2. Gene
  3. USF1 - upstream transcription factor 1 Gene

USF1 - upstream transcription factor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：上游转录因子 1

种属: Homo sapiens

同用名: UEF; FCHL; MLTF; FCHL1; MLTFI; HYPLIP1; bHLHb11

基因 ID: 7391 | 基因类型: protein coding

关于 USF1

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:161,039,251-161,045,977 (from NCBI)

This gene has 11 transcripts (splice variants), 220 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 29.9), lymph node (RPKM 25.8) and 25 other tissues.

功能概要

该基因编码基本螺旋-环-螺旋亮氨酸拉链家族的成员，可作为细胞转录因子发挥作用。编码的蛋白质可以通过富含嘧啶的引发剂 (Inr) 元件和 E-box 基序激活转录。该基因与家族性联合高脂血症 (FCHL) 有关。该基因的可变剪接导致多个转录变体。在 21 号染色体上定义了一个相关的假基因。[RefSeq 提供，2013 年 2 月]

This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013]

USF1 基因产物(3)

mRNA Protein Name
NM_001276373.2 NP_001263302.1 upstream stimulatory factor 1 isoform 1
NM_007122.5 NP_009053.1 upstream stimulatory factor 1 isoform 1
NM_207005.3 NP_996888.1 upstream stimulatory factor 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: 通过突变表型推断
7852331 GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
2249772 GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
IMP: 通过突变表型推断
8576131 GOA
enables bHLH transcription factor binding IPI
IPI: 通过物理相互作用推断
8576131 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
19303849 GOA
enables histone deacetylase binding IPI
IPI: 通过物理相互作用推断
19303849 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19303849 GOA
enables protein heterodimerization activity IPI
IPI: 通过物理相互作用推断
8576131 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
8576131 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
19303849 GOA
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
27141965 GOA
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
2249772 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to glucose stimulus IMP
IMP: 通过突变表型推断
7852331 GOA
involved in cellular response to insulin stimulus IDA
IDA: 通过直接分析推断
19303849 GOA
involved in glucose mediated signaling pathway IMP
IMP: 通过突变表型推断
7852331 GOA
involved in late viral transcription IDA
IDA: 通过直接分析推断
2249772 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
7852331 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
2249772 GOA
involved in response to hypoxia IMP
IMP: 通过突变表型推断
12917334 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
27141965 GOA
located in nucleus IDA
IDA: 通过直接分析推断
2249772 GOA
part of transcription regulator complex IDA
IDA: 通过直接分析推断
19303849 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

USF1 蛋白结构

HLH

HLH: Helix-loop-helix DNA-binding domain (200 - 254)

  • 0
  • 100
  • 200
  • 310 a.a.
蛋白主名 其他名称

upstream stimulatory factor 1

class B basic helix-loop-helix protein 11

USF1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
USF1 P22415 FOS Homo sapiens Q6FG41
Validated Y2H
25416956
种属内
USF1 P22415 FOS Homo sapiens Q6FG41
Y2H Array
25416956
种属内
USF1 P22415 FOS Homo sapiens Q6FG41
Y2H Prey Pooling
25416956
种属内
USF1 P22415 MAP3K7CL Homo sapiens P57077-4
Validated Y2H
32296183
种属内
USF1 P22415 MAP3K7CL Homo sapiens P57077-4
Y2H Array
32296183
种属内
USF1 P22415 MAP3K7CL Homo sapiens P57077-4
Y2H Prey Pooling
32296183
种属内
USF1 P22415 USF1 Homo sapiens P22415
Y2H Prey Pooling
32296183
种属内
USF1 P22415 PRKDC Homo sapiens P78527
Anti Tag CoIP
19303849
种属内
USF1 P22415 USF1 Homo sapiens P22415
Y2H Array
32296183
种属内
USF1 P22415 KAT2B Homo sapiens Q92831
Anti Bait CoIP
19303849
种属内
USF1 P22415 FOSL1 Homo sapiens P15407
Y2H Array
32296183
种属内
USF1 P22415 USF1 Homo sapiens P22415
Y2H Array
25416956
种属内
USF1 P22415 USF2 Homo sapiens Q15853
Anti Bait CoIP
19303849
种属内
USF1 P22415 KAT2B Homo sapiens Q92831
Anti Tag CoIP
19303849
种属内
USF1 P22415 PRKDC Homo sapiens P78527
Anti Bait CoIP
19303849
种属内
USF1 P22415 FOSL1 Homo sapiens P15407
Y2H Prey Pooling
32296183
种属内
USF1 P22415 USF2 Homo sapiens Q15853
Anti Tag CoIP
19303849
种属内
USF1 P22415 USF2 Homo sapiens Q15853
Anti Tag CoIP
33961781
种属内
USF1 P22415 KAT2B Homo sapiens Q92831
Acetylase Assay
19303849
种属内
USF1 P22415 USF1 Homo sapiens P22415
Validated Y2H
32296183
种属内
USF1 P22415 LAP3 Homo sapiens P28838
Y2H Prey Pooling
32296183
种属内
USF1 P22415 LAP3 Homo sapiens P28838
Validated Y2H
32296183
种属内
USF1 P22415 LAP3 Homo sapiens P28838
Y2H Array
32296183
种属内
USF1 P22415 FGFR3 Homo sapiens P22607
Y2H Array
32814053
种属内
USF1 P22415 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
种属内
USF1 P22415 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
种属内
USF1 P22415 HRAS Homo sapiens P01112
Validated Y2H
32814053
种属内
USF1 P22415 HRAS Homo sapiens P01112
Y2H Pooling
32814053
种属内
USF1 P22415 HRAS Homo sapiens P01112
Y2H Array
32814053
种属内
USF1 P22415 SNW1 Homo sapiens Q13573
Y2H Array
32296183
种属内
USF1 P22415 SNW1 Homo sapiens Q13573
Y2H Prey Pooling
32296183
种属内
USF1 P22415 SNW1 Homo sapiens Q13573
Validated Y2H
32296183
种属内
USF1 P22415 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32814053
种属内
USF1 P22415 UBQLN1 Homo sapiens Q9UMX0
Y2H Pooling
32814053
种属内
USF1 P22415 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 USF1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700514 USF1 Protein, Human (His) P22415 (G3-N310) ≥95%

