TDO2 - tryptophan 2,3-dioxygenase Gene

中文名称：色氨酸 2,3-双加氧酶

种属: Homo sapiens

同用名: TO; TDO; TPH2; TRPO; HYPTRP

基因 ID: 6999 | 基因类型: protein coding

关于 TDO2

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:155,903,696-155,920,406 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 223 orthologues and is associated with 2 phenotypes. Biased expression in liver (RPKM 202.8) and appendix (RPKM 14.2).

功能概要

该基因编码一种血红素酶，该酶通过催化犬尿氨酸途径的第一步和限速步骤在色氨酸代谢中发挥关键作用。编码蛋白活性的增加和随后犬尿氨酸的产生也可能通过抑制抗肿瘤免疫反应在癌症中发挥作用，并且该基因中的单核苷酸多态性可能与自闭症有关。[RefSeq 提供，2012 年 2 月]

This gene encodes a heme Enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in Cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]

TDO2 基因产物(1)

mRNA	Protein	Name
NM_005651.4	NP_005642.1	tryptophan 2,3-dioxygenase

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables heme binding	IDA IDA: 通过直接分析推断	27762317	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	24722188	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables tryptophan 2,3-dioxygenase activity	IDA IDA: 通过直接分析推断	27762317	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in protein homotetramerization	IDA IDA: 通过直接分析推断	27762317	GOA
involved in tryptophan catabolic process to kynurenine	IDA IDA: 通过直接分析推断	27762317	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TDO2 蛋白结构

Trp_dioxygenase

0
100
200
300
406 a.a.

蛋白主名

其他名称

tryptophan 2,3-dioxygenase

tryptamin 2,3-dioxygenase

TDO2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TDO2	P48775	NGB	Homo sapiens	Q9NPG2	Validated Y2H	32296183
种属内	TDO2	P48775	NGB	Homo sapiens	Q9NPG2	Y2H Array	25416956
种属内	TDO2	P48775	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
种属内	TDO2	P48775	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
种属内	TDO2	P48775	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
种属内	TDO2	P48775	PM20D2	Homo sapiens	Q8IYS1	Validated Y2H	32296183
种属内	TDO2	P48775	AHCYL1	Homo sapiens	O43865	Validated Y2H	32814053
种属内	TDO2	P48775	AHCYL1	Homo sapiens	O43865	Y2H Pooling	32814053
种属内	TDO2	P48775	AHCYL1	Homo sapiens	O43865	Y2H Array	32814053
种属内	TDO2	P48775	NR1D1	Homo sapiens	P20393	Y2H Array	32296183
种属内	TDO2	P48775	NR1D1	Homo sapiens	P20393	Y2H Prey Pooling	32296183
种属内	TDO2	P48775	NMNAT1	Homo sapiens	Q9HAN9	Validated Y2H	32296183
种属内	TDO2	P48775	NMNAT1	Homo sapiens	Q9HAN9	Y2H Array	32296183
种属内	TDO2	P48775	NMNAT1	Homo sapiens	Q9HAN9	Y2H Prey Pooling	32296183
种属内	TDO2	P48775	NMNAT1	Homo sapiens	Q9HAN9	Y2H Array	24722188
种属内	TDO2	P48775	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
种属内	TDO2	P48775	SDCBP	Homo sapiens	O00560	Y2H Array	24722188
种属内	TDO2	P48775	CDH1	Homo sapiens	P12830	Y2H Array	32814053
种属内	TDO2	P48775	CDH1	Homo sapiens	P12830	Y2H Pooling	32814053
种属内	TDO2	P48775	CDH1	Homo sapiens	P12830	Validated Y2H	32814053
种属内	TDO2	P48775	EIF4E	Homo sapiens	P06730	Y2H Prey Pooling	25416956
种属内	TDO2	P48775	EIF4E	Homo sapiens	P06730	Validated Y2H	25416956
种属内	TDO2	P48775	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
种属内	TDO2	P48775	SDCBP2	Homo sapiens	Q9H190	Y2H Array	31515488
种属内	TDO2	P48775	SDCBP2	Homo sapiens	Q9H190	Y2H Prey Pooling	25416956
种属内	TDO2	P48775	SDCBP2	Homo sapiens	Q9H190	Validated Y2H	25416956
种属内	TDO2	P48775	SDCBP2	Homo sapiens	Q9H190	Y2H Array	25416956
种属内	TDO2	P48775	ASMTL	Homo sapiens	O95671	Anti Tag CoIP	33961781
种属内	TDO2	P48775	ASMTL	Homo sapiens	O95671	Validated Y2H	25416956
种属内	TDO2	P48775	ASMTL	Homo sapiens	O95671	Anti Tag CoIP	28514442
种属内	TDO2	P48775	ASMTL	Homo sapiens	O95671	Y2H Array	25416956
种属内	TDO2	P48775	ASMTL	Homo sapiens	O95671	Y2H Prey Pooling	32296183
种属内	TDO2	P48775	ASMTL	Homo sapiens	O95671	Y2H Array	32296183
种属内	TDO2	P48775	ASMTL	Homo sapiens	O95671	Y2H Array	24722188
种属内	TDO2	P48775	ASMTL	Homo sapiens	O95671	Y2H Pooling	16189514
种属内	TDO2	P48775	TDO2	Homo sapiens	P48775	Y2H Array	32296183
种属内	TDO2	P48775	TDO2	Homo sapiens	P48775	Y2H Prey Pooling	32296183
种属内	TDO2	P48775	TDO2	Homo sapiens	P48775	Y2H Array	24722188
种属内	TDO2	P48775	TDO2	Homo sapiens	P48775	Validated Y2H	32296183
种属内	TDO2	P48775	TDO2	Homo sapiens	P48775	Y2H Array	25416956
种属内	TDO2	P48775	MOB1A	Homo sapiens	Q9H8S9	Validated Y2H	32296183
种属内	TDO2	P48775	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
种属内	TDO2	P48775	ZFYVE26	Homo sapiens	Q68DK2-5	Y2H Prey Pooling	25416956
种属内	TDO2	P48775	ZFYVE26	Homo sapiens	Q68DK2-5	Validated Y2H	25416956
种属内	TDO2	P48775	ZFYVE26	Homo sapiens	Q68DK2-5	Validated Y2H	32296183
种属内	TDO2	P48775	MOB3C	Homo sapiens	Q70IA8	Validated Y2H	25416956
种属内	TDO2	P48775	MOB3C	Homo sapiens	Q70IA8	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hypertryptophanemia

