1. Gene
  2. NETO1 - neuropilin and tolloid like 1 Gene

NETO1 - neuropilin and tolloid like 1 Gene

中文名称:neuropilin 和 tolloid 样 1

种属: Homo sapiens

同用名: BCTL1; BTCL1

基因 ID: 81832 | 基因类型: protein coding

关于 NETO1

Cytogenetic location: 18q22.3 Genomic coordinates (GRCh38): 18:72,742,314-72,867,987 (from NCBI)

This gene has 7 transcripts (splice variants), 268 orthologues and 35 paralogues. Biased expression in brain (RPKM 5.4) and spleen (RPKM 0.5).

功能概要

该基因编码的跨膜蛋白包含两个细胞外 CUB 结构域,后跟一个低密度脂蛋白 A 类 (LDLa) 结构域。这种蛋白质被认为通过调节海马中突触 N-甲基-D-天冬氨酸受体复合物的功能,在空间学习和记忆中发挥关键作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供,2017 年 8 月]

This gene encodes a transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. This protein is thought to play a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2017]

NETO1 基因产物(8)

mRNA Protein Name
NM_001201465.3 NP_001188394.2 neuropilin and tolloid-like protein 1 isoform 3 precursor
NM_001354017.2 NP_001340946.2 neuropilin and tolloid-like protein 1 isoform 3 precursor
NM_001354018.2 NP_001340947.2 neuropilin and tolloid-like protein 1 isoform 4
NM_001354020.2 NP_001340949.2 neuropilin and tolloid-like protein 1 isoform 5
NM_001354021.2 NP_001340950.1 neuropilin and tolloid-like protein 1 isoform 6 precursor
NM_001354022.2 NP_001340951.1 neuropilin and tolloid-like protein 1 isoform 7
NM_138966.5 NP_620416.2 neuropilin and tolloid-like protein 1 isoform 3 precursor
NM_138999.2 NP_620552.1 neuropilin and tolloid-like protein 1 isoform 1 precursor

NETO1 蛋白结构

CUB

CUB: CUB domain (41 - 152)

CUB

CUB: CUB domain (193 - 283)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (291 - 326)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 533 a.a.
蛋白主名 其他名称

neuropilin and tolloid-like protein 1

brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1

重组 NETO1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75937 NETO1 Protein, Human (HEK293, His) Q8TDF5-3 (T23-T344) ≥95%

关联疾病

疾病名称 别名
Liver Inflammatory Pseudotumor

Inflammatory Pseudotumor Of The Liver

Liver Inflammatory Myofibroblastic Tumor

Hypermobility Of Coccyx

Coccygeal Hypermobility Syndrome

Hypermobility Of The Coccyx

Developmental And Epileptic Encephalopathy 76

DEE76

Epileptic Encephalopathy, Early Infantile, 76

Eiee76

Decam

Developmental And Epileptic Encephalopathy, 76

Developmental Delay, Epileptic Encephalopathy, Cerebral Atrophy, And Abnormal Myelination

Developmental Delay, Epileptic Endephalopathy, Cerebral Atrophy, And Abnormal Myelination

Early Infantile Epileptic Encephalopathy 76

Klippel-Feil Syndrome 3
Cataract 4, Multiple Types

Cataract 4 Multiple Types

CTRCT4

Cca3

Pcc

Aculeiform Cataract

Cataract 4, Multiple Types, With Or Without Microcornea

Cataract, Crystalline Aculeiform

Caca

Cataract, Congenital, Cerulean Type, 3

Congenital Cataract Cerulean Type 3

Cataract Congenital Dominant Non Nuclear

Ccp

Cataract, Nonnuclear Polymorphic Congenital

Cataract, Punctate, Progressive Juvenile-Onset

Cataract 4 Multiple Types With Or Without Microcornea

Autosomal Dominant Nonnuclear Polymorphic Congenital Cataract

Cataract, Polymorphic Congenital

Congenital Cataract Blue Dot Type 3

Congenital Non-Nuclear Polymorphic Cataract

Crystalline Aculeiform Cataract

Punctate, Progressive Juvenile-Onset, Cataract

Cataract, Nonnuclear Polymorphic Congenital, Autosomal Dominant

Superior Mesenteric Artery Syndrome

Wilkie Syndrome

Wilkie'S Syndrome

Arteriomesenteric Duodenal Compression Syndrome

Cast Syndrome

Vascular Compression Of The Duodenum

Smas

Arteriomesenteric Compression Of Duodenojejunal Flexure

Kummell'S Disease

Traumatic Spondylopathy

Kummell Disease

Kummell'S Spondylitis

Kümmelll-Verneuil Disease

Kümmell Spondylitis

Kümmell Disease

Traumatic Spondylosis

Breast Angiosarcoma

Angiosarcoma Of The Breast

Hemangiosarcoma Of The Breast

Primary Angiosarcoma Of Breast

Brown-Sequard Syndrome

Brown-Squard Syndrome

Hemicord Syndrome

Hemiparaplegic Syndrome

Hemispinal Cord Syndrome

Brown-Séquard Syndrome

Cleft Soft Palate

Cleft Velum

Cleft Velum Palatinum

Soft Cleft Palate

Soft Palate Perforation

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris NETO1 VGNC VGNC:43748
Bos taurus NETO1 VGNC VGNC:32011
Felis catus NETO1 VGNC VGNC:63780
Macaca mulatta NETO1 VGNC VGNC:75172
Mus musculus NETO1 MGD MGI:2180216
Rattus norvegicus NETO1 RGD RGD:1566269
Others NETO1 NCBI