1. Gene
  2. TUBG1 - tubulin gamma 1 Gene

TUBG1 - tubulin gamma 1 Gene

中文名称:微管蛋白γ1

种属: Homo sapiens

同用名: TUBG; GCP-1; CDCBM4; TUBGCP1

基因 ID: 7283 | 基因类型: protein coding

关于 TUBG1

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:42,609,683-42,615,238 (from NCBI)

This gene has 14 transcripts (splice variants), 193 orthologues, 23 paralogues and is associated with 3 phenotypes. Broad expression in testis (RPKM 90.1), bone marrow (RPKM 18.5) and 23 other tissues.

功能概要

该基因编码微管蛋白超家族的一个成员。编码的蛋白质定位于中心体,在那里它与微管结合,作为称为 γ-微管蛋白环复合体的复合体的一部分。该蛋白介导微管成核,是微管形成和细胞周期进程所必需的。在 7 号染色体上发现了该基因的假基因。[RefSeq 提供,2009 年 1 月]

This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7. [provided by RefSeq, Jan 2009]

TUBG1 基因产物(1)

mRNA Protein Name
NM_001070.5 NP_001061.2 tubulin gamma-1 chain

TUBG1 蛋白结构

Tubulin

Tubulin: Tubulin/FtsZ family, GTPase domain (4 - 226)

Tubulin_C

Tubulin_C: Tubulin C-terminal domain (264 - 392)

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  • 451 a.a.
蛋白主名 其他名称

tubulin gamma-1 chain

gamma-tubulin complex component 1

TUBG1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TUBG1 P23258 MZT2B Homo sapiens Q6NZ67
Pull Down
29568061
Intra TUBG1 P23258 MZT2B Homo sapiens Q6NZ67
Density Sedimentation
20360068
Intra TUBG1 P23258 TUBGCP4 Homo sapiens Q9UGJ1-2
Anti Tag CoIP
26496610
Intra TUBG1 P23258 MARK4 Homo sapiens Q96L34
Anti Tag CoIP
14594945
Intra TUBG1 P23258 TUBGCP3 Homo sapiens Q96CW5
TAP
20360068
Intra TUBG1 P23258 TUBGCP2 Homo sapiens Q9BSJ2
Anti Tag CoIP
26496610
Intra TUBG1 P23258 TUBGCP3 Homo sapiens Q96CW5
Anti Tag CoIP
27015882
Intra TUBG1 P23258 TUBGCP3 Homo sapiens Q96CW5
Pull Down
29568061
Intra TUBG1 P23258 TUBGCP2 Homo sapiens Q9BSJ2
TAP
20360068
Intra TUBG1 P23258 TUBGCP2 Homo sapiens Q9BSJ2
Anti Tag CoIP
27015882
Intra TUBG1 P23258 TUBGCP3 Homo sapiens Q96CW5
Anti Tag CoIP
35271311
Intra TUBG1 P23258 TUBGCP5 Homo sapiens Q96RT8
Anti Tag CoIP
26496610
Intra TUBG1 P23258 TUBGCP2 Homo sapiens Q9BSJ2
Pull Down
29568061
Intra TUBG1 P23258 TUBGCP5 Homo sapiens Q96RT8
Pull Down
29568061
Intra TUBG1 P23258 TUBGCP3 Homo sapiens Q96CW5
Anti Tag CoIP
26496610
Intra TUBG1 P23258 TUBGCP4 Homo sapiens Q9UGJ1
Anti Tag CoIP
27015882
Intra TUBG1 P23258 TUBGCP2 Homo sapiens Q9BSJ2
Anti Tag CoIP
35271311
Intra TUBG1 P23258 TUBGCP4 Homo sapiens Q9UGJ1
Pull Down
29568061
Intra TUBG1 P23258 TUBGCP5 Homo sapiens Q96RT8
TAP
20360068
Intra TUBG1 P23258 TUBGCP5 Homo sapiens Q96RT8
Anti Tag CoIP
27015882
Intra TUBG1 P23258 TUBGCP4 Homo sapiens Q9UGJ1
Anti Tag CoIP
35271311
Intra TUBG1 P23258 AXIN1 Homo sapiens O15169
Anti Bait CoIP
19390532
Intra TUBG1 P23258 AXIN1 Homo sapiens O15169
IF
19390532
Intra TUBG1 P23258 AXIN1 Homo sapiens O15169
Anti Tag CoIP
19390532
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cortical Dysplasia, Complex, With Other Brain Malformations 4

CDCBM4

Complex Cortical Dysplasia With Other Brain Malformations 4

Dysplasia ,Cortical, Complex, With Other Brain Malformations, Type 4

Chromosome 15q11.2 Deletion Syndrome

15q11.2 Microdeletion Syndrome

15q11.2 Bp1-Bp2 Microdeletion Syndrome

Del(15)(Q11.2)

