CCL18 - C-C motif chemokine ligand 18 Gene

中文名称：CC 基序趋化因子配体 18

种属: Homo sapiens

同用名: CKb7; PARC; AMAC1; DCCK1; MIP-4; AMAC-1; DC-CK1; SCYA18

基因 ID: 6362 | 基因类型: protein coding

关于 CCL18

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:36,064,272-36,072,032 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 173 orthologues and 25 paralogues. Biased expression in lung (RPKM 88.7), lymph node (RPKM 45.6) and 9 other tissues.

功能概要

这种抗菌基因是聚集在 17 号染色体 q 臂上的几个 Cys-Cys (CC) 细胞因子基因之一。细胞因子是一个参与免疫调节和炎症过程的分泌蛋白家族。 CC 细胞因子是以两个相邻的半胱氨酸为特征的蛋白质。由该基因编码的细胞因子对幼稚 T 细胞、CD4+ 和 CD8+ T 细胞以及非活化淋巴细胞显示出趋化活性，但对单核细胞或粒细胞没有趋化活性。这种趋化因子将幼稚 T 淋巴细胞吸引到树突状细胞并激活淋巴结中的巨噬细胞。它可能在体液和细胞介导的免疫反应中发挥作用。[RefSeq 提供，2014 年 9 月]

This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014]

CCL18 基因产物(1)

mRNA	Protein	Name
NM_002988.4	NP_002979.1	C-C motif chemokine 18 precursor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	21481794	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: 通过直接分析推断	12949249	GOA
involved in killing of cells of another organism	IDA IDA: 通过直接分析推断	12949249	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CCL18 蛋白结构

IL8

0
89 a.a.

蛋白主名

其他名称

C-C motif chemokine 18

CC chemokine PARC

CCL18 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CCL18	P55774	PITPNM3	Homo sapiens	Q9BZ71	Confocal	21481794
种属内	CCL18	P55774	PITPNM3	Homo sapiens	Q9BZ71	Competition Binding	21481794

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CCL18 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7265	MIP-4/CCL18 Protein, Human	P55774 (A21-A89)	≥95%
HY-P72759	MIP-4/CCL18 Protein, Human (His)	P55774 (A21-A89)	≥95%
HY-P700545	MIP-4/CCL18 Protein, Human (P. pastoris, His)	P55774 (A21-A89)	≥95%

关联疾病

疾病名称

别名

Septic Arthritis

Infectious Arthritis	Arthritis, Infectious
Arthritis Septic	Arthritis, Bacterial

Gaucher'S Disease

Gaucher Disease	Kerasin Thesaurismosis
Glucocerebrosidase Deficiency	Glucosylceramidase Deficiency
Cerebroside Lipidosis Syndrome	Acid Beta-Glucosidase Deficiency
Glucosylceramide Beta-Glucosidase Deficiency	Acute Cerebral Gaucher Disease
Gaucher Splenomegaly	Glucocerebrosidosis
Glucosyl Cerebroside Lipidosis	Kerasin Lipoidosis
Lipoid Histiocytosis	Glocucerebrosidase Deficiency
Sphingolipidosis 1	Gaucher Syndrome
Gauchers Disease	Gd
Glucosylceramide Lipidosis	Kerasin Histiocytosis
Gaucher Disease, Type 1	Gaucher Disease, Type 2

Pulmonary Fibrosis

Fibrosis Of Lung

Niemann-Pick Disease

Sphingomyelin/Cholesterol Lipidosis	Niemann-Pick Diseases
Lipoid Histiocytosis	Sphingomyelin Lipidosis
Sphingomyelinase Deficiency Disease	Lipid Histiocytosis
Neuronal Cholesterol Lipidosis	Neuronal Lipidosis
Npd	Sphingomyelinase Deficiency
Niemann-Pick Disease, Type A

Dermatitis

Eczema	Skin Inflammation
Inflammatory Dermatosis

Mansonelliasis

Mansonellosis	Mansonella Perstans Infections
Mansonella Infestation

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Sarcoidosis 1

Sarcoidosis	Boeck Sarcoid
Besnier-Boeck-Schaumann Disease	SS1
Sarcoidosis, Susceptibility To, 1	Lymphogranulomatosis
Hodgkin Disease	Boeck'S Disease
Boeck'S Sarcoid	Schaumann'S Disease Or Syndrome
Hutchinson-Boeck Disease Or Syndrome

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Nonspecific Interstitial Pneumonia

Nsip	Non-Specific Interstitial Pneumonia
Non-Specific Idiopathic Interstitial Pneumonia	Non-Specific Interstitial Pneumonia Nos

