1. Gene
  2. SSTR4 - somatostatin receptor 4 Gene

SSTR4 - somatostatin receptor 4 Gene

中文名称:生长抑素受体 4

种属: Homo sapiens

同用名: SS4R; SST4; SS4-R; SS-4-R

基因 ID: 6754 | 基因类型: protein coding

关于 SSTR4

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:23,035,312-23,039,237 (from NCBI)

This gene has 1 transcript (splice variant), 100 orthologues and 17 paralogues.

功能概要

生长抑素作用于许多位点以抑制许多激素和其他分泌蛋白的释放。生长抑素的生物学作用可能是由以组织特异性方式表达的 G 蛋白偶联受体家族介导的。 SSTR4 是具有七个跨膜区段的受体超家族的成员,并且在胎儿和成人脑和肺中以最高水平表达。[RefSeq 提供,2008 年 7 月]

Somatostatin acts at many sites to inhibit the release of many Hormones and Other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008]

SSTR4 基因产物(1)

mRNA Protein Name
NM_001052.4 NP_001043.2 somatostatin receptor type 4
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19426801 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SSTR4 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (64 - 311)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
蛋白主名 其他名称

somatostatin receptor type 4

G-protein coupled receptor

SSTR4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SSTR4 P31391 SSTR5 Homo sapiens P35346
Anti Tag CoIP
19426801
种属内
SSTR4 P31391 SSTR5 Homo sapiens P35346
IF
19426801
种属内
SSTR4 P31391 SSTR5 Homo sapiens P35346
FRET
19426801
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hormone Producing Pituitary Cancer

Growth Hormone Producing Pituitary Tumor

Pituitary Tumors, Hormone Producing

Somatotropinoma

Growth Hormone-Producing Pituitary Gland Neoplasm

Prolactinoma

Prolactin-Producing Pituitary Gland Adenoma

Prolactin-Secreting Pituitary Adenoma

Forbes-Albright Syndrome

Lactotroph Adenoma

Prl-Secreting Pituitary Adenoma

Prloma

Pituitary Lactotrophic Adenoma

Familial Prolactinoma

Pituitary Adenoma, Prolactin-Secreting

Prolactinoma Of Pituitary Gland

PSPA

Hyperpituitarism
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Functioning Pituitary Adenoma

Secretory Adenoma Of The Pituitary Gland

Endocrine Active Pituitary Adenoma

Secreting Pituitary Adenoma

Pituitary Adenoma, Functioning

Sotos Syndrome

Cerebral Gigantism

SOTOS

Chromosome 5q35 Deletion Syndrome

Sotos Syndrome 1, Formerly

Sotos1, Formerly

Distinctive Facial Appearance, Overgrowth In Childhood, And Learning Disabilities Or Delayed Development

Sotos Sequence

Sotos' Syndrome

Sotos1

Sotos Syndrome 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus SSTR4 MGD MGI:105372
Rattus norvegicus SSTR4 RGD RGD:3764
Felis catus SSTR4 VGNC VGNC:65713
Macaca mulatta SSTR4 VGNC VGNC:77895