LGR6 - leucine rich repeat containing G protein-coupled receptor 6 Gene

中文名称：含富含亮氨酸的重复序列的 G 蛋白偶联受体 6

种属: Homo sapiens

同用名: GPCR; VTS20631

基因 ID: 59352 | 基因类型: protein coding

关于 LGR6

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:202,193,799-202,319,761 (from NCBI)

This gene has 8 transcripts (splice variants), 194 orthologues and 22 paralogues. Broad expression in gall bladder (RPKM 3.1), testis (RPKM 2.2) and 22 other tissues.

功能概要

该基因编码 G 蛋白偶联 7 跨膜蛋白超家族中富含亮氨酸重复序列的亚组成员。编码的蛋白质是一种糖蛋白激素受体，具有一个大的 N 末端细胞外结构域，该结构域包含富含亮氨酸的重复序列，对于形成配体结合的马蹄形相互作用基序很重要。该基因的可变剪接导致多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

LGR6 基因产物(3)

mRNA	Protein	Name
NM_001017403.2	NP_001017403.1	leucine-rich repeat-containing G-protein coupled receptor 6 isoform 1 precursor
NM_001017404.2	NP_001017404.1	leucine-rich repeat-containing G-protein coupled receptor 6 isoform 3
NM_021636.3	NP_067649.2	leucine-rich repeat-containing G-protein coupled receptor 6 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	21727895	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of Wnt signaling pathway	IDA IDA: 通过直接分析推断	22615920	GOA
involved in positive regulation of cell migration	IDA IDA: 通过直接分析推断	22615920	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in vesicle	IDA IDA: 通过直接分析推断	22615920	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LGR6 蛋白结构

LRR_1

LRR_8

LRR_1

LRR_8

7tm_1

0
200
400
600
800
967 a.a.

蛋白主名

其他名称

leucine-rich repeat-containing G-protein coupled receptor 6

gonadotropin receptor

LGR6 抗体

目录号	产品名	应用	反应物种
HY-P82786	LGR6 Antibody (YA2531)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Myxedema

Hair Follicle Neoplasm

Hair Matrix Neoplasm

Hair Matrix Tumour

Ankyloglossia With Or Without Tooth Anomalies

Ankyloglossia	ANKG
'Tongue-Tie'	Tongue-Tie
Tongue Tie	Aberrant Insertion Of Labial Frenulum
Aberrant Insertion Of Frenum Of Tongue	Short Frenulum Linguae
Short Frenulum Of Tongue

Ehlers-Danlos Syndrome, Spondylodysplastic Type, 3

Spondylocheirodysplasia, Ehlers-Danlos Syndrome-Like	Scd-Eds
EDSSPD3	Ehlers-Danlos Syndrome Spondylodysplastic Type 3
Ehlers-Danlos Syndrome, Spondylocheirodysplastic Type	Slc39a13-Related Spondylodysplastic Ehlers-Danlos Syndrome
Slc39a13-Related Speds	Slc39a13-Related Spondylodysplastic Eds
Spondylocheirodysplastic Ehlers-Danlos Syndrome	Speds-Slc39a13
Ehlers-Danlos Syndrome-Like Spondylocheirodysplasia	Ehlers-Danlos Syndrome, Spondylodysplastic, Type 3

Pilomatrixoma

Pilomatricoma	PTR
Epithelioma Calcificans Of Malherbe	Benign Pilomatricoma
Calcifying Epithelioma Of Malherbe	Pilomatricoma, Somatic
Benign Pilomatrixoma	Malherbe Calcifying Epithelioma

Premature Ovarian Failure 1

Ovarian Failure, Premature	Fmr1-Related Primary Ovarian Insufficiency
Fragile X-Associated Primary Ovarian Insufficiency	POF1
Pofx	Hypergonadotropic Ovarian Failure, X-Linked
Pof	Primary Ovarian Insufficiency, Fragile X-Associated
Primary Ovarian Insufficiency 1	Ovarian Failure Premature
Premature Ovarian Failure, X-Linked	Fragile X Premature Ovarian Failure
Fmr1-Related Premature Ovarian Failure	Familial Premature Ovarian Failure
Idiopathic Familial Premature Ovarian Failure	Fxpoi
X-Linked Hypergonadotropic Ovarian Failure	Hypergonadotropic Ovarian Failure X-Linked
Poi	Premature Ovarian Failure X-Linked
Primary Ovarian Insufficiency	Premature Ovarian Failure-1
Ovarian Failure, Premature, Type 1	Premature Ovarian Failure, Familial
Premature Menopause	Primary Hypogonadism
Turner Syndrome

Tetraamelia Syndrome

Tetra-Amelia Syndrome	Tetraamelia-Multiple Malformations Syndrome
Tetra-Amelia	Tetra-Amelia, Autosomal Recessive
Tetraamelia, Autosomal Recessive	Total Amelia
Zimmer Phocomelia	Tetams
Zimmer Taub Sova Syndrome

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07620	LGR6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	LGR6	VGNC	VGNC:53617
Mus musculus	LGR6	MGD	MGI:2441805
Rattus norvegicus	LGR6	RGD	RGD:1560339

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