2. Gene
  3. ADGRB3 - adhesion G protein-coupled receptor B3 Gene

ADGRB3 - adhesion G protein-coupled receptor B3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：粘附 G 蛋白偶联受体 B3

种属: Homo sapiens

同用名: BAI3

基因 ID: 577 | 基因类型: protein coding

关于 ADGRB3

Cytogenetic location: 6q12-q13 Genomic coordinates (GRCh38): 6:68,635,282-69,389,506 (from NCBI)

This gene has 6 transcripts (splice variants), 216 orthologues and 42 paralogues. Biased expression in brain (RPKM 7.6), adrenal (RPKM 0.8) and 3 other tissues.

功能概要

这种 p53 靶基因编码一种脑特异性血管生成抑制剂，一种七跨度跨膜蛋白，被认为是分泌素受体家族的成员。脑特异性血管生成蛋白 BAI2 和 BAI3 在结构上与 BAI1 相似，具有相似的组织特异性，也可能在血管生成中发挥作用。[RefSeq 提供，2008 年 7 月]

This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the Secretin Receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis. [provided by RefSeq, Jul 2008]

ADGRB3 基因产物(1)

mRNA Protein Name
NM_001704.3 NP_001695.2 adhesion G protein-coupled receptor B3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21262840 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in myoblast fusion IDA
IDA: 通过直接分析推断
24567399 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IPI
IPI: 通过物理相互作用推断
21262840 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADGRB3 蛋白结构

TSP_1

TSP_1: Thrombospondin type 1 domain (296 - 342)

TSP_1

TSP_1: Thrombospondin type 1 domain (350 - 397)

TSP_1

TSP_1: Thrombospondin type 1 domain (405 - 452)

TSP_1

TSP_1: Thrombospondin type 1 domain (460 - 507)

HRM

HRM: Hormone receptor domain (512 - 570)

(586 - 806)

GPS

GPS: GPCR proteolysis site, GPS, motif (816 - 862)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (877 - 1143)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1522 a.a.
蛋白主名 其他名称

adhesion G protein-coupled receptor B3

brain-specific angiogenesis inhibitor 3

ADGRB3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ADGRB3 O60242 TLCD4 Homo sapiens Q96MV1
Y2H Prey Pooling
32296183
种属内
ADGRB3 O60242 TLCD4 Homo sapiens Q96MV1
Y2H Array
32296183
种属内
ADGRB3 O60242 TLCD4 Homo sapiens Q96MV1
Validated Y2H
32296183
种属间
ADGRB3 O60242 C1ql3 Mus musculus Q9ESN4
SPR
21262840
种属间
ADGRB3 O60242 C1ql3 Mus musculus Q9ESN4
Pull Down
21262840
种属间
ADGRB3 O60242 C1ql3 Mus musculus Q9ESN4
Anti Tag CoIP
21262840
种属内
ADGRB3 O60242 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
种属内
ADGRB3 O60242 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
种属内
ADGRB3 O60242 MUC1 Homo sapiens P15941-11
Validated Y2H
32296183
种属内
ADGRB3 O60242 GPATCH11 Homo sapiens Q8N954
Validated Y2H
25416956
种属内
ADGRB3 O60242 GPR37L1 Homo sapiens O60883
Validated Y2H
32296183
种属内
ADGRB3 O60242 GPR37L1 Homo sapiens O60883
Y2H Array
32296183
种属内
ADGRB3 O60242 GPR37L1 Homo sapiens O60883
Y2H Prey Pooling
32296183
种属内
ADGRB3 O60242 SLC7A1 Homo sapiens P30825
Y2H Prey Pooling
32296183
种属内
ADGRB3 O60242 SLC7A1 Homo sapiens P30825
Validated Y2H
32296183
种属内
ADGRB3 O60242 SLC7A1 Homo sapiens P30825
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ADGRB3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7675 BAI3 Protein, Human (HEK293, His) O60242 (A25-T880) ≥95%

关联疾病

疾病名称 别名
Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria

BFPP

Cerebellar Ataxia With Neuronal Migration Defect
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Carey-Fineman-Ziter Syndrome 1

Carey-Fineman-Ziter Syndrome

CFZS

Congenital Nonprogressive Myopathy With Moebius And Robin Sequences

Myopathy, Congenital Nonprogressive, With Moebius Sequence And Robin Sequence

Cfz Syndrome

Carey Fineman Ziter Syndrome

Myopathy, Congenital Nonprogressive With Moebius And Robin Sequences

Myopathy-Moebius-Robin Syndrome

CFZS1

Moebius Sequence, Robin Complex, And Hypotonia

Congenital Non-Progressive Myopathy With Moebius And Robin Sequences
Usher Syndrome, Type Iic

Usher Syndrome Type 2c

USH2C

Usher Syndrome, Type 2c

Usher Syndrome, Type Iic, Gpr98/Pdzd7 Digenic

Usher Syndrome Type Iic

Usher Syndrome, Type 2c, Gpr98/Pdzd7 Digenic

Usher Syndrome 2c

Usher'S Syndrome Type 2c

Usher Syndrome Type Iic Gpr98/Pdzd7 Digenic
Vibratory Urticaria

Vibratory Angioedema

Dermodistortive Urticaria

VBU

Ddu

Angioedema, Vibratory
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00347 ADGRB3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus ADGRB3 VGNC VGNC:59318
Felis catus ADGRB3 VGNC VGNC:69077
Canis familiaris ADGRB3 VGNC VGNC:37635
Rattus norvegicus ADGRB3 RGD RGD:1309703
Macaca mulatta ADGRB3 VGNC VGNC:81006
Mus musculus ADGRB3 MGD MGI:2441837
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