Ticam1 - toll-like receptor adaptor molecule 1 Gene

种属: Mus musculus

同用名: TRIF; TICAM-1

基因 ID: 106759 | 基因类型: protein coding

关于 Ticam1

功能概要

Predicted to enable protein kinase binding activity. Involved in several processes, including TRIF-dependent Toll-like Receptor signaling pathway; cellular response to oxidised low-density lipoprotein particle stimulus; and positive regulation of cytokine production. Acts upstream of or within several processes, including positive regulation of cytokine production; positive regulation of lymphocyte activation; and positive regulation of nitrogen compound metabolic process. Located in cytosol and mitochondrion. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human TICAM1 (toll like receptor adaptor molecule 1). [provided by Alliance of Genome Resources, Apr 2022]

Ticam1 基因产物(1)

mRNA	Protein	Name
NM_174989.5	NP_778154.1	TIR domain-containing adapter molecule 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	14517278	MGI
enables signaling adaptor activity	IDA IDA: 通过直接分析推断	21441935	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of B cell activation	IMP IMP: 通过突变表型推断	12855817	MGI
acts upstream of B cell proliferation	IMP IMP: 通过突变表型推断	12855817	MGI
acts upstream of or within MyD88-independent toll-like receptor signaling pathway	IMP IMP: 通过突变表型推断	12855817	MGI
involved in TRIF-dependent toll-like receptor signaling pathway	IMP IMP: 通过突变表型推断	17658277	MGI
acts upstream of or within apoptotic signaling pathway	IMP IMP: 通过突变表型推断	12872135	MGI
involved in cellular response to lipopolysaccharide	IMP IMP: 通过突变表型推断	17658277	MGI
involved in cellular response to oxidised low-density lipoprotein particle stimulus	IMP IMP: 通过突变表型推断	20037584	MGI
acts upstream of chemokine production	IGI IGI: 通过遗传相互作用推断	12855817	MGI
acts upstream of chemokine production	IMP IMP: 通过突变表型推断	12855817	MGI
acts upstream of or within defense response to virus	IMP IMP: 通过突变表型推断	12872135	MGI
acts upstream of interferon-beta production	IMP IMP: 通过突变表型推断	12855817	MGI
acts upstream of interleukin-6 production	IMP IMP: 通过突变表型推断	12855817	MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway	IMP IMP: 通过突变表型推断	12855817	MGI
acts upstream of or within macrophage activation involved in immune response	IMP IMP: 通过突变表型推断	12872135	MGI
acts upstream of macrophage cytokine production	IDA IDA: 通过直接分析推断	12872135	MGI
acts upstream of macrophage cytokine production	IGI IGI: 通过遗传相互作用推断	12872135	MGI
acts upstream of macrophage cytokine production	IMP IMP: 通过突变表型推断	12855817	MGI
acts upstream of nitric oxide biosynthetic process	IMP IMP: 通过突变表型推断	12872135	MGI
acts upstream of or within positive regulation of B cell activation	IMP IMP: 通过突变表型推断	12855817	MGI
acts upstream of or within positive regulation of B cell proliferation	IMP IMP: 通过突变表型推断	12855817	MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity	IGI IGI: 通过遗传相互作用推断	12855817	MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity	IMP IMP: 通过突变表型推断	12855817	MGI
involved in positive regulation of autophagy	IMP IMP: 通过突变表型推断	17658277	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IGI IGI: 通过遗传相互作用推断	12855817	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: 通过突变表型推断	12855817	MGI
acts upstream of or within positive regulation of chemokine production	IGI IGI: 通过遗传相互作用推断	12855817	MGI
acts upstream of or within positive regulation of chemokine production	IMP IMP: 通过突变表型推断	12855817	MGI
involved in positive regulation of cytokine production involved in inflammatory response	IMP IMP: 通过突变表型推断	20037584	MGI
involved in positive regulation of gene expression	IGI IGI: 通过遗传相互作用推断	20037584	MGI
involved in positive regulation of gene expression	IMP IMP: 通过突变表型推断	20037584	MGI
acts upstream of or within positive regulation of interferon-beta production	IMP IMP: 通过突变表型推断	12855817	MGI
acts upstream of or within positive regulation of interleukin-6 production	IMP IMP: 通过突变表型推断	12855817	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IDA IDA: 通过直接分析推断	12872135	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IGI IGI: 通过遗传相互作用推断	12872135	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IMP IMP: 通过突变表型推断	12855817	MGI
involved in positive regulation of myeloid dendritic cell cytokine production	IMP IMP: 通过突变表型推断	21703541	MGI
acts upstream of or within positive regulation of natural killer cell activation	IMP IMP: 通过突变表型推断	21059856	MGI
acts upstream of or within positive regulation of nitric oxide biosynthetic process	IMP IMP: 通过突变表型推断	12872135	MGI
acts upstream of or within positive regulation of protein binding	IDA IDA: 通过直接分析推断	19734906	MGI
acts upstream of or within positive regulation of protein ubiquitination	IDA IDA: 通过直接分析推断	19734906	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IDA IDA: 通过直接分析推断	12872135	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IGI IGI: 通过遗传相互作用推断	12872135	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IMP IMP: 通过突变表型推断	12855817	MGI
acts upstream of or within positive regulation of type I interferon production	IMP IMP: 通过突变表型推断	12872135	MGI
acts upstream of or within regulation of protein-containing complex assembly	IMP IMP: 通过突变表型推断	12872135	MGI
acts upstream of or within response to exogenous dsRNA	IDA IDA: 通过直接分析推断	12872135	MGI
acts upstream of or within response to exogenous dsRNA	IMP IMP: 通过突变表型推断	12855817	MGI
involved in response to exogenous dsRNA	IMP IMP: 通过突变表型推断	21703541	MGI
acts upstream of or within response to lipopolysaccharide	IGI IGI: 通过遗传相互作用推断	12872135	MGI
acts upstream of or within response to lipopolysaccharide	IMP IMP: 通过突变表型推断	12855817	MGI
acts upstream of tumor necrosis factor production	IDA IDA: 通过直接分析推断	12872135	MGI
acts upstream of tumor necrosis factor production	IGI IGI: 通过遗传相互作用推断	12872135	MGI
acts upstream of tumor necrosis factor production	IMP IMP: 通过突变表型推断	12855817	MGI
acts upstream of type I interferon production	IMP IMP: 通过突变表型推断	12872135	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	21703541	MGI
located in mitochondrion	IDA IDA: 通过直接分析推断	21703541	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

TIR domain-containing adapter molecule 1

TIR domain-containing adapter protein inducing IFN-beta	TIR domain-containing adaptor inducing interferon-beta
toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta

Ticam1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	Ticam1	Q80UF7	Btk	Mus musculus	P35991	Anti Tag CoIP	21441935
种属内	Ticam1	Q80UF7	Tbk1	Mus musculus	Q9WUN2	Anti Bait CoIP	22454496

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14517	TICAM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Ticam1	NCBI	NCBI:148022

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Ticam1 - toll-like receptor adaptor molecule 1 Gene

关于 Ticam1

功能概要

Ticam1 基因产物(1)

Ticam1 蛋白互作信息

直系同源

热门区域

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Ticam1 - toll-like receptor adaptor molecule 1 Gene

关于 Ticam1

功能概要

Ticam1 基因产物(1)

Ticam1 蛋白互作信息

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z