2. Cell Cycle/DNA Damage PI3K/Akt/mTOR Epigenetics Apoptosis
  3. MARK AMPK Apoptosis
  4. MARK4 inhibitor 1

MARK4 inhibitor 1 

目录号: HY-114317 纯度: 98.29%
COA 产品使用指南

摩尔计算器

MARK4 inhibitor 1 是有效的选择性的 MARK4 的抑制剂，IC50 值为1.54 μM。MARK4 inhibitor 1抑制癌细胞增殖、转移，诱导凋亡 (apoptosis)。

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MARK4 inhibitor 1 Chemical Structure

MARK4 inhibitor 1 Chemical Structure

CAS No. : 2271081-58-2

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规格 价格 是否有货 数量
1 mg ￥1257
In-stock
5 mg ￥2200
In-stock
10 mg ￥4100
In-stock
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Customer Review

MARK4 inhibitor 1 相关抗体

Top Publications Citing Use of Products

查看 AMPK 亚型特异性产品:

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MARK4 inhibitor 1 is a potent and selective microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC50 of 1.54 μM. MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis[1].

IC50 & Target

IC50: 1.54 μM (MARK4)[1].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
200 μM
Compound: 9g
Antiproliferative activity against human HEK293 cells assessed as cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HEK293 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 30579124]
HepG2 IC50
8.14 μM
Compound: 9g
Antiproliferative activity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 30579124]
MCF7 IC50
6.22 μM
Compound: 9g
Antiproliferative activity against human MCF7 cells assessed as cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 30579124]
MDA-MB-435S IC50
9.94 μM
Compound: 9g
Antiproliferative activity against human MDA-MB-435S cells assessed as cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-435S cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 30579124]
体外研究
(In Vitro)

MARK4 inhibitor 1 (化合物 9g；0-200 µM；24-48 小时) 可抑制细胞增殖和细胞迁移[1]。
MARK4 inhibitor 1 (化合物9g；24) 诱导这些癌细胞凋亡，IC50 值分别为 6.22 μM、9.94 μM 和 8.14 μM。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MARK4 inhibitor 1 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MCF-7, MDA-MB-435s and HepG2 cells
Concentration: 0-200 µM
Incubation Time: 24 and 48 h
Result: Decreased the viability of these cells in a concentration dependent manner.
分子量

390.40

Formula

C20H18N6O3
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 5 mg/mL (12.81 mM; 超声助溶; 酸性条件溶解 (HCL 调节，pH≈2); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5615 mL 12.8074 mL 25.6148 mL
5 mM 0.5123 mL 2.5615 mL 5.1230 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.29%

COA (197 KB) HNMR (217 KB) LCMS (134 KB)

产品使用指南 (1538 KB)
参考文献

MARK4 inhibitor 1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5615 mL 12.8074 mL 25.6148 mL 64.0369 mL
5 mM 0.5123 mL 2.5615 mL 5.1230 mL 12.8074 mL
10 mM 0.2561 mL 1.2807 mL 2.5615 mL 6.4037 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MARK4 inhibitor 12271081-58-2MARKAMPKApoptosisMicrotubule affinity regulating kinaseAMP-activated protein kinaseInhibitorinhibitorinhibit

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