2. Gene
  3. Ghsr - growth hormone secretagogue receptor Gene

Ghsr - growth hormone secretagogue receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：生长激素促分泌素受体

种属: Rattus norvegicus

基因 ID: 84022 | 基因类型: protein coding

关于 Ghsr

Primary_assembly 2: 110,268,489-110,271,865 forward strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 218 orthologues, 14 paralogues and is associated with 34 phenotypes. Biased expression in Testes (RPKM 7.) and Brain (RPKM 3.).

功能概要

该基因编码的蛋白可启动生长激素促分泌素受体活性和肽激素结合活性。参与多个过程，包括调节消化系统过程；细胞分泌调节；和对肽激素的反应。在胰岛素分泌的负调节上游或负调节内起作用。位于质膜。活跃于 Schaffer 侧支 - CA1 突触和谷氨酸能突触。是突触膜的组成部分。用于研究大脑中动脉梗塞。孤立性生长激素缺乏症的生物标志物；多发性内分泌肿瘤；阻塞性睡眠呼吸暂停;癫痫持续状态；和短暂性脑缺血。该基因的人类直系同源物与肥胖有关。与人类 GHSR（生长激素促分泌素受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables growth hormone secretagogue receptor activity and peptide hormone binding activity. Involved in several processes, including regulation of digestive system process; regulation of secretion by cell; and response to peptide hormone. Acts upstream of or within negative regulation of Insulin secretion. Located in plasma membrane. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is integral component of synaptic membrane. Used to study middle cerebral artery infarction. Biomarker of isolated growth hormone deficiency; multiple endocrine neoplasia; obstructive sleep apnea; status epilepticus; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in obesity. Orthologous to human GHSR (growth hormone secretagogue receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ghsr 基因产物(1)

mRNA Protein Name
NM_032075.3 NP_114464.1 growth hormone secretagogue receptor type 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables growth hormone secretagogue receptor activity IDA
IDA: 通过直接分析推断
9092793 RGD
enables growth hormone secretagogue receptor activity IMP
IMP: 通过突变表型推断
17109695 RGD
enables hormone binding IPI
IPI: 通过物理相互作用推断
10604470 RGD
enables peptide hormone binding IMP
IMP: 通过突变表型推断
17109695 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
10604470 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
9092793 RGD
involved in cellular response to insulin-like growth factor stimulus IEP
IEP: 通过表达模式推断
15680488 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: 通过表达模式推断
15155262 RGD
involved in cellular response to thyroid hormone stimulus IEP
IEP: 通过表达模式推断
11207942 RGD
involved in female pregnancy IEP
IEP: 通过表达模式推断
20814072 RGD
involved in ghrelin secretion IMP
IMP: 通过突变表型推断
21778696 RGD
involved in learning or memory IDA
IDA: 通过直接分析推断
19652956 RGD
involved in negative regulation of appetite IMP
IMP: 通过突变表型推断
21778696 RGD
acts upstream of or within negative regulation of insulin secretion IDA
IDA: 通过直接分析推断
17130496 RGD
involved in negative regulation of locomotion involved in locomotory behavior IMP
IMP: 通过突变表型推断
19931319 RGD
involved in negative regulation of macrophage apoptotic process IMP
IMP: 通过突变表型推断
25337654 RGD
involved in negative regulation of norepinephrine secretion IMP
IMP: 通过突变表型推断
17911350 RGD
involved in negative regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
17911350 RGD
involved in positive regulation of eating behavior IMP
IMP: 通过突变表型推断
26512025 RGD
involved in positive regulation of fatty acid metabolic process IMP
IMP: 通过突变表型推断
12045256 RGD
involved in positive regulation of growth IMP
IMP: 通过突变表型推断
12045256 RGD
involved in positive regulation of small intestinal transit IMP
IMP: 通过突变表型推断
15890336 RGD
involved in positive regulation of small intestine smooth muscle contraction IMP
IMP: 通过突变表型推断
15890336 RGD
involved in positive regulation of sprouting angiogenesis IMP
IMP: 通过突变表型推断
21642627 RGD
involved in positive regulation of vascular endothelial cell proliferation IMP
IMP: 通过突变表型推断
21642627 RGD
involved in postsynaptic modulation of chemical synaptic transmission EXP
EXP: 通过实验结果推断
26153524 RGD
involved in postsynaptic modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
26153524 RGD
involved in regulation of feeding behavior IMP
IMP: 通过突变表型推断
12045256 RGD
involved in regulation of gastric motility IMP
IMP: 通过突变表型推断
23525979 RGD
involved in regulation of growth hormone secretion IMP
IMP: 通过突变表型推断
12045256 RGD
involved in regulation of hindgut contraction IMP
IMP: 通过突变表型推断
16873401 RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane EXP
EXP: 通过实验结果推断
24367106 RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: 通过直接分析推断
24367106 RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IEP
IEP: 通过表达模式推断
24367106 RGD
involved in regulation of postsynapse organization EXP
EXP: 通过实验结果推断
22516464 RGD
involved in regulation of postsynapse organization IDA
IDA: 通过直接分析推断
22516464 RGD
involved in regulation of transmission of nerve impulse IMP
IMP: 通过突变表型推断
23525979 RGD
involved in response to L-glutamate IEP
IEP: 通过表达模式推断
10718930 RGD
involved in response to dexamethasone IEP
IEP: 通过表达模式推断
10844575 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
24473434 RGD
involved in response to follicle-stimulating hormone IEP
IEP: 通过表达模式推断
12606422 RGD
involved in response to growth hormone IEP
IEP: 通过表达模式推断
9822798 RGD
involved in spermatogenesis IEP
IEP: 通过表达模式推断
12606422 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse EXP
EXP: 通过实验结果推断
26153524 RGD
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
26153524 RGD
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
22516464 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
22516464 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
24367106 RGD
is active in synaptic membrane IDA
IDA: 通过直接分析推断
24367106 RGD
is active in synaptic membrane IMP
IMP: 通过突变表型推断
24367106 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Ghsr 蛋白结构

