MARK4 - microtubule affinity regulating kinase 4 Gene

中文名称：微管亲和力调节激酶 4

种属: Homo sapiens

同用名: MARK4L; MARK4S; MARKL1; PAR-1D; MARKL1L

基因 ID: 57787 | 基因类型: protein coding

关于 MARK4

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,251,271-45,305,284 (from NCBI)

This gene has 9 transcripts (splice variants), 270 orthologues and 3 paralogues. Broad expression in testis (RPKM 14.0), brain (RPKM 8.1) and 25 other tissues.

功能概要

该基因编码微管亲和力调节激酶家族的成员。这些蛋白激酶磷酸化微管相关蛋白并调节稳定和动态微管之间的转换。编码的蛋白质在整个有丝分裂过程中与中心体相关，并可能参与细胞周期控制。该基因的表达是癌症的潜在标志物，编码的蛋白质也可能在阿尔茨海默病中发挥作用。该基因的假基因位于 3 号染色体的短臂和长臂上。已经观察到该基因编码多种亚型的选择性剪接转录物变体。[RefSeq 提供，2010 年 12 月]

This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for Cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

MARK4 基因产物(2)

mRNA	Protein	Name
NM_001199867.2	NP_001186796.1	MAP/microtubule affinity-regulating kinase 4 isoform 1
NM_031417.4	NP_113605.2	MAP/microtubule affinity-regulating kinase 4 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cytoskeletal anchor activity	IDA IDA: 通过直接分析推断	28656979	GOA
enables gamma-tubulin binding	IDA IDA: 通过直接分析推断	14594945	GOA
enables microtubule binding	IDA IDA: 通过直接分析推断	14594945	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	14594945	GOA
enables tau-protein kinase activity	IDA IDA: 通过直接分析推断	14594945	GOA
enables tau-protein kinase activity	IMP IMP: 通过突变表型推断	23666762	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cilium organization	IGI IGI: 通过遗传相互作用推断	23400999	GOA
involved in microtubule bundle formation	IEP IEP: 通过表达模式推断	14594945	GOA
NOT involved in microtubule cytoskeleton organization	IMP IMP: 通过突变表型推断	23400999	GOA
involved in microtubule cytoskeleton organization	IMP IMP: 通过突变表型推断	14594945	GOA
involved in nervous system development	IDA IDA: 通过直接分析推断	14594945	GOA
involved in positive regulation of NLRP3 inflammasome complex assembly	IDA IDA: 通过直接分析推断	28656979	GOA
acts upstream of or within positive regulation of cell cycle	IDA IDA: 通过直接分析推断	26882547	GOA
involved in positive regulation of cilium assembly	IMP IMP: 通过突变表型推断	23400999	GOA
involved in positive regulation of protein localization to centrosome	IMP IMP: 通过突变表型推断	23400999	GOA
involved in protein phosphorylation	IMP IMP: 通过突变表型推断	23666762	GOA
involved in regulation of centrosome cycle	IMP IMP: 通过突变表型推断	25123532	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in centrosome	IDA IDA: 通过直接分析推断	14594945	GOA
located in ciliary basal body	IMP IMP: 通过突变表型推断	23400999	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	23666762	GOA
located in dendrite	IDA IDA: 通过直接分析推断	23666762	GOA
part of gamma-tubulin complex	IDA IDA: 通过直接分析推断	25123532	GOA
located in microtubule cytoskeleton	IDA IDA: 通过直接分析推断	14594945	GOA
is active in microtubule organizing center	IDA IDA: 通过直接分析推断	28656979	GOA
located in microtubule organizing center	IDA IDA: 通过直接分析推断	14594945	GOA
located in midbody	IDA IDA: 通过直接分析推断	25123532	GOA
located in neuron projection	IDA IDA: 通过直接分析推断	14594945	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MARK4 蛋白结构

Pkinase

UBA

KA1

0
200
400
600
752 a.a.

