1. Gene
  2. WDR54 - WD repeat domain 54 Gene

WDR54 - WD repeat domain 54 Gene

中文名称:WD 重复域 54

种属: Homo sapiens

基因 ID: 84058 | 基因类型: protein coding

关于 WDR54

This gene has 12 transcripts (splice variants), 201 orthologues and 14 paralogues. Broad expression in testis (RPKM 18.8), lung (RPKM 6.6) and 23 other tissues.

功能概要

启用蛋白质同源二聚化活性。参与受体内化的负调节;调节 MAPK 级联;表皮生长因子受体信号通路的调控。位于囊泡内。 [由基因组资源联盟提供,2022 年 4 月]

Enables protein homodimerization activity. Involved in negative regulation of receptor internalization; regulation of MAPK cascade; and regulation of epidermal growth factor receptor signaling pathway. Located in vesicle. [provided by Alliance of Genome Resources, Apr 2022]

WDR54 基因产物(4)

mRNA Protein Name
NM_001320823.2 NP_001307752.1 WD repeat-containing protein 54 isoform a
NM_001320824.2 NP_001307753.1 WD repeat-containing protein 54 isoform b
NM_001320825.2 NP_001307754.1 WD repeat-containing protein 54 isoform c
NM_032118.4 NP_115494.1 WD repeat-containing protein 54 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
30458214 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of receptor internalization IMP
IMP: 通过突变表型推断
30458214 GOA
involved in regulation of MAPK cascade IMP
IMP: 通过突变表型推断
30458214 GOA
involved in regulation of epidermal growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
30458214 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in vesicle IDA
IDA: 通过直接分析推断
30458214 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

WDR54 蛋白结构

WD40

WD40: WD domain, G-beta repeat (247 - 280)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
蛋白主名 其他名称

WD repeat-containing protein 54

直系同源

种属 基因名 来源 基因 ID
Bos taurus WDR54 VGNC VGNC:36905
Rattus norvegicus WDR54 RGD RGD:1561494
Macaca mulatta WDR54 VGNC VGNC:79541
Canis familiaris WDR54 VGNC VGNC:48375
Mus musculus WDR54 MGD MGI:1922909
Felis catus WDR54 VGNC VGNC:67040