ALDH8A1 - aldehyde dehydrogenase 8 family member A1 Gene

中文名称：醛脱氢酶 8 家族成员 A1

种属: Homo sapiens

同用名: ALDH12; DJ352A20.2

关于 ALDH8A1

功能概要

该基因编码醛脱氢酶蛋白质家族的成员。编码的蛋白质与 9-顺式-视黄酸的合成和氨基酸色氨酸的分解有关。这种酶将 9-cis-retinal 转化为类视黄醇 X 受体配体 9-cis-retinoic acid，并且对 9-cis-retinal 的活性比对全反式视黄醛的活性高约 40 倍。此外，该酶已被证明可在色氨酸分解代谢的犬尿氨酸途径中催化 2-氨基粘康酸半醛转化为 2-氨基粘康酸。[RefSeq 提供，2018 年 7 月]

This gene encodes a member of the aldehyde dehydrogenase family of proteins. The encoded protein has been implicated in the synthesis of 9-cis-retinoic acid and in the breakdown of the amino acid tryptophan. This Enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. In addition, this Enzyme has been shown to catalyze the conversion of 2-aminomuconic semialdehyde to 2-aminomuconate in the kynurenine pathway of tryptophan catabolism. [provided by RefSeq, Jul 2018]