Dnmt1 - DNA methyltransferase 1 Gene

中文名称：DNA 甲基转移酶1

种属: Rattus norvegicus

关于 Dnmt1

功能概要

该基因编码的蛋白可启动多种功能，包括 DNA (cytosine-5-)-methyltransferase 活性；雌激素受体结合活性；和组蛋白脱乙酰酶结合活性。参与多个过程，包括DNA代谢过程；细胞对生长因子刺激的反应；和神经系统发育。位于细胞质中；神经细胞体；和核。部分含蛋白质复合物。用于研究胆碱缺乏症和肺癌。胆碱缺乏病的生物标志物；先天性心脏病；充血性心力衰竭;肝病（多发性）；和 2 型糖尿病。该基因的人类直系同源物与格雷夫斯病有关；常染色体显性遗传性小脑性共济失调、耳聋和发作性睡病；遗传性感觉神经病； 1E 型遗传性感觉神经病；和肺非小细胞癌。与人类 DNMT1（DNA 甲基转移酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including DNA (cytosine-5-)-methyltransferase activity; Estrogen Receptor binding activity; and histone deacetylase binding activity. Involved in several processes, including DNA metabolic process; cellular response to growth factor stimulus; and nervous system development. Located in cytoplasm; neuronal cell body; and nucleus. Part of protein-containing complex. Used to study choline deficiency disease and lung carcinoma. Biomarker of choline deficiency disease; congenital heart disease; congestive heart failure; liver disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Graves' disease; autosomal dominant cerebellar ataxia, deafness and narcolepsy; hereditary sensory neuropathy; hereditary sensory neuropathy type 1E; and lung non-small cell carcinoma. Orthologous to human DNMT1 (DNA Methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]