疾病

直系同源

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METTL14 - methyltransferase 14, N6-adenosine-methyltransferase subunit Gene

关于 METTL14

功能概要

METTL14 基因产物(1)

METTL14 蛋白结构

METTL14 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z