TRAPPC6A - trafficking protein particle complex subunit 6A Gene

中文名称：运输蛋白颗粒复合物亚基 6A

种属: Homo sapiens

同用名: TRS33

基因 ID: 79090 | 基因类型: protein coding

关于 TRAPPC6A

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,162,933-45,178,237 (from NCBI)

Ubiquitous expression in kidney (RPKM 18.2), spleen (RPKM 12.2) and 25 other tissues.

功能概要

该基因编码运输蛋白颗粒复合物的一个组成部分，该复合物将囊泡输送到顺式高尔基体膜。小鼠相关基因表达的缺失会影响皮毛和眼睛的色素沉着，表明编码的蛋白质可能参与黑素体的生物发生。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2012 年 8 月]

This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. Loss of expression of the related gene in mouse affects coat and eye pigmentation, suggesting that the encoded protein may be involved in melanosome biogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

TRAPPC6A 基因产物(4)

mRNA	Protein	Name
NM_001270891.2	NP_001257820.1	trafficking protein particle complex subunit 6A isoform 2
NM_001270892.2	NP_001257821.1	trafficking protein particle complex subunit 6A isoform 3
NM_001270893.2	NP_001257822.1	trafficking protein particle complex subunit 6A isoform 4
NM_024108.3	NP_077013.1	trafficking protein particle complex subunit 6A isoform 1

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRAPPC6A 蛋白结构

TRAPP

0
100
159 a.a.

蛋白主名

其他名称

trafficking protein particle complex subunit 6A

TRAPP complex subunit 6A

TRAPPC6A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TRAPPC6A	O75865	HEL-S-101	Homo sapiens	V9HW27	Y2H Array	25416956
种属内	TRAPPC6A	O75865	HEL-S-101	Homo sapiens	V9HW27	Y2H Prey Pooling	25416956
种属内	TRAPPC6A	O75865	HEL-S-101	Homo sapiens	V9HW27	Validated Y2H	25416956
种属内	TRAPPC6A	O75865	ZMIZ2	Homo sapiens	Q8NF64-2	Y2H Array	25416956
种属内	TRAPPC6A	O75865	ZMIZ2	Homo sapiens	Q8NF64-2	Y2H Prey Pooling	25416956
种属间	TRAPPC6A	O75865	Hoxa1	Mus musculus	P09022	Pull Down	23088713
种属间	TRAPPC6A	O75865	Hoxa1	Mus musculus	P09022	Y2H	23088713
种属内	TRAPPC6A	O75865	TRAPPC3	Homo sapiens	O43617	Y2H Prey Pooling	25416956
种属内	TRAPPC6A	O75865	TRAPPC3	Homo sapiens	O43617	Pull Down	16828797
种属内	TRAPPC6A	O75865	TRAPPC3	Homo sapiens	O43617	Y2H Array	31515488
种属内	TRAPPC6A	O75865	TRAPPC3	Homo sapiens	O43617	Y2H Array	25416956
种属内	TRAPPC6A	O75865	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Spondyloepiphyseal Dysplasia Tarda, X-Linked

Spondyloepiphyseal Dysplasia Tarda	X-Linked Spondyloepiphyseal Dysplasia Tarda
SEDT	Sed Tarda, X-Linked
Spondyloepiphyseal Dysplasia, Late	Spondyloepiphyseal Dysplasia Tarda X-Linked
Sed	X Linked Spondyloepiphyseal Dysplasia Tarda
X-Linked Spondyloepiphyseal Dysplasia	Late Onset Spondyloepiphyseal Dysplasia
Sed Tarda	X-Linked Sed
X-Linked Sedt	Dysplasia, Spondyloepiphyseal, Tarda
Spondyloepiphyseal Dysplasia

Developmental And Epileptic Encephalopathy 84

DEE84	Jamuar Syndrome
Eiee84	Developmental And Epileptic Encephalopathy, 84
Epileptic Encephalopathy, Early Ifantile, 84	Early Infantile Epileptic Encephalopathy 84
Epileptic Encephalopathy, Early Infantile, 84	Encephalopathy, Epileptic, Early Infantile, Type 84

Developmental And Epileptic Encephalopathy 28

DEE28	Epileptic Encephalopathy, Early Infantile, 28
Eiee28	Developmental And Epileptic Encephalopathy, 28
Early Infantile Epileptic Encephalopathy 28	Encephalopathy, Epileptic, Early Infantile, Type 28

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14993	TRAPPC6A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	TRAPPC6A	VGNC	VGNC:36292
Felis catus	TRAPPC6A	VGNC	VGNC:66514
Macaca mulatta	TRAPPC6A	VGNC	VGNC:79374
Mus musculus	TRAPPC6A	MGD	MGI:1914341
Canis familiaris	TRAPPC6A	VGNC	VGNC:47785
Rattus norvegicus	TRAPPC6A	RGD	RGD:1591735

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