1. Gene
  2. HVCN1 - hydrogen voltage gated channel 1 Gene

HVCN1 - hydrogen voltage gated channel 1 Gene

中文名称:氢电压门控通道 1

种属: Homo sapiens

同用名: HV1; VSOP

基因 ID: 84329 | 基因类型: protein coding

关于 HVCN1

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:110,648,686-110,704,952 (from NCBI)

This gene has 9 transcripts (splice variants), 200 orthologues and 6 paralogues. Broad expression in lymph node (RPKM 18.5), testis (RPKM 16.2) and 21 other tissues.

功能概要

该基因编码一种在免疫系统的某些细胞中表达更高的电压门控蛋白通道蛋白。吞噬细胞产生需要这种通道蛋白的超氧阴离子,而在 B 细胞中,同样的过程促进了抗体的产生。然而,同样的通道蛋白也可以调节其他细胞 (包括精子) 的功能。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供,2012 年 1 月]

This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in Other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

HVCN1 基因产物(3)

mRNA Protein Name
NM_001040107.2 NP_001035196.1 voltage-gated hydrogen channel 1 isoform 1
NM_001256413.2 NP_001243342.1 voltage-gated hydrogen channel 1 isoform 2
NM_032369.4 NP_115745.2 voltage-gated hydrogen channel 1 isoform 1

HVCN1 蛋白结构

Ion_trans

Ion_trans: Ion transport protein (141 - 216)

  • 0
  • 100
  • 200
  • 273 a.a.
蛋白主名 其他名称

voltage-gated hydrogen channel 1

voltage sensor domain-only protein

HVCN1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HVCN1 Q96D96 MUCL1 Homo sapiens Q96DR8 28514442
种属内
HVCN1 Q96D96 KLHDC10 Homo sapiens Q6PID8 33961781
种属内
HVCN1 Q96D96 JCHAIN Homo sapiens P01591 28514442
种属内
HVCN1 Q96D96 STXBP1 Homo sapiens P61764 33961781
种属内
HVCN1 Q96D96 NECTIN2 Homo sapiens Q92692 33961781
种属内
HVCN1 Q96D96 DOK2 Homo sapiens O60496 28514442
种属内
HVCN1 Q96D96 LMNA Homo sapiens P02545 33961781
种属内
HVCN1 Q96D96 GSDME Homo sapiens O60443 33961781
种属内
HVCN1 Q96D96 STXBP2 Homo sapiens Q15833 33961781
种属内
HVCN1 Q96D96 ASAH1 Homo sapiens Q13510 33961781
种属内
HVCN1 Q96D96 HVCN1 Homo sapiens Q96D96 18509058
种属内
HVCN1 Q96D96 FAM91A1 Homo sapiens Q658Y4 33961781
种属内
HVCN1 Q96D96 PYCR3 Homo sapiens Q53H96 33961781
种属内
HVCN1 Q96D96 CD63 Homo sapiens P08962 33961781
种属内
HVCN1 Q96D96 CST1 Homo sapiens P01037 28514442
种属内
HVCN1 Q96D96 KIF5B Homo sapiens P33176 33961781
种属内
HVCN1 Q96D96 HVCN1 Homo sapiens Q96D96 18509058
种属内
HVCN1 Q96D96 KLC4 Homo sapiens Q9NSK0 33961781
种属内
HVCN1 Q96D96 FUS Homo sapiens P35637 30021884
种属内
HVCN1 Q96D96 KIF5C Homo sapiens O60282 33961781
种属内
HVCN1 Q96D96 CHEK1 Homo sapiens O14757 33961781
种属内
HVCN1 Q96D96 PIGR Homo sapiens P01833 28514442
种属内
HVCN1 Q96D96 TANK Homo sapiens Q92844 33961781
种属内
HVCN1 Q96D96 OXLD1 Homo sapiens Q5BKU9 28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hydrolethalus Syndrome 2

HLS2

Hydrolethalus Syndrome, Type 2

Alzheimer Disease 17

AD17

Alzheimer'S Disease 17

Alzheimer Disease 17, Late-Onset

Alzheimer Disease 17, Late Onset

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus HVCN1 RGD RGD:1310788
Bos taurus HVCN1 VGNC VGNC:30010
Felis catus HVCN1 VGNC VGNC:62860
Mus musculus HVCN1 MGD MGI:1921346
Canis familiaris HVCN1 VGNC VGNC:41842
Macaca mulatta HVCN1 VGNC VGNC:73449