1. Gene
  2. BNIP1 - BCL2 interacting protein 1 Gene

BNIP1 - BCL2 interacting protein 1 Gene

中文名称:BCL2 相互作用蛋白 1

种属: Homo sapiens

同用名: NIP1; SEC20; TRG-8

基因 ID: 662 | 基因类型: protein coding

关于 BNIP1

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:173,144,531-173,164,387 (from NCBI)

This gene has 5 transcripts (splice variants) and 276 orthologues. Ubiquitous expression in bone marrow (RPKM 8.6), testis (RPKM 6.9) and 25 other tissues.

功能概要

该基因是 BCL2/腺病毒 E1B 19 kd 相互作用蛋白 (BNIP) 家族的成员。它与 E1B 19 kDa 蛋白相互作用,保护细胞免受病毒诱导的细胞死亡。编码的蛋白质还与 BCL2 的 E1B 19 kDa 样序列相互作用,BCL2 是另一种凋亡保护因子。此外,该蛋白质还参与囊泡向内质网的运输。该基因的可变剪接导致四种具有相同 N 和 C 末端的蛋白质产物。[RefSeq 提供,2011 年 3 月]

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. In addition, this protein is involved in vesicle transport into the endoplasmic reticulum. Alternative splicing of this gene results in four protein products with identical N- and C-termini. [provided by RefSeq, Mar 2011]

BNIP1 基因产物(4)

mRNA Protein Name
NM_001205.3 NP_001196.2 vesicle transport protein SEC20 isoform BNIP1
NM_013978.3 NP_053581.2 vesicle transport protein SEC20 isoform BNIP1-a
NM_013979.3 NP_053582.2 vesicle transport protein SEC20 isoform BNIP1-b
NM_013980.3 NP_053583.2 vesicle transport protein SEC20 isoform BNIP1-c
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SNAP receptor activity IDA
IDA: 通过直接分析推断
15272311 GOA
enables calcium-induced calcium release activity IDA
IDA: 通过直接分析推断
29222049 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
7954800 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within apoptotic process IPI
IPI: 通过物理相互作用推断
7954800 GOA
involved in apoptotic process in response to mitochondrial fragmentation IDA
IDA: 通过直接分析推断
29222049 GOA
involved in endoplasmic reticulum membrane fusion IMP
IMP: 通过突变表型推断
15272311 GOA
involved in endoplasmic reticulum organization IMP
IMP: 通过突变表型推断
15272311 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SNARE complex IDA
IDA: 通过直接分析推断
15272311 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
7954800 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
15272311 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
23896122 GOA
located in intracellular membrane-bounded organelle IDA
IDA: 通过直接分析推断
7954800 GOA
located in mitochondrial membrane IDA
IDA: 通过直接分析推断
21931693 GOA
is active in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
23896122 GOA
located in nuclear envelope IDA
IDA: 通过直接分析推断
7954800 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

BNIP1 蛋白结构

Sec20

Sec20: Sec20 (134 - 224)

