2. Gene
  3. Ddr2 - discoidin domain receptor tyrosine kinase 2 Gene

Ddr2 - discoidin domain receptor tyrosine kinase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：盘基蛋白结构域 受体酪氨酸激酶 2

种属: Rattus norvegicus

同用名: Tyro10

基因 ID: 685781 | 基因类型: protein coding

关于 Ddr2

Primary_assembly 13: 82,195,463-82,317,363 reverse strand.mRatBN7.2:CM026986.1

This gene has 2 transcripts (splice variants), 263 orthologues, 54 paralogues and is associated with 32 phenotypes. Biased expression in Uterus (RPKM 164.7), Heart (RPKM 14.2) and 8 other tissues.

功能概要

该基因编码的蛋白可启动胶原蛋白结合活性。参与多个过程，包括细胞死亡的负调节；细胞群增殖的正向调节；胶原生物合成过程的正向调控。位于顶端质膜。用于研究酒精性肝硬化。酒精性肝硬化的生物标志物。该基因的人类直系同源物与胃肠道系统癌症有关（多个）；骨关节炎;和脊椎骨骨骺发育不良，短肢手型。与人类 DDR2（盘状蛋白结构域受体酪氨酸激酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables collagen binding activity. Involved in several processes, including negative regulation of cell death; positive regulation of cell population proliferation; and positive regulation of collagen biosynthetic process. Located in apical plasma membrane. Used to study alcoholic liver cirrhosis. Biomarker of alcoholic liver cirrhosis. Human ortholog(s) of this gene implicated in gastrointestinal system Cancer (multiple); osteoarthritis; and spondylometaepiphyseal dysplasia, short limb-hand type. Orthologous to human DDR2 (Discoidin Domain Receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ddr2 基因产物(1)

mRNA Protein Name
NM_031764.3 NP_113952.2 discoidin domain-containing receptor 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables collagen binding IDA
IDA: 通过直接分析推断
12220173 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to angiotensin IEP
IEP: 通过表达模式推断
26674152 RGD
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
18664364 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: 通过表达模式推断
16087782 RGD
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
23409069 RGD
involved in negative regulation of hydrogen peroxide-mediated programmed cell death IMP
IMP: 通过突变表型推断
32412792 RGD
involved in negative regulation of kinase activity IMP
IMP: 通过突变表型推断
19762078 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
26674152 RGD
involved in positive regulation of G1/S transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
32412792 RGD
involved in positive regulation of collagen biosynthetic process IDA
IDA: 通过直接分析推断
24938620 RGD
involved in positive regulation of collagen biosynthetic process IMP
IMP: 通过突变表型推断
26674152 RGD
involved in positive regulation of hepatic stellate cell activation IMP
IMP: 通过突变表型推断
23409069 RGD
involved in positive regulation of hepatic stellate cell proliferation IMP
IMP: 通过突变表型推断
23409069 RGD
involved in positive regulation of vascular associated smooth muscle cell migration IMP
IMP: 通过突变表型推断
18664364 RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
16087782 RGD
involved in positive regulation of wound healing IMP
IMP: 通过突变表型推断
26674152 RGD
involved in response to muscle stretch IEP
IEP: 通过表达模式推断
16087782 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
15218324 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Ddr2 蛋白结构

FA58C

FA58C: cd00057 (31 - 183)

PKc_like

PKc_like: cl21453 (556 - 849)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 854 a.a.
蛋白主名 其他名称

discoidin domain-containing receptor 2

CD167b antigen

discoidin domain receptor family, member 2

neurotrophic tyrosine kinase, receptor-related 3

receptor protein-tyrosine kinase TKT

tyrosine-protein kinase TYRO 10

重组 Ddr2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75297 DDR2 Protein, Rat (HEK293, His) B1WC09 (Q24-R399) ≥95%
HY-P75298 DDR2 Protein, Rat (HEK293, hFc) B1WC09 (Q24-R399) ≥95%

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-16961 Sitravatinib Inhibitor 99.57% Phase 3
HY-16961A Sitravatinib malate Inhibitor / Phase 3
Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-114169 WRG-28 Inhibitor 99.34% 否
HY-135401 VU6015929 Inhibitor 99.50% 否
HY-114311 FGFR1/DDR2 inhibitor 1 Inhibitor 98.26% 否
HY-114173 DDR1-IN-4 Inhibitor 98.19% 否
HY-156552 DDR1/2 inhibitor-2 Inhibitor 99.73% 否
HY-14979A ML786 dihydrochloride Inhibitor / 否
HY-162102 DDR1-IN-8 Inhibitor / 否
HY-13979A DDR1-IN-1 dihydrochloride Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ddr2 NCBI NCBI:4921
Mus musculus Ddr2 NCBI NCBI:18214
Macaca mulatta Ddr2 NCBI NCBI:720124
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