1. Gene
  2. Slc5a2 - solute carrier family 5 member 2 Gene

Slc5a2 - solute carrier family 5 member 2 Gene

中文名称:溶质载体家族 5 成员 2

种属: Rattus norvegicus

同用名: Sglt2

基因 ID: 64522 | 基因类型: protein coding

关于 Slc5a2

Primary_assembly 1: 182,847,106-182,853,306 forward strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 200 orthologues, 13 paralogues and is associated with 4 phenotypes. Biased expression in Kidney (RPKM 171.3) and Lung (RPKM 4.8).

功能概要

该基因编码的蛋白可启动葡萄糖:钠同向转运体活性。参与葡萄糖跨膜转运;尿量的负调节;和肾钾排泄。位于刷状缘膜。是膜的组成部分。用于研究高血压。该基因的人类直系同源物与肾糖尿有关。与人类 SLC5A2(溶质载体家族 5 成员 2)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables glucose:sodium symporter activity. Involved in glucose transmembrane transport; negative regulation of urine volume; and renal potassium excretion. Located in brush border membrane. Is integral component of membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in renal glycosuria. Orthologous to human SLC5A2 (solute carrier family 5 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc5a2 基因产物(1)

mRNA Protein Name
NM_022590.2 NP_072112.2 sodium/glucose cotransporter 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables D-glucose:sodium symporter activity IDA
IDA: 通过直接分析推断
7493971 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in D-glucose transmembrane transport IDA
IDA: 通过直接分析推断
7493971 RGD
involved in negative regulation of urine volume IMP
IMP: 通过突变表型推断
29790389 RGD
involved in renal potassium excretion IMP
IMP: 通过突变表型推断
29790389 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in brush border membrane IDA
IDA: 通过直接分析推断
14506074 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Slc5a2 蛋白结构

SLC5-6-like_sbd

SLC5-6-like_sbd: cl00456 (21 - 669)

  • 0
  • 200
  • 400
  • 600
  • 670 a.a.
蛋白主名 其他名称

sodium/glucose cotransporter 2

Na(+)/glucose cotransporter 2

low affinity Na-dependent glucose transporter (SGLT2)

low affinity sodium-glucose cotransporter

solute carrier family 5 (sodium/glucose cotransporter), member 2

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Slc5a2 NCBI NCBI:6524