  • 0
  • 100
  • 200
  • 228 a.a.
蛋白主名 其他名称

vesicle transport protein SEC20

BCL2/adenovirus E1B 19 kDa protein-interacting protein 1

BNIP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
BNIP1 Q12981 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
种属内
BNIP1 Q12981 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
种属内
BNIP1 Q12981 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
种属内
BNIP1 Q12981 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
种属内
BNIP1 Q12981 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
32296183
种属内
BNIP1 Q12981 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
种属内
BNIP1 Q12981 HSD17B11 Homo sapiens Q8NBQ5
Y2H Prey Pooling
32296183
种属内
BNIP1 Q12981 HSD17B11 Homo sapiens Q8NBQ5
Y2H Array
32296183
种属内
BNIP1 Q12981 HSD17B11 Homo sapiens Q8NBQ5
Validated Y2H
32296183
种属内
BNIP1 Q12981 VMA21 Homo sapiens Q3ZAQ7
Y2H Array
32296183
种属内
BNIP1 Q12981 VMA21 Homo sapiens Q3ZAQ7
Validated Y2H
32296183
种属内
BNIP1 Q12981 VMA21 Homo sapiens Q3ZAQ7
Y2H Prey Pooling
32296183
种属内
BNIP1 Q12981 STOM Homo sapiens P27105
Y2H Array
32296183
种属内
BNIP1 Q12981 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
种属内
BNIP1 Q12981 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
种属内
BNIP1 Q12981 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
种属内
BNIP1 Q12981 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
种属内
BNIP1 Q12981 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
种属内
BNIP1 Q12981 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
种属内
BNIP1 Q12981 ELOVL4 Homo sapiens Q9GZR5
Validated Y2H
32296183
种属内
BNIP1 Q12981 FAM174A Homo sapiens Q8TBP5
Y2H Prey Pooling
32296183
种属内
BNIP1 Q12981 FAM174A Homo sapiens Q8TBP5
Validated Y2H
32296183
种属内
BNIP1 Q12981 FAM174A Homo sapiens Q8TBP5
Y2H Array
32296183
种属内
BNIP1 Q12981 MARCHF5 Homo sapiens Q9NX47
Validated Y2H
32296183
种属内
BNIP1 Q12981 SLC7A14 Homo sapiens Q8TBB6
Validated Y2H
32296183
种属内
BNIP1 Q12981 SLC7A14 Homo sapiens Q8TBB6
Y2H Prey Pooling
32296183
种属内
BNIP1 Q12981 SLC7A14 Homo sapiens Q8TBB6
Y2H Array
32296183
种属内
BNIP1 Q12981 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
种属内
BNIP1 Q12981 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
种属内
BNIP1 Q12981 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
种属内
BNIP1 Q12981 TM4SF19 Homo sapiens Q96DZ7
Y2H Array
32296183
种属内
BNIP1 Q12981 TM4SF19 Homo sapiens Q96DZ7
Y2H Prey Pooling
32296183
种属内
BNIP1 Q12981 TM4SF19 Homo sapiens Q96DZ7
Validated Y2H
32296183
种属内
BNIP1 Q12981 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
种属内
BNIP1 Q12981 STX1A Homo sapiens Q16623
Validated Y2H
32296183
种属内
BNIP1 Q12981 STX1A Homo sapiens Q16623
Y2H Array
32296183
种属内
BNIP1 Q12981 CYB561 Homo sapiens P49447
Y2H Array
32296183
种属内
BNIP1 Q12981 CYB561 Homo sapiens P49447
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

BNIP1 抗体

目录号 产品名 应用 反应物种
HY-P83584 BNIP1 Antibody (YA3329) WB, IHC-P Human, Mouse, Rat

关联疾病

疾病名称 别名
Pyloric Stenosis
Smith-Mccort Dysplasia 1

Smith-Mccort Dysplasia

SMC1

Smc

Smith Mccort Dysplasia

Smith-Mccort Dwarfism

Dyggve-Melchior-Clausen Disease

Dyggve-Melchior-Clausen Syndrome

DMC

Dmc Disease

Pseudo-Morquio Disease Type I

Dmc Syndrome

Fumarase Deficiency

Fumaric Aciduria

FMRD

Fumarate Hydratase Deficiency

Deficiency, Fumarase

Peroxisome Biogenesis Disorder 1b

Peroxisome Biogenesis Disorder

Infantile Refsum Disease

Infantile Phytanic Acid Storage Disease

PBD1B

Refsum Disease, Infantile

Adrenoleukodystrophy, Autosomal Neonatal

Ird

Mild Pbd-Zsd

Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Pbd-Zsd

Peroxisome Biogenesis Disorder Spectrum

Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Autosomal Neonatal Adrenoleukodystrophy

Refsum Disease Infantile

Peroxisome Biogenesis Disorders

Peroxisome Biogenesis Disorder, Type 1b

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus BNIP1 MGD MGI:109328
Canis familiaris BNIP1 VGNC VGNC:38492
Macaca mulatta BNIP1 VGNC VGNC:70271
Rattus norvegicus BNIP1 RGD RGD:620799
Felis catus BNIP1 VGNC VGNC:60143
Bos taurus BNIP1 VGNC VGNC:26531