蛋白主名

其他名称

MAP/microtubule affinity-regulating kinase 4

MAP/microtubule affinity-regulating kinase like 1

MARK4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	MARK4	Q96L34	PRKCI	Homo sapiens	P41743	Anti Tag CoIP	14676191
Intra	MARK4	Q96L34	PARD6G	Homo sapiens	Q9BYG4	Anti Tag CoIP	14676191
Intra	MARK4	Q96L34	PNMA1	Homo sapiens	Q8ND90	Anti Tag CoIP	14676191
Intra	MARK4	Q96L34	TUBG1	Homo sapiens	P23258	Anti Tag CoIP	14676191
Intra	MARK4	Q96L34	TUBG1	Homo sapiens	P23258	Anti Tag CoIP	14594945
Intra	MARK4	Q96L34	TUBG1	Homo sapiens	P23258	TAP	14594945
Intra	MARK4	Q96L34	STK11	Homo sapiens	Q15831	Anti Tag CoIP	14676191
Intra	MARK4	Q96L34	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	14676191
Intra	MARK4	Q96L34	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	16959763
Intra	MARK4	Q96L34	LYN	Homo sapiens	P07948	Validated Y2H	32814053
Intra	MARK4	Q96L34	LYN	Homo sapiens	P07948	Y2H Array	32814053
Intra	MARK4	Q96L34	LYN	Homo sapiens	P07948	Y2H Pooling	32814053
Intra	MARK4	Q96L34	CDC42	Homo sapiens	P60953	Anti Tag CoIP	14676191
Intra	MARK4	Q96L34	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956
Intra	MARK4	Q96L34	KRT31	Homo sapiens	Q15323	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Peutz-Jeghers Syndrome

PJS	Polyposis, Hamartomatous Intestinal
Polyps-And-Spots Syndrome	Lentiginosis, Perioral
Periorificial Lentiginosis Syndrome	Hamartomatous Intestinal Polyposis
Hamartomatous Polyp	Colonic Hamartomatous Polyp
Gastric Peutz-Jeghers Polyp	Peutz Jeghers Colon Polyp
Peutz Jeghers Polyp	Peutz-Jeghers Polyp Of Small Intestine
Peutz-Jeghers Small Bowel Hamartoma	Peutz Jeghers Polyposis
Intestinal Polyposis-Cutaneous Pigmentation Syndrome	Peutz-Jeghers Polyposis
Polyposis, Intestinal, Ii	Intestinal Hamartomatous Polyposis
Peutz-Jeghers Polyp	Peutz-Jeghers Polyp Of The Stomach
Peutz Jehgers Polyp	Peutz-Jeghers Polyps Of Small Bowel

Parkinson Disease 6, Autosomal Recessive Early-Onset

Autosomal Recessive Early-Onset Parkinson Disease 6	Parkinson Disease 6
PARK6	Parkinson Disease 6, Early Onset
Parkinson'S Disease 6	Parkinson Disease 6, Early-Onset
Autosomal Recessive Early-Onset Parkinson'S Disease 6	Early-Onset Parkinson Disease 6
Autosomal Recessive Early-Onset Parkinson Disease Type 6	Parkinson Disease 6 Early-Onset
Parkinson Disease 6 Late-Onset Susceptibility To	Parkinson Disease Autosomal Recessive Early-Onset Digenic Pink1/Dj1
Parkinsonism Young Adult Onset	Parkinson Disease, Autosomal Recessive Early-Onset, Digenic, Pink1/Dj1
Parkinson Disease, Type 6, Autosomal Recessive, Early-Onset

Alzheimer'S Disease 1

Alzheimer Disease Type 1

Alzheimer'S Disease 1, Early Onset

Hermansky-Pudlak Syndrome 1

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells	HPS1
Delta Storage Pool Disease	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial
Hermansky-Pudlak Syndrome, Type 1	Platelet Storage Pool Deficiency

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-139604	PCC0208017		98.03%	否
HY-114317	MARK4 inhibitor 1		98.29%	否
HY-148062	RSS0680		98.03%	否
HY-154988	MARK4 inhibitor 4		99.23%	否
HY-154986	MARK4 inhibitor 2	Inhibitor	99.47%	否
HY-148065	FMF-06-098-1		/	否
HY-154987	MARK4 inhibitor 3		98.23%	否
HY-RS08152	MARK4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	MARK4	VGNC	VGNC:74508
Bos taurus	MARK4	VGNC	VGNC:52203
Mus musculus	MARK4	MGD	MGI:1920955
Canis familiaris	MARK4	VGNC	VGNC:43026
Rattus norvegicus	MARK4	RGD	RGD:1591792
Felis catus	MARK4	VGNC	VGNC:63390
Others	MARK4	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MARK4 - microtubule affinity regulating kinase 4 Gene

关于 MARK4

功能概要

MARK4 基因产物(2)

MARK4 蛋白结构

MARK4 蛋白互作信息

关联疾病

直系同源

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MARK4 - microtubule affinity regulating kinase 4 Gene

关于 MARK4

功能概要

MARK4 基因产物(2)

MARK4 蛋白结构

MARK4 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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C

F

G

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J

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Q

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