HYPTRP	Hypertryptophanemia, Familial
Familial Hypertryptophanemia

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Constipation

Schizophrenia 12

Sczd12

Schizophrenia Susceptibility Locus, Chromosome 1p-Related

Acute Porphyria

Porphyrias, Hepatic	Hepatic Porphyria
Porphyria Hepatic	Acute Intermittent Porphyria

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Variegate Porphyria

Porphyria Variegata	Protoporphyrinogen Oxidase Deficiency
VP	Ppox Deficiency
Porphyria, South African Type	Porphyria Variegata, Susceptibility To
Protocoproporphyria	Porphyria Variegate
Porphyria South African Type	Pv
Porphyria, Variegate	Vp - [Variegate Porphyria]

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-114319	β-Cembrenediol	Inhibitor	/	否
HY-161348	AT-0174	Inhibitor	/	否
HY-161996	IDO1-IN-25	Inhibitor	/	否
HY-RS14331	TDO2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-170322	human TDO2-IN-1		/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	TDO2	VGNC	VGNC:47217
Rattus norvegicus	TDO2	RGD	RGD:68370
Mus musculus	TDO2	MGD	MGI:1928486
Bos taurus	TDO2	VGNC	VGNC:35712
Macaca mulatta	TDO2	VGNC	VGNC:78298
Felis catus	TDO2	VGNC	VGNC:66044

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TDO2 - tryptophan 2,3-dioxygenase Gene

关于 TDO2

功能概要

TDO2 基因产物(1)

TDO2 蛋白结构

TDO2 蛋白互作信息

关联疾病

直系同源

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TDO2 - tryptophan 2,3-dioxygenase Gene

关于 TDO2

功能概要

TDO2 基因产物(1)

TDO2 蛋白结构

TDO2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z