2. Gene
  3. WDR77 - WD repeat domain 77 Gene

WDR77 - WD repeat domain 77 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：WD 重复域 77

种属: Homo sapiens

同用名: p44; MEP50; MEP-50; HKMT1069; Nbla10071; p44/Mep50

基因 ID: 79084 | 基因类型: protein coding

关于 WDR77

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:111,439,890-111,449,256 (from NCBI)

This gene has 4 transcripts (splice variants), 214 orthologues and 9 paralogues. Ubiquitous expression in lymph node (RPKM 14.0), urinary bladder (RPKM 11.8) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种雄激素受体共激活因子，它与蛋白质精氨酸甲基转移酶 5 形成复合物，将几种剪接体 Sm 蛋白中的特定精氨酸修饰为二甲基精氨酸。所编码的蛋白质可能参与前列腺癌的早期阶段，大部分蛋白质位于良性细胞的核内，但位于癌细胞的细胞质内。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2015 年 11 月]

The protein encoded by this gene is an Androgen Receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate Cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in Cancer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

WDR77 基因产物(4)

mRNA Protein Name
NM_001317062.2 NP_001303991.1 methylosome protein 50 isoform 1
NM_001317063.2 NP_001303992.1 methylosome protein 50 isoform 3
NM_001317064.2 NP_001303993.1 methylosome protein 50 isoform 4
NM_024102.4 NP_077007.1 methylosome protein 50 isoform 2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables methyl-CpG binding IDA
IDA: 通过直接分析推断
25284789 GOA
enables nuclear receptor coactivator activity IGI
IGI: 通过遗传相互作用推断
12972618 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11756452 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
19188445 GOA
located in cytoplasm IGI
IGI: 通过遗传相互作用推断
12972618 GOA
located in cytosol IDA
IDA: 通过直接分析推断
18984161 GOA
part of methylosome IDA
IDA: 通过直接分析推断
11756452 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21081503 GOA
located in nucleus IGI
IGI: 通过遗传相互作用推断
12972618 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

WDR77 蛋白结构

WD40

WD40: WD domain, G-beta repeat (122 - 153)

WD40

WD40: WD domain, G-beta repeat (159 - 196)

WD40

WD40: WD domain, G-beta repeat (247 - 280)

  • 0
  • 100
  • 200
  • 300
  • 342 a.a.
蛋白主名 其他名称

methylosome protein 50

WD repeat-containing protein 77

WDR77 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
WDR77 Q9BQA1 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
种属内
WDR77 Q9BQA1 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
种属内
WDR77 Q9BQA1 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
种属内
WDR77 Q9BQA1 PRMT5 Homo sapiens O14744
Pull Down
11756452
种属内
WDR77 Q9BQA1 PRMT5 Homo sapiens O14744
Anti Bait CoIP
26763441
种属内
WDR77 Q9BQA1 PRMT5 Homo sapiens O14744
Anti Bait CoIP
20951943
种属内
WDR77 Q9BQA1 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
种属内
WDR77 Q9BQA1 HSPB1 Homo sapiens P04792
Y2H Array
32814053
种属内
WDR77 Q9BQA1 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
种属内
WDR77 Q9BQA1 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
种属内
WDR77 Q9BQA1 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
种属内
WDR77 Q9BQA1 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
种属内
WDR77 Q9BQA1 WFS1 Homo sapiens O76024
Y2H Array
32814053
种属内
WDR77 Q9BQA1 WFS1 Homo sapiens O76024
Validated Y2H
32814053
种属内
WDR77 Q9BQA1 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 WDR77 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71622 WDR77 Protein, Human (His-SUMO) Q9BQA1 (1M-312L) ≥95%

WDR77 抗体

目录号 产品名 应用 反应物种
HY-P80931 WDR77 Antibody (YA655) WB, ICC/IF Human, Mouse, Rat

关联疾病

疾病名称 别名
Sarcomatoid Transitional Cell Carcinoma

Transitional Cell Carcinoma, Sarcomatoid

Transitional Spindle Cell Carcinoma

Transitional Cell Carcinoma, Spindle Cell
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15798 WDR77 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta WDR77 VGNC VGNC:79820
Mus musculus WDR77 MGD MGI:1917715
Felis catus WDR77 VGNC VGNC:67056
Rattus norvegicus WDR77 RGD RGD:1310479
Bos taurus WDR77 VGNC VGNC:36921
Others WDR77 NCBI
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