Sting1 - stimulator of interferon response cGAMP interactor 1 Gene

中文名称：干扰素反应刺激物 cGAMP 相互作用物 1

种属: Mus musculus

同用名: ERIS; MPYS; Mita; STING; Tmem173; STING-beta; 2610307O08Rik

关于 Sting1

功能概要

该基因编码的蛋白可启动 2',3'-环状 GMP-AMP 结合活性； cyclic-di-GMP 结合活性；和泛素蛋白连接酶结合活性。参与多个过程，包括对其他生物体的防御反应；巨自噬；和干扰素-β产生的正调节。在对干扰素-β 的细胞反应的上游或内部起作用； RNA 聚合酶 II 对转录的正调控；和炎症反应的调节。位于多种细胞成分中，包括自噬体；细胞质的核周区；和过氧化物酶体。在输精管中表达；附睾;回肠;和前列腺。该基因的人类直系同源基因与婴儿期发病的 STING 相关血管病变有关。与人类 STING1（干扰素反应刺激物 cGAMP 相互作用物 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables 2',3'-cyclic GMP-AMP binding activity; cyclic-di-GMP binding activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including defense response to Other organism; macroautophagy; and positive regulation of interferon-beta production. Acts upstream of or within cellular response to interferon-beta; positive regulation of transcription by RNA polymerase II; and regulation of inflammatory response. Located in several cellular components, including autophagosome; perinuclear region of cytoplasm; and peroxisome. Is expressed in ductus deferens; epididymis; ileum; and prostate gland. Human ortholog(s) of this gene implicated in STING-associated vasculopathy with onset in infancy. Orthologous to human STING1 (stimulator of interferon response cGAMP interactor 1). [provided by Alliance of Genome Resources, Apr 2022]