2. Gene
  3. Sirt5 - sirtuin 5 Gene

Sirt5 - sirtuin 5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：沉默信息调节因子 2 相关酶类 5

种属: Mus musculus

同用名: 0610012J09Rik; 1500032M05Rik

基因 ID: 68346 | 基因类型: protein coding

关于 Sirt5

Chromosome 13: 43,518,972-43,548,679 forward strand.GRCm39:CM001006.3

This gene has 11 transcripts (splice variants), 265 orthologues, 6 paralogues and is associated with 2 phenotypes. Ubiquitous expression in heart adult (RPKM 3.8), bladder adult (RPKM 2.9) and 28 other tissues.

功能概要

该基因编码的蛋白可启动蛋白质-glutaryllysine deglutarylase 活动；蛋白质-丙二酰赖氨酸脱丙二酰酶活性；和蛋白质-琥珀酰赖氨酸脱琥珀酰酶活性。参与蛋白质脱酰和调节酮类生物合成过程。在琥珀酸脱氢酶活性和缺血反应的调节上游或调节内起作用。位于胞质溶胶和线粒体内膜。以多种结构表达，包括第 1 鳃弓上颌骨成分；心;卵母细胞;腭架;和感觉器官。与人类 SIRT5（sirtuin 5）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein-glutaryllysine deglutarylase activity; protein-malonyllysine demalonylase activity; and protein-succinyllysine desuccinylase activity. Involved in protein deacylation and regulation of ketone biosynthetic process. Acts upstream of or within regulation of Succinate Dehydrogenase activity and response to ischemia. Located in cytosol and mitochondrial inner membrane. Is expressed in several structures, including 1st branchial arch maxillary component; heart; oocyte; palatal shelf; and sensory organ. Orthologous to human SIRT5 (Sirtuin 5). [provided by Alliance of Genome Resources, Apr 2022]

Sirt5 基因产物(1)

mRNA Protein Name
NM_178848.3 NP_849179.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19410549 MGI
enables protein-glutaryllysine deglutarylase activity IDA
IDA: 通过直接分析推断
24703693 MGI
enables protein-malonyllysine demalonylase activity IDA
IDA: 通过直接分析推断
24703693 MGI
enables protein-malonyllysine demalonylase activity IMP
IMP: 通过突变表型推断
21908771 MGI
enables protein-succinyllysine desuccinylase activity IDA
IDA: 通过直接分析推断
24703693 MGI
enables protein-succinyllysine desuccinylase activity IMP
IMP: 通过突变表型推断
21908771 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in peptidyl-lysine demalonylation IMP
IMP: 通过突变表型推断
21908771 MGI
acts upstream of or within peptidyl-lysine desuccinylation IMP
IMP: 通过突变表型推断
26388266 MGI
involved in peptidyl-lysine desuccinylation IMP
IMP: 通过突变表型推断
21908771 MGI
involved in protein deglutarylation IDA
IDA: 通过直接分析推断
24703693 MGI
involved in protein demalonylation IDA
IDA: 通过直接分析推断
24703693 MGI
involved in protein desuccinylation IDA
IDA: 通过直接分析推断
24703693 MGI
involved in protein desuccinylation IMP
IMP: 通过突变表型推断
23806337 MGI
involved in regulation of ketone biosynthetic process IMP
IMP: 通过突变表型推断
24315375 MGI
acts upstream of or within regulation of succinate dehydrogenase activity IMP
IMP: 通过突变表型推断
26388266 MGI
acts upstream of or within response to ischemia IMP
IMP: 通过突变表型推断
26388266 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
23806337 MGI
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
18054327 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
17923681 MGI
is active in mitochondrion IMP
IMP: 通过突变表型推断
26388266 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Sirt5 蛋白结构

SIRT5_Af1_CobB

SIRT5_Af1_CobB: cd01412 (50 - 300)

  • 0
  • 100
  • 200
  • 310 a.a.
蛋白主名 其他名称

NAD-dependent protein deacylase sirtuin-5, mitochondrial

NAD-dependent deacetylase sirtuin-5

NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0879A Suramin sodium salt Inhibitor 99.48% 是
HY-B0879 Suramin Inhibitor / 否
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-146387 SIRT5 inhibitor 3 Inhibitor ≥98.0% 否
HY-145651 Et-29 Inhibitor 99.89% 否
HY-152214 SIRT5 inhibitor 5 Inhibitor / 否
HY-146386 SIRT5 inhibitor 2 Inhibitor / 否
HY-150727 SIRT5 inhibitor 4 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sirt5 NCBI NCBI:23408
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