2. Gene
  3. TRPC5 - transient receptor potential cation channel subfamily C member 5 Gene

TRPC5 - transient receptor potential cation channel subfamily C member 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：瞬时受体电位阳离子通道亚家族 C 成员 5

种属: Homo sapiens

同用名: TRP5; PPP1R159

基因 ID: 7224 | 基因类型: protein coding

关于 TRPC5

Cytogenetic location: Xq23 Genomic coordinates (GRCh38): X:111,768,011-112,082,776 (from NCBI)

This gene has 1 transcript (splice variant), 228 orthologues and 5 paralogues. Low expression observed in reference dataset.

功能概要

该基因属于瞬时受体家族。它编码七种哺乳动物 TRPC (瞬时受体电位通道) 蛋白之一。编码的蛋白质是一种多通道膜蛋白，被认为形成了受体激活的非选择性钙渗透阳离子通道。该蛋白质单独或作为与 TRPC1、TRPC3 和 TRPC4 的异源多聚体组装体具有活性。它还与多种蛋白质相互作用，包括钙调蛋白、CABP1、enkurin、Na (+) -H+ 交换调节因子 (NHERF) 、干扰素诱导的 GTP 结合蛋白 (MX1) 、无名指蛋白 24 (RNF24) 和 SEC14 结构域和血影蛋白含重复蛋白 1 (SESTD1) 。[RefSeq 提供，2010 年 5 月]

This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including Calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010]

TRPC5 基因产物(1)

mRNA Protein Name
NM_012471.3 NP_036603.1 short transient receptor potential channel 5
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium channel activity IDA
IDA: 通过直接分析推断
20164195 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20164195 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of calcium channel complex IDA
IDA: 通过直接分析推断
20164195 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRPC5 蛋白结构

Ank_2

Ank_2: Ankyrin repeats (3 copies) (38 - 118)

Ank

Ank: Ankyrin repeat (143 - 164)

TRP_2

TRP_2: Transient receptor ion channel II (176 - 238)

Ion_trans

Ion_trans: Ion transport protein (406 - 624)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 973 a.a.
蛋白主名 其他名称

short transient receptor potential channel 5

TRP-5

关联疾病

疾病名称 别名
Pyloric Stenosis
Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques

Olmsted Syndrome

Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques

Palmoplantar And Periorificial Keratoderma

Olms
Familial Episodic Pain Syndrome

Feps
Pseudohypoaldosteronism
Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (8)
目录号 产品名 作用方式
纯度 是否罕见病
HY-17386 Rosiglitazone 99.94% 是
HY-14600 Rosiglitazone maleate 99.88% 是
HY-30234A Clemizole hydrochloride 99.99% 是
HY-17386A Rosiglitazone hydrochloride 99.31% 是
HY-17386B Rosiglitazone potassium / 否
HY-14600R Rosiglitazone maleate (Standard) / 否
HY-30234 Clemizole / 否
HY-B0700 Rosiglitazone sodium / 否
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-162584 TRPC4/5-IN-2 Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (20)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101507 Pico145 Inhibitor 99.40% 否
HY-12949 ML204 Inhibitor 99.08% 否
HY-112302 HC-070 Antagonist 99.73% 否
HY-122051 AC1903 Inhibitor 99.80% 否
HY-133168 Englerin A Activator 99.50% 否
HY-128205 BTD Inhibitor 99.78% 否
HY-12949A ML204 hydrochloride Inhibitor 99.70% 否
HY-132813 Evifacotrep Antagonist 99.55% 否
HY-133012 GFB-8438 Inhibitor 98.41% 否
HY-128561 AM12 Activator / 否
HY-142030 TRPC5 modulator-1 Modulator / 否
HY-144205 TRPC5-IN-2 Inhibitor / 否
HY-144208 TRPC5-IN-3 Inhibitor / 否
HY-144429 TRPC5-IN-4 Inhibitor / 否
HY-145150 TRPC5-IN-1 Inhibitor / 否
HY-146155 TRPC4/5-IN-1 Inhibitor / 否
HY-162090 TRPC antagonist 1 Antagonist / 否
HY-17386S Rosiglitazone-d3 / 否
HY-RS15108 TRPC5 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-17386S1 Rosiglitazone-d4 / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus TRPC5 VGNC VGNC:66585
Rattus norvegicus TRPC5 RGD RGD:619787
Bos taurus TRPC5 VGNC VGNC:36385
Canis familiaris TRPC5 VGNC VGNC:47870
Mus musculus TRPC5 MGD MGI:109524
Macaca mulatta TRPC5 VGNC VGNC:78653
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