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  2. TNIP2 - TNFAIP3 interacting protein 2 Gene

TNIP2 - TNFAIP3 interacting protein 2 Gene

中文名称:TNFAIP3 相互作用蛋白 2

种属: Homo sapiens

同用名: KLIP; ABIN2; FLIP1

基因 ID: 79155 | 基因类型: protein coding

关于 TNIP2

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:2,741,648-2,756,336 (from NCBI)

This gene has 7 transcripts (splice variants), 169 orthologues and 2 paralogues. Ubiquitous expression in small intestine (RPKM 12.1), colon (RPKM 11.5) and 25 other tissues.

功能概要

该基因编码一种蛋白质,可作为 NFkappaB 激活的抑制剂。编码的蛋白质还参与特定细胞类型的 MAP/ERK 信号通路。它可能参与内皮细胞的凋亡。可变剪接导致多个转录本变体。与该基因相关的假基因位于 X 染色体上。[RefSeq 提供,2014 年 5 月]

This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in Apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014]

TNIP2 基因产物(3)

mRNA Protein Name
NM_001161527.2 NP_001154999.1 TNFAIP3-interacting protein 2 isoform 2
NM_001292016.2 NP_001278945.1 TNFAIP3-interacting protein 2 isoform 3
NM_024309.4 NP_077285.3 TNFAIP3-interacting protein 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables polyubiquitin modification-dependent protein binding IDA
IDA: 通过直接分析推断
18212736 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12595760 GOA
enables protein kinase binding IDA
IDA: 通过直接分析推断
21784860 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of endothelial cell apoptotic process IDA
IDA: 通过直接分析推断
12933576 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
21784860 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12753905 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TNIP2 蛋白结构

EABR

EABR: TSG101 and ALIX binding domain of CEP55 (214 - 246)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 429 a.a.
蛋白主名 其他名称

TNFAIP3-interacting protein 2

A20-binding inhibitor of NF-kappaB activation-2

TNIP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TNIP2 Q8NFZ5 NFKB1 Homo sapiens P19838-1 15169888
种属内
TNIP2 Q8NFZ5 NFKB1 Homo sapiens P19838-1 15169888
种属内
TNIP2 Q8NFZ5 STK11 Homo sapiens Q15831
Y2H
12753905
种属内
TNIP2 Q8NFZ5 REL Homo sapiens Q04864
TAP
14743216
种属内
TNIP2 Q8NFZ5 MAP3K8 Homo sapiens P41279 15169888
种属内
TNIP2 Q8NFZ5 MAP3K8 Homo sapiens P41279 15169888
种属内
TNIP2 Q8NFZ5 MAP3K8 Homo sapiens P41279
TAP
14743216
种属内
TNIP2 Q8NFZ5 MAP3K8 Homo sapiens P41279 15169888
种属内
TNIP2 Q8NFZ5 TNFAIP3 Homo sapiens P21580 15169888
种属内
TNIP2 Q8NFZ5 TNFAIP3 Homo sapiens P21580 30561431
种属内
TNIP2 Q8NFZ5 TNFAIP3 Homo sapiens P21580 11389905
种属内
TNIP2 Q8NFZ5 IKBKG Homo sapiens Q9Y6K9 14653779
种属内
TNIP2 Q8NFZ5 IKBKG Homo sapiens Q9Y6K9 30561431
种属内
TNIP2 Q8NFZ5 IKBKG Homo sapiens Q9Y6K9
Y2H
21988832
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Rabies

Lyssa

Hydrophobia

St Hubert Disease

Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TNIP2 VGNC VGNC:79182
Bos taurus TNIP2 VGNC VGNC:54503
Mus musculus TNIP2 MGD MGI:2386643
Felis catus TNIP2 VGNC VGNC:66417
Rattus norvegicus TNIP2 RGD RGD:1307717
Canis familiaris TNIP2 VGNC VGNC:47677