2. Gene
  3. WNT8A - Wnt family member 8A Gene

WNT8A - Wnt family member 8A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Wnt 家族成员 8A

种属: Homo sapiens

同用名: WNT8D

基因 ID: 7478 | 基因类型: protein coding

关于 WNT8A

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,077,367-138,092,365 (from NCBI)

This gene has 4 transcripts (splice variants), 275 orthologues and 18 paralogues. Low expression observed in reference dataset.

功能概要

Wnt 基因家族由编码分泌信号蛋白的结构相关基因组成。这些蛋白质与肿瘤发生和几个发育过程有关，包括胚胎发生过程中细胞命运和模式的调节。该基因是 Wnt 基因家族的一员，可能与早期胚胎和生殖细胞肿瘤的发育有关。已发现该基因的多个选择性剪接转录物变体。[RefSeq 提供，2014 年 7 月]

The Wnt gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the Wnt gene family, and may be implicated in development of early embryos as well as germ cell tumors. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]

WNT8A 基因产物(3)

mRNA Protein Name
NM_001300938.2 NP_001287867.1 protein Wnt-8a isoform 1 precursor
NM_001300939.2 NP_001287868.1 protein Wnt-8a isoform 2 precursor
NM_058244.4 NP_490645.1 protein Wnt-8a isoform 3 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables receptor ligand activity IDA
IDA: 通过直接分析推断
28733458 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
28733458 GOA
involved in secondary palate development IMP
IMP: 通过突变表型推断
18413325 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

WNT8A 蛋白结构

wnt

wnt: wnt family (36 - 336)

  • 0
  • 100
  • 200
  • 300
  • 351 a.a.
蛋白主名 其他名称

protein Wnt-8a

WNT8d

关联疾病

疾病名称 别名
Norrie Disease

Atrophia Bulborum Hereditaria

Episkopi Blindness

Pseudoglioma

ND

Norrie-Warburg Disease

Anderson-Warburg Syndrome

Fetal Iritis Syndrome

Norrie Syndrome

Norrie-Warburg Syndrome

Ndp

Congenital Progressive Oculo-Acoustico-Cerebral Degeneration

Norrie'S Disease

Oligophrenia Microphthalmus

Pseudoglioma Congenita

Whitnall-Norman Syndrome
Exudative Vitreoretinopathy

Familial Exudative Vitreoretinopathy

Fevr

Criswick-Schepens Syndrome

Exudative Vitreoretinopathy, Familial

Vitreoretinopathy, Exudative )

Exudative Vitreoretinopathy 1
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15842 WNT8A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus WNT8A RGD RGD:1306312
Macaca mulatta WNT8A VGNC VGNC:78801
Mus musculus WNT8A MGD MGI:107924
Felis catus WNT8A VGNC VGNC:67085
Bos taurus WNT8A VGNC VGNC:36964
Canis familiaris WNT8A VGNC VGNC:48429
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