NR1D1 - nuclear receptor subfamily 1 group D member 1 Gene

中文名称：核受体亚家族 1 D 组成员 1

种属: Homo sapiens

同用名: EAR1; hRev; THRA1; THRAL; ear-1; REVERBA; REVERBalpha

基因 ID: 9572 | 基因类型: protein coding

关于 NR1D1

Cytogenetic location: 17q21.1 Genomic coordinates (GRCh38): 17:40,092,793-40,100,589 (from NCBI)

This gene has 1 transcript (splice variant), 378 orthologues and 18 paralogues. Ubiquitous expression in ovary (RPKM 21.5), brain (RPKM 21.4) and 24 other tissues.

功能概要

该基因编码的转录因子是核受体亚家族 1 的成员。所编码的蛋白质是配体敏感的转录因子，负向调节核心时钟蛋白的表达。特别是这种蛋白质抑制生物钟转录因子芳烃受体核易位蛋白样蛋白 1 (ARNTL) 。这种蛋白质还可能参与调节在代谢、炎症和心血管过程中起作用的基因。[RefSeq 提供，2013 年 1 月]

This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor Aryl Hydrocarbon Receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013]

NR1D1 基因产物(1)

mRNA	Protein	Name
NM_021724.5	NP_068370.1	nuclear receptor subfamily 1 group D member 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	8622974	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	15761026	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: 通过突变表型推断	8622974	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	19955433	GOA
enables heme binding	IDA IDA: 通过直接分析推断	18006707	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17892483	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	18511497	GOA
enables transcription corepressor binding	IDA IDA: 通过直接分析推断	15761026	GOA
enables transcription corepressor binding	IMP IMP: 通过突变表型推断	18006707	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to lipopolysaccharide	IMP IMP: 通过突变表型推断	18511497	GOA
NOT involved in cholesterol homeostasis	IDA IDA: 通过直接分析推断	18511497	GOA
involved in intracellular glucose homeostasis	IMP IMP: 通过突变表型推断	18006707	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	15761026	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	18006707	GOA
involved in negative regulation of toll-like receptor 4 signaling pathway	IMP IMP: 通过突变表型推断	18511497	GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	19955433	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	8622974	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	18511497	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromatin	IDA IDA: 通过直接分析推断	18511497	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NR1D1 蛋白结构

zf-C4

Hormone_recep

0
100
200
300
400
500
614 a.a.

蛋白主名

其他名称

nuclear receptor subfamily 1 group D member 1

Rev-ErbAalpha

NR1D1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NR1D1	P20393	APOA4	Homo sapiens	P06727	Confocal	24311788
种属内	NR1D1	P20393	APOA4	Homo sapiens	P06727	Anti Tag CoIP	24311788
种属内	NR1D1	P20393	APOA4	Homo sapiens	P06727	PLA	24311788
种属内	NR1D1	P20393	NCOR1	Homo sapiens	O75376	Y2H	20581824
种属内	NR1D1	P20393	NCOR1	Homo sapiens	O75376	X-Ray Diffraction	20581824
种属内	NR1D1	P20393	NCOR1	Homo sapiens	O75376	FRET	20581824
种属内	NR1D1	P20393	HUWE1	Homo sapiens	Q7Z6Z7	Anti Bait CoIP	20534529
种属内	NR1D1	P20393	HUWE1	Homo sapiens	Q7Z6Z7	Anti Tag CoIP	20534529
种属内	NR1D1	P20393	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
种属内	NR1D1	P20393	TDO2	Homo sapiens	P48775	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

NR1D1 抗体

目录号	产品名	应用	反应物种
HY-P81681	NR1D1 Antibody (YA1426)	WB, ICC/IF	Human, Mouse, Rat

关联疾病

疾病名称

别名

Hypothyroidism, Congenital, Nongoitrous, 6

CHNG6	Congenital Nongoitrous Hypothyroidism 6
Hypothyroidism, Congenital, Non-Goitrous, 6	Hypothyroidism, Congenital, Nongoitrous, Type 6

Rem Sleep Behavior Disorder

Rapid Eye Movement Sleep Behavior Disorder	Rem Sleep Behaviour Disorder
Rapid Eye Movement Sleep Behaviour Disorder	Rem - [Rapid Eye Movement] Behaviour Disorder

Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome	Delayed Sleep Phase Syndrome, Susceptibility To
DSPD	Delayed Sleep Phase Disorder, Susceptibility To
DSPS	Sleep Phase, Delayed, Disorder
Sleep Phase Syndrome, Delayed, Susceptibility To

Advanced Sleep Phase Syndrome

Fasps	Familial Advanced Sleep-Phase Syndrome
Advanced Sleep Phase Syndrome, Familial	Familial Advanced Sleep Phase Syndrome
Sleep Phase Syndrome, Advanced, Familial	Advanced Sleep-Phase Syndrome, Familial

Brachydactyly, Type E1

Brachydactyly Type E1	Brachydactyly Type E
BDE1	Brachydactyly, Type E
Bde	Type E Brachydactyly
Brachydactyly E1	Brachydactyly Syndrome Type E

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Sleep Disorder

Sleep Disorders

Non-Organic Sleep Disorder

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09527	NR1D1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	NR1D1	VGNC	VGNC:32228
Mus musculus	NR1D1	MGD	MGI:2444210
Rattus norvegicus	NR1D1	RGD	RGD:628827
Macaca mulatta	NR1D1	VGNC	VGNC:75502
Canis familiaris	NR1D1	VGNC	VGNC:43940
Felis catus	NR1D1	VGNC	VGNC:68542

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