2. GPCR/G Protein Neuronal Signaling
  3. GHSR Adrenergic Receptor
  4. Ulimorelin

Ulimorelin  (Synonyms: TZP-101)

目录号: HY-14903
产品使用指南

摩尔计算器

Ulimorelin (TZP-101) 是生长素释放肽受体 (GRLN) 激动剂，EC50 为 29 nM，Ki 为 16 nM。Ulimorelin 是一种促运动剂，通过竞争性拮抗 α1-肾上腺素受体引起血管舒张。Ulimorelin 可以刺激肠蠕动，可用于营养不良。

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Ulimorelin Chemical Structure

Ulimorelin Chemical Structure

CAS No. : 842131-33-3

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Ulimorelin 相关抗体

Top Publications Citing Use of Products

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GHSR1a

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ulimorelin (TZP-101) is a ghrelin receptor (GRLN) agonist with an EC50 of 29 nM and a Ki of 16 nM. Ulimorelin is a prokinetic agent and causes vasorelaxation through competitive antagonist action at α1-adrenoceptors. Ulimorelin stimulates intestinal motility and is used for malnutrition[1][2][3].

体内研究
(In Vivo)

Ulimorelin (TZP-101; 0.3-5 mg/kg; i.v.) causes a dose dependent increase in the numbers and amplitudes of phasic pressure waves recorded from the colorectum[1].
Ulimorelin (1, 3, 5 mg/kg; i.v.) causes a substantial and prolonged (~1 h) increase in colorectal propulsive activity and expulsion of colonic contents[1].
Ulimorelin (p.o.; 8 mg/kg) has a Cmax of 0.39 μM and a AUC of 82 μM•min for rats. Ulimorelin (i.v.; 2 mg/kg) has a T1/2 of 50 mins, a CL of 24 mL/min/kg, and a Vss of 1.7 L/kg for rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 0.3, 1, 3, 5 mg/kg
Administration: i.v.
Result: Caused a dose dependent increase in the numbers and amplitudes of phasic pressure waves recorded from the colorectum.
Clinical Trial
分子量

538.65

Formula

C30H39FN4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ulimorelin 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ulimorelin842131-33-3TZP-101TZP101TZP 101GHSRAdrenergic ReceptorGrowth hormone secretagogue receptorGhrelin receptorBeta ReceptorGhrelinreceptorprokineticvasorelaxationα1-adrenoceptorsintestinalmotilitymalnutritionInhibitorinhibitorinhibit

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