Tbk1 - TANK-binding kinase 1 Gene

中文名称：TANK 结合激酶 1

种属: Mus musculus

同用名: 1200008B05Rik

关于 Tbk1

功能概要

该基因编码的蛋白可启动多种功能，包括相同的蛋白质结合活性；蛋白磷酸酶结合活性；和蛋白丝氨酸/苏氨酸激酶活性。参与基因表达的负调控；肽基丝氨酸磷酸化；防御反应的积极调节。作用于多个过程的上游或内部，包括对革兰氏阳性菌的防御反应；树突状细胞增殖；和干扰素-β产生的正调节。预测位于核质中。预计在细胞质中有活性。以多种结构表达，包括消化系统；脑;泌尿生殖系统；呼吸系统;和感觉器官。该基因的人类直系同源物与脑部疾病和额颞叶痴呆和/或肌萎缩侧索硬化症 4 有关。与人类 TBK1（TANK 结合激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including identical protein binding activity; protein Phosphatase binding activity; and protein serine/threonine kinase activity. Involved in negative regulation of gene expression; peptidyl-serine phosphorylation; and positive regulation of defense response. Acts upstream of or within several processes, including defense response to Gram-positive bacterium; dendritic cell proliferation; and positive regulation of interferon-beta production. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in brain disease and frontotemporal dementia and/or amyotrophic lateral sclerosis-4. Orthologous to human TBK1 (TANK binding kinase 1). [provided by Alliance of Genome Resources, Apr 2022]