Monosomy 15q11.2

15q11.2 Microdeletion

Chromosome 15q11.2 Deletion

Chromosome 15q11.2 Microdeletion

Chromosome Deletion Syndrome 15q11.2

Microdeletion 15q11.2

Duplication 15q11-Q13 Syndrome

Lissencephaly

Pachygyria

Broad Gyri Of Cerebrum

Large Gyri Of Cerebrum

Macrogyria

Band Heterotopia

Subcortical Band Heterotopia

Double Cortex Syndrome

Subcortical Laminar Heterotopia

Double Cortex

Band Heterotopia Of Brain

BH

Heco

Heterotopic Cortex

Familial Band Heterotopia

Dc

Dc Syndrome

Heterotopia, Subcortical Band

Sbh

Sclh

Bhy

Tubulinopathy

Tubulinopathies

Microlissencephaly
Immunodeficiency 34

Atypical Mycobacteriosis, Familial, X-Linked 2

X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Cybb Deficiency

IMD34

Amcbx2

Immunodeficiency 34, Mycobacteriosis, X-Linked

X-Linked Msmd Due To Cybb Deficiency

Familial Atypical Mycobacteriosis X-Linked 2

Familial, X-Linked, Atypical Mycobacteriosis 2

Familial Disseminated Atypical Mycobacterial Infection X-Linked 2

Mendelian Susceptibility To Mycobacterial Disease X-Linked 2

X-Linked Immunodeficiency 34, Mycobacteriosis

Immunodeficiency, Type 34, Mycobacteriosis, X-Linked

Lissencephaly 2

Norman-Roberts Syndrome

Lissencephaly Syndrome, Norman-Roberts Type

LIS2

Lissencephaly With Cerebellar Hypoplasia

Lch

Lissencephaly Syndrome Norman-Roberts Type

Norman Roberts Lissencephaly Syndrome

Lissencephaly 3

Lis3

Microlissencephaly Type A

Norman-Roberts Lissencephaly Syndrome

Lissencephaly, Type 2

Cobblestone Lissencephaly

Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly

Congenital Fibrosis Of The Extraocular Muscles

Congenital Fibrosis Of Extraocular Muscles

Cfeom

Feom

Congenital External Ophthalmoplegia

Congenital Fibrosis Syndrome

General Fibrosis Syndrome

Nijmegen Breakage Syndrome

Berlin Breakage Syndrome

NBS

Microcephaly, Normal Intelligence And Immunodeficiency

Ataxia-Telangiectasia Variant

Ataxia-Telangiectasia Variant V1

Seemanova Syndrome Ii

Immunodeficiency-Microcephaly-Chromosomal Instability Syndrome

Seemanova Syndrome Type 2

At-V1

Microcephaly With Normal Intelligence, Immunodeficiency, And Lymphoreticular Malignancies

Nonsyndromal Microcephaly, Autosomal Recessive, With Normal Intelligence

Immunodeficiency, Microcephaly, And Chromosomal Instability

Microcephaly-Immunodeficiency-Lymphoreticuloma Syndrome

Microcephaly Immunodeficiency Lymphoreticuloma

Microcephaly With Normal Intelligence Immunodeficiency And Lymphoreticular Malignancies

Nonsyndromal Microcephaly Autosomal Recessive With Normal Intelligence

Seemanova Syndrome 2

Ataxia-Telangiectasia Variant 1

Seemanova Syndrome

At V1

Ataxia-Telangiectasia, Variant 1

Microcephaly-Immunodeficiency-Lymphoid Malignancy Syndrome

V-At

Ataxia Telangiectasia Variant V1

Polymicrogyria

Pmg

Periventricular Nodular Heterotopia

Periventricular Heterotopia

Pvnh

Familial Nodular Heterotopia

Heterotopia, Periventricular

Periventricular Heterotopia, X-Linked

Miller-Dieker Lissencephaly Syndrome

Miller-Dieker Syndrome

Mds

MDLS

Miller Dieker Syndrome

Classical Lissencephaly Syndrome

Lissencephaly Due To 17p13.3 Deletion

Monosomy 17p13.3

Telomeric Deletion 17p

Classical Lissencephaly

Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia

Primary Microcephaly

True Microcephaly

Microcephaly, Primary

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1

Walker-Warburg Syndrome

Hard Syndrome

Walker-Warburg Congenital Muscular Dystrophy

Cerebroocular Dysplasia-Muscular Dystrophy Syndrome

Cod-Md Syndrome

Chemke Syndrome

Hydrocephalus, Agyria And Retinal Dysplasia

Cerebroocular Dysgenesis

Cerebroocular Dysplasia Muscular Dystrophy Syndrome

Hard +/- E Syndrome

Pagon Syndrome

Warburg Syndrome

Hydrocephalus, Agyria, And Retinal Dysplasia

Mddga

Muscular Dystrophy-Dystroglycanopathy , Type A

Muscular Dystrophy-Dystroglycanopathy [With Brain And Eye Anomalies], Type A

Hydrocephalus-Agyria-Retinal Dysplasia Syndrome

Wws

Dystrophy, Muscular, Dystroglycanopathy, Type A

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus TUBG1 MGD MGI:101834
Bos taurus TUBG1 VGNC VGNC:49987
Felis catus TUBG1 VGNC VGNC:108503
Rattus norvegicus TUBG1 RGD RGD:628606