7tmA_GHSR

7tmA_GHSR: cd15131 (43 - 331)

7tmA_GHSR

7tmA_GHSR: cd15131 (43 - 69)

7tmA_GHSR

7tmA_GHSR: cd15131 (76 - 101)

7tmA_GHSR

7tmA_GHSR: cd15131 (114 - 144)

7tmA_GHSR

7tmA_GHSR: cd15131 (156 - 178)

7tmA_GHSR

7tmA_GHSR: cd15131 (207 - 236)

7tmA_GHSR

7tmA_GHSR: cd15131 (253 - 283)

7tmA_GHSR

7tmA_GHSR: cd15131 (299 - 324)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
蛋白主名 其他名称

growth hormone secretagogue receptor type 1

GH-releasing peptide receptor

GHRP

GHS-R

ghrelin receptor

相关产品

Approval
生物活性分子 (5)
目录号 产品名 作用方式
纯度 是否罕见病
HY-14734 Anamorelin Agonist 99.64% 否
HY-14734A Anamorelin hydrochloride Agonist 99.97% 否
HY-14820A Macimorelin acetate Agonist 98.96% 是
HY-14820 Macimorelin Agonist / 否
HY-14734B Anamorelin Fumarate Agonist / 否
Clinical Phase
生物活性分子 (6)
目录号 产品名 作用方式
纯度 Phase
HY-19884B Relamorelin TFA Agonist 99.89% Phase 3
HY-14903 Ulimorelin Agonist 96.10% Phase 3
HY-19884 Relamorelin Agonist / Phase 3
HY-19884A Relamorelin acetate Agonist / Phase 3
HY-50844 Ibutamoren Mesylate Agonist 99.86% Phase 2
HY-P0231 AZP-531 98.54% Phase 1
Pre-clinical Phase
生物活性分子 (47)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-103007 TC-G-1008 Agonist 99.61% 否
HY-12584 PF-5190457 Inhibitor 98.34% 否
HY-108699 TM-N1324 Agonist 99.91% 否
HY-U00433 JMV 2959 Antagonist 99.91% 否
HY-13964A YIL781 hydrochloride Antagonist 99.48% 否
HY-P1366 des-​Gln14-​Ghrelin 98.61% 否
HY-P3304 MR 409 Agonist 99.51% 否
HY-P0089A Human growth hormone-releasing factor TFA 99.66% 否
HY-10957 L-692429 Agonist 99.90% 否
HY-U00433A JMV 2959 hydrochloride Antagonist 98.09% 否
HY-15243 Capromorelin Tartrate Agonist 98.19% 否
HY-50760 L-692585 Agonist 99.32% 否
HY-13964 YIL781 Antagonist 99.68% 否
HY-P4750 Acetyl-(D-Arg2)-GRF (1-29) amide (human) Antagonist 99.67% 否
HY-P3397A JV-1-36 acetate Antagonist 99.27% 否
HY-P0089 Human growth hormone-releasing factor / 否
HY-P3594 [His1,Nle27] GHRF (1-32), amide, human / 否
HY-113906A (αR,8aS)-GSK1614343 Antagonist 99.40% 否
HY-P1306 Obestatin(rat) 98.73% 否
HY-14495B BMS-604992 dihydrochloride Agonist / 否
HY-116625 PF-04628935 Antagonist / 否
HY-115272 GSK894490A Agonist / 否
HY-157556 BPP-2 / 否
HY-P3595 GHRF, porcine / 否
HY-P3397 JV-1-36 Antagonist / 否
HY-145364 Ghrelin receptor full agonist-2 Agonist / 否
HY-P1306A Obestatin(rat) TFA / 否
HY-P1366A des-​Gln14-​Ghrelin TFA / 否
HY-P3607 GHRF, bovine Activator / 否
HY-P1432 K-(D-1-Nal)-FwLL-NH2 Antagonist / 否
HY-113906 GSK1614343 Antagonist / 否
HY-P10283 S1H Antagonist / 否
HY-117584 L-163255 free base / 否
HY-153095A PF-6870961 hydrochloride Agonist / 否
HY-P1139 Cortistatin-8 Antagonist / 否
HY-153095 PF-6870961 Agonist / 否
HY-14495 BMS-604992 Agonist / 否
HY-15242 Capromorelin Activator / 否
HY-137061 AZ-GHS-22 Antagonist / 否
HY-14495A BMS-604992 free base Agonist / 否
HY-P1432A K-(D-1-Nal)-FwLL-NH2 TFA Antagonist / 否
HY-10199A Ibutamoren Agonist / 否
HY-N12348 Emoghrelin Activator / 否
HY-111232 GSK894281 Agonist / 否
HY-10957A L-692429 hydrochloride Agonist / 否
HY-P10673 KwFwLL-NH2 Antagonist / 否
HY-116959 SM-130686 / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ghsr NCBI NCBI:2693
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