Ddr2 - discoidin domain receptor family, member 2 Gene

中文名称：盘状结构域受体家族，成员 2

种属: Mus musculus

同用名: Ntrkr3; tyro10

关于 Ddr2

功能概要

该基因编码的蛋白可启动胶原蛋白结合活性和蛋白酪氨酸激酶胶原蛋白受体活性。参与多个过程，包括软骨细胞增殖；胶原纤维组织；和胶原蛋白激活的酪氨酸激酶受体信号通路。在细胞群增殖的正调控上游或正调控内起作用；蛋白质自身磷酸化；和跨膜受体蛋白酪氨酸激酶信号通路。预测位于肌动蛋白细胞骨架和顶端质膜。预计是受体复合体的一部分。预计是质膜的组成部分。在消化系统中表达；中枢神经系统;泌尿生殖系统；和视网膜。该基因的人类直系同源物与胃肠道系统癌症有关（多个）；骨关节炎;和脊椎骨骨骺发育不良，短肢手型。与人类 DDR2（盘状蛋白结构域受体酪氨酸激酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables collagen binding activity and protein tyrosine kinase collagen receptor activity. Involved in several processes, including chondrocyte proliferation; collagen fibril organization; and collagen-activated tyrosine kinase receptor signaling pathway. Acts upstream of or within positive regulation of cell population proliferation; protein autophosphorylation; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in actin Cytoskeleton and apical plasma membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in alimentary system; central nervous system; genitourinary system; and retina. Human ortholog(s) of this gene implicated in gastrointestinal system Cancer (multiple); osteoarthritis; and spondylometaepiphyseal dysplasia, short limb-hand type. Orthologous to human DDR2 (Discoidin Domain Receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]