2. Gene
  3. Il21 - interleukin 21 Gene

Il21 - interleukin 21 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: IL-21

基因 ID: 60505 | 基因类型: protein coding

关于 Il21

功能概要

Enables cytokine receptor binding activity. Involved in cellular response to virus; lymphocyte activation involved in immune response; and positive regulation of immunoglobulin production. Acts upstream of or within positive regulation of cytokine production; positive regulation of natural killer cell differentiation; and positive regulation of natural killer cell mediated cytotoxicity. Predicted to be located in extracellular space. Is expressed in ductus deferens; epididymis; and testis. Human ortholog(s) of this gene implicated in asthma; common variable immunodeficiency; hepatocellular carcinoma; and systemic lupus erythematosus. Orthologous to human IL21 (interleukin 21). [provided by Alliance of Genome Resources, Apr 2022]

Il21 基因产物(2)

mRNA Protein Name
NM_001291041.1 NP_001277970.1 interleukin-21 isoform 1 precursor
NM_021782.3 NP_068554.1 interleukin-21 isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cytokine receptor binding IDA
IDA: 通过直接分析推断
11081504 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T follicular helper cell differentiation IMP
IMP: 通过突变表型推断
23045607 MGI
involved in cellular response to virus IMP
IMP: 通过突变表型推断
23045607 MGI
involved in germinal center B cell differentiation IMP
IMP: 通过突变表型推断
23045607 MGI
acts upstream of interleukin-10 production IDA
IDA: 通过直接分析推断
14764669 MGI
acts upstream of natural killer cell cytokine production IDA
IDA: 通过直接分析推断
14764669 MGI
acts upstream of natural killer cell differentiation IDA
IDA: 通过直接分析推断
14764669 MGI
acts upstream of natural killer cell mediated cytotoxicity IDA
IDA: 通过直接分析推断
14764669 MGI
involved in positive regulation of immunoglobulin production IMP
IMP: 通过突变表型推断
23045607 MGI
acts upstream of or within positive regulation of interleukin-10 production IDA
IDA: 通过直接分析推断
14764669 MGI
acts upstream of or within positive regulation of natural killer cell cytokine production IDA
IDA: 通过直接分析推断
14764669 MGI
acts upstream of or within positive regulation of natural killer cell differentiation IDA
IDA: 通过直接分析推断
14764669 MGI
acts upstream of or within positive regulation of natural killer cell mediated cytotoxicity IDA
IDA: 通过直接分析推断
14764669 MGI
acts upstream of or within positive regulation of type II interferon production IDA
IDA: 通过直接分析推断
14764669 MGI
acts upstream of type II interferon production IDA
IDA: 通过直接分析推断
14764669 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

interleukin-21

重组 Il21 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7078 IL-21 Protein, Mouse (129a.a) Q9ES17 (H18-S146) ≥95%
HY-P70643 IL-21 Protein, Mouse (122a.a) Q9ES17 (P25-S146) ≥95%
HY-P78149 IL-21 Protein, Mouse (Biotinylated, His-Avi) Q9ES17 (H18-S146) ≥95%
HY-P700199AF Animal-Free IL-21 Protein, Mouse (His) Q9ES17 (H18-S146) ≥95%
HY-P700294 IL-21 Protein, Mouse (His) Q9ES17 (P25-S146) ≥95%

相关产品

Clinical Phase
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P99451 Avizakimab Inhibitor 99.35% Phase 2
HY-P99687 Latikafusp Inhibitor 99.00% Phase 1
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-162490 TF-S14 Inhibitor / 否
HY-RS06734 IL21 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06735 IL21R Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Il21 NCBI NCBI:59067
Canis familiaris Il21 NCBI NCBI:442935
Macaca fascicularis Il21 NCBI NCBI:102130762
Rattus norvegicus Il21 NCBI NCBI:365769
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