Systemic Scleroderma

Scleroderma	Progressive Systemic Sclerosis
Systemic Sclerosis	Scleroderma, Systemic
Scleroderma Syndrome	Dermatosclerosis
Familial Progressive Scleroderma	Progressive Scleroderma
Scleroderma Disease	Scleroderma, Localized
Diffuse Scleroderma	Scleroderma, Familial Progressive

Idiopathic Interstitial Pneumonia

Hamman-Rich Syndrome	Diffuse Idiopathic Pulmonary Fibrosis
Idiopathic Fibrosing Alveolitis	Ipf
Idiopathic Interstitial Pneumonias	Idiopathic Interstitial Pneumonia, Not Otherwise Specified
Pulmonary Fibrosis

Gaucher Disease, Type I

Glucocerebrosidase Deficiency	Acid Beta-Glucosidase Deficiency
Gba Deficiency	GD1
Gd I	Gaucher Disease, Noncerebral Juvenile
Gaucher Disease Type 1	Gaucher Disease Type I
Gaucher'S Disease Type I	Gaucher Disease
Gd 1	Non-Cerebral Juvenile Gaucher Disease
GD	Gaucher Disease 1
Adult Non-Neuronopathic Gaucher Disease	Noncerebral Juvenile Gaucher Disease
Type 1 Gaucher Disease	Gaucher Disease, Type 1

Breast Malignant Phyllodes Tumor

Malignant Cystosarcoma Phyllodes	Malignant Phyllodes Tumor Of Breast
Malignant Phyllodes Tumour Of Breast	Phyllodes Breast Tumor
Phyllodes Tumor Of The Breast	Breast Malignant Phyllodes Tumour
Malignant Mammary Phyllodes Tumor	Malignant Mammary Phyllodes Tumour
Malignant Phyllodes Neoplasm	Malignant Phyllodes Tumor
Malignant Phyllodes Tumour	Phyllodes Breast Neoplasm
Phyllodes Breast Tumour	Phyllodes Tumor, Malignant
Cystosarcoma Phyllodes	Cystosarcoma Phyllodes Of The Breast
Phylloides Tumor	Malignant Breast Phyllodes Tumor
Breast Phyllodes Tumor	Phyllodes Tumor
Malignant Phyllodes Cystosarcoma Of Unspecified Site

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Gaucher Disease, Type Iii

Gaucher Disease, Subacute Neuronopathic Type	Gd Iii
Gaucher Disease, Chronic Neuronopathic Type	Gaucher Disease, Juvenile And Adult, Cerebral
Gaucher Disease Type 3	GD3
Gaucher'S Disease Type Iii	Gaucher Disease Type Iii
Gd 3	Cerebral Juvenile And Adult Form Of Gaucher Disease
Chronic Neuronopathic Gaucher Disease	Gaucher Disease 3
Cerebral, Juvenile And Adult, Gaucher Disease	Gaucher Disease Chronic Neuronopathic Type
Gaucher Disease Type Ii	Subacute Neuronopathic Gaucher Disease
Type 3 Gaucher Disease	Gaucher Disease, Type 3
Gaucher Disease, Type 2

Sphingolipidosis

Sphingolipidoses

Cerebral Palsy

Infantile Cerebral Palsy	Mixed Cerebral Palsy
Palsy Cerebral	Palsy, Cerebral
Cerebral Palsy, Mixed

Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis	Ipf
Fibrocystic Pulmonary Dysplasia	Pulmonary Fibrosis, Idiopathic
Pulmonary Fibrosis, Idiopathic, Susceptibility To	Cryptogenic Fibrosing Alveolitis
ILD2	Idiopathic Pulmonary Fibrosis, Familial
Fibrosing Alveolitis, Cryptogenic	Uip
Fibrosing Alveolitis	Interstitial Pneumonitis, Usual
Familial Idiopathic Pulmonary Fibrosis	Idiopathic Fibrosing Alveolitis, Chronic Form
Usual Interstitial Pneumonia	Fibrosing Alveolitis Cryptogenic
Hamman-Rich Disease	Idiopathic Pulmonary Fibrosis Familial
Interstitial Pneumonitis Usual	Fibrosis Idiopathic Pulmonary
Fibrosis, Pulmonary, Idiopathic	Hamman-Rich Syndrome
Chronic Idiopathic Pulmonary Fibrosis	Acute Interstitial Pneumonia
Interstitial Pulmonary Fibrosis	Ipf - [Idiopathic Pulmonary Fibrosis]
Idiopathic Lung Fibrosis	Fibrosing Lung Disease
Pulmonary Fibrosis Nos	Fibrosing Pneumonitis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02087	CCL18 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	CCL18	VGNC	VGNC:99132
Mus musculus	CCL18	MGD	MGI:98260
Others	CCL18	NCBI

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