2. Gene
  3. PCNP - PEST proteolytic signal containing nuclear protein Gene

PCNP - PEST proteolytic signal containing nuclear protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含核蛋白的 PEST 蛋白水解信号

种属: Homo sapiens

基因 ID: 57092 | 基因类型: protein coding

关于 PCNP

Cytogenetic location: 3q12.3 Genomic coordinates (GRCh38): 3:101,574,094-101,594,465 (from NCBI)

This gene has 8 transcripts (splice variants) and 187 orthologues. Ubiquitous expression in ovary (RPKM 78.0), thyroid (RPKM 65.5) and 25 other tissues.

功能概要

参与蛋白酶体介导的泛素依赖性蛋白质分解代谢过程和蛋白质泛素化。位于核体。 [由基因组资源联盟提供，2022 年 4 月]

Involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

PCNP 基因产物(7)

mRNA Protein Name
NM_001320395.1 NP_001307324.1 PEST proteolytic signal-containing nuclear protein isoform b
NM_001320397.1 NP_001307326.1 PEST proteolytic signal-containing nuclear protein isoform c
NM_001320398.1 NP_001307327.1 PEST proteolytic signal-containing nuclear protein isoform d
NM_001320399.1 NP_001307328.1 PEST proteolytic signal-containing nuclear protein isoform e
NM_001320400.1 NP_001307329.1 PEST proteolytic signal-containing nuclear protein isoform f
NM_001320401.1 NP_001307330.1 PEST proteolytic signal-containing nuclear protein isoform g
NM_020357.3 NP_065090.1 PEST proteolytic signal-containing nuclear protein isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12176013 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
14741369 GOA
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
14741369 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
12176013 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PCNP 蛋白结构

PCNP

PCNP: PEST, proteolytic signal-containing nuclear protein family (22 - 167)

  • 0
  • 100
  • 178 a.a.
蛋白主名 其他名称

PEST proteolytic signal-containing nuclear protein

PEST-containing nuclear protein

PCNP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PCNP Q8WW12 KLK6 Homo sapiens Q92876
Validated Y2H
32814053
种属内
PCNP Q8WW12 KLK6 Homo sapiens Q92876
Y2H Array
32814053
种属内
PCNP Q8WW12 KLK6 Homo sapiens Q92876
Y2H Pooling
32814053
种属内
PCNP Q8WW12 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
种属内
PCNP Q8WW12 TERF2IP Homo sapiens Q9NYB0
BiFC
21044950
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Venezuelan Hemorrhagic Fever

Guanarito Hemorrhagic Fever

Vehf - [Venezuelan Haemorrhagic Fever]
Hereditary Lymphedema I

Lymphedema

Hereditary Lymphedema Type I

Congenital Primary Lymphedema

Lmph1

Milroy Disease

Nonne-Milroy Lymphedema

Pcl

Lymphedema Hereditary Type 1
Hereditary Lymphedema

Milroy Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10160 PCNP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PCNP RGD RGD:1563775
Bos taurus PCNP VGNC VGNC:32636
Felis catus PCNP VGNC VGNC:102801
Canis familiaris PCNP VGNC VGNC:44311
Mus musculus PCNP MGD MGI:1923552
Macaca mulatta PCNP VGNC VGNC:84059
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