2. Gene
  3. CEACAM1 - CEA cell adhesion molecule 1 Gene

CEACAM1 - CEA cell adhesion molecule 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CEA 细胞粘附分子 1

种属: Homo sapiens

同用名: BGP; BGP1; BGPI

基因 ID: 634 | 基因类型: protein coding

关于 CEACAM1

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:42,507,306-42,528,481 (from NCBI)

This gene has 15 transcripts (splice variants), 570 orthologues and 24 paralogues. Biased expression in colon (RPKM 99.7), esophagus (RPKM 21.9) and 12 other tissues.

功能概要

该基因编码属于免疫球蛋白超家族的癌胚抗原 (CEA) 基因家族的成员。 CEA 家族的两个亚群，CEA 细胞粘附分子和妊娠特异性糖蛋白，位于 19 号染色体长臂上一个 1.2 Mb 的簇内。CEA 细胞粘附分子亚群的 11 个假基因也在该簇中被发现。编码的蛋白质最初在肝脏胆管中被描述为胆汁糖蛋白。随后，发现它是一种在白细胞、上皮细胞和内皮细胞上检测到的细胞间粘附分子。编码的蛋白质通过与该亚组其他蛋白质的嗜同性和异嗜性结合介导细胞粘附。多种细胞活动归因于编码的蛋白质，包括在组织三维结构的分化和排列、血管生成、细胞凋亡、肿瘤抑制、转移以及先天和适应性免疫反应的调节中的作用。已经报道了编码不同亚型的多个转录变体，但尚未定义所有变体的全长性质。[RefSeq 提供，2010 年 5 月]

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, Apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]

CEACAM1 基因产物(6)

mRNA Protein Name
NM_001024912.3 NP_001020083.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 2 precursor
NM_001184813.2 NP_001171742.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 4 precursor
NM_001184815.2 NP_001171744.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 3 precursor
NM_001184816.2 NP_001171745.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 5 precursor
NM_001205344.2 NP_001192273.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 6 precursor
NM_001712.5 NP_001703.2 carcinoembryonic antigen-related cell adhesion molecule 1 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables actin binding IPI
IPI: 通过物理相互作用推断
17192268 GOA
enables filamin binding IPI
IPI: 通过物理相互作用推断
16291724 GOA
enables identical protein binding IDA
IDA: 通过直接分析推断
26483485 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
19948502 GOA
enables kinase binding IPI
IPI: 通过物理相互作用推断
7478590 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11035932 GOA
enables protein phosphatase binding IPI
IPI: 通过物理相互作用推断
18424730 GOA
enables protein tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
18424730 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of T cell mediated cytotoxicity IDA
IDA: 通过直接分析推断
18424730 GOA
involved in negative regulation of T cell receptor signaling pathway IDA
IDA: 通过直接分析推断
18424730 GOA
involved in negative regulation of cytotoxic T cell degranulation IDA
IDA: 通过直接分析推断
18424730 GOA
involved in negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP
IMP: 通过突变表型推断
23696226 GOA
involved in regulation of cell migration IDA
IDA: 通过直接分析推断
16291724 GOA
involved in wound healing, spreading of cells IDA
IDA: 通过直接分析推断
16291724 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of T cell receptor complex IDA
IDA: 通过直接分析推断
18424730 GOA
located in apical plasma membrane IDA
IDA: 通过直接分析推断
10436421 GOA
located in cell junction IDA
IDA: 通过直接分析推断
8018919 GOA
located in cell surface IDA
IDA: 通过直接分析推断
25363763 GOA
located in cell-cell junction IDA
IDA: 通过直接分析推断
16291724 GOA
located in membrane IDA
IDA: 通过直接分析推断
11994468 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
17192268 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CEACAM1 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (35 - 140)

Ig_3

Ig_3: Immunoglobulin domain (146 - 219)

Ig_2

Ig_2: Immunoglobulin domain (240 - 314)

ig

ig: Immunoglobulin domain (342 - 398)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 526 a.a.
蛋白主名 其他名称

carcinoembryonic antigen-related cell adhesion molecule 1

CD66a antigen

重组 CEACAM1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72128 CEACAM1 Protein, Human (His-SUMO) P13688-1 (Q35-G428) ≥95%
HY-P72129 CEACAM1 Protein, Human P13688-1 (Q35-G428) ≥95%
HY-P72695 CEACAM1 Protein, Human (HEK293, His) P13688-1 (Q35-G428) ≥95%
HY-P72932 CEACAM1 Protein, Human (HEK293, His-Fc) P13688-1 (Q35-G428) ≥95%
HY-P78894 CEACAM1 Protein, Human (Biotinylated, HEK293, His-Avi) P13688-1 (Q35-G428) ≥95%
HY-P72129A CEACAM1 Protein, Human (N-His) P13688-1 (Q35-G428) ≥95%

关联疾病

疾病名称 别名
Acute Gonococcal Endometritis

Gonococcal Endometritis

Acute Gonorrhea Of Uterus

Uterus - Acute Gonorrhoea
Adenomatoid Tumor

Adenomatoid Tumour

Benign Localised Epithelial Mesothelioma

Benign Localized Epithelial Mesothelioma
Acute Cervicitis
Acute Gonococcal Cervicitis

Gonococcal Cervicitis

Acute Gonorrhea Of Cervix
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Gastrointestinal Carcinoma

Gastrointestinal Neoplasms
Chronic Gonococcal Salpingitis

Gonococcal Salpingitis
Fallopian Tube Disease

Fallopian Tube Diseases
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Salpingitis
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-163028 ML-T7 99.93% 否
HY-155175 TIM-3-IN-2 Inhibitor 99.36% 否
HY-159884 MG-T-19 / 否
HY-RS02435 CEACAM1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CEACAM1 RGD RGD:67396
Canis familiaris CEACAM1 NCBI NCBI:612435
Mus musculus CEACAM1 NCBI NCBI:26365
Others CEACAM1 NCBI
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