关联疾病

疾病名称 别名
Hyperlipidemia, Familial Combined, 1

Hyperlipidemia, Familial Combined, Susceptibility To

Hyperlipidemia, Combined, 1

Hyperlipidemia, Familial Combined

FCHL1

Hyplip1

Familial Combined Hyperlipidemia Type 1

Hyperlipidemia Combined, 1

Hyperlipoproteinemia Type Iib
Hyperlipidemia, Familial Combined, 3

Familial Combined Hyperlipidemia

Combined Hyperlipidemia, Familial

Mixed Hyperlipidaemia

FCHL3

Hyperlipidemia, Familial Combined

Familial Multiple Lipoprotein-Type Hyperlipidemia

Hyperbetalipoproteinemia With Prebetalipoproteinemia

Type Iib Hyperlipoproteinemia

Hyperlipidemia Familial Combined

Hyperlipoproteinemia Type Iib

Mixed Hyperlipemia

Hyperlipidaemia, Group C

Familial Hypercholesterolaemia With Hyperlipaemia

Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia

Hyperbetalipoproteinaemia With Prebetalipoproteinaemia

Hypercholesterolaemia With Endogenous Hyperglyceridaemia

Prebetalipoproteinemia Hyperbetalipoproteinaemia

Remnant Hyperlipoproteinemia
Familial Hyperlipidemia

Familial Hyperlipoproteinemia

Hyperlipidaemia

Hyperlipoproteinemias

Hyperlipidemia

Hyperlipemia

Hyperlipidemias
Cowden Syndrome

Cowden Disease

Multiple Hamartoma Syndrome

Cowden'S Disease

Lhermitte-Duclos Disease

Cd

Cs

Mham

Dysplastic Gangliocytoma Of Cerebellum

Cowden'S Syndrome

Hamartoma Syndrome, Multiple
Lipid Metabolism Disorder

Dyslipidemia

Disorder Of Fatty Acid Metabolism

Lipid Metabolism Disorders

Fatty Acid Metabolism Disorder

Disorder Of Lipid Metabolism

Abnormality Of Lipid Metabolism

Lipid Metabolism, Inborn Errors

Dyslipidemias

Disorders Of Lipid Metabolism

Congenital Disorders Of Lipid Metabolism

Inherited Disorders Of Lipid Metabolism
Microphthalmia

Microphthalmos

Isolated Anophthalmia-Microphthalmia Syndrome

Isolated Microphthalmia-Anophthalmia-Coloboma

Simple Microphthalmos

Clinical Anophthalmia

Isolated Anophthalmia - Microphthalmia

Isolated Pure Microphthalmia

Mac Spectrum

Microphthalmia-Anophthalmia-Coloboma Spectrum

Primitive Anophthalmia

Globe Of Eye Small

Small Eyeball

Hypoplasia Of Eye

Isolated Nanophthalmos

Rudimentary Eye

Dysplasia Of Eye
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15513 USF1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris USF1 VGNC VGNC:53132
Bos taurus USF1 VGNC VGNC:55695
Macaca mulatta USF1 VGNC VGNC:100184
Rattus norvegicus USF1 RGD RGD:620974
Mus musculus USF1 MGD MGI:99542
Felis catus USF1 VGNC VGNC:107960
Others USF1 NCBI
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