2. Epigenetics
  3. DNA Methyltransferase
  4. 5-Aza-4'-thio-2'-deoxycytidine

5-Aza-4'-thio-2'-deoxycytidine  (Synonyms: 5-Aza-T-dCyd; NTX-301)

目录号: HY-139015 纯度: 99.09%
COA 产品使用指南

摩尔计算器

5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd) 是一种口服有效的 DNA 甲基转移酶 I (DNMT1) 抑制剂。5-Aza-4'-thio-2'-deoxycytidine 是一种含硫脱氧胞苷类似物，具有 DNA 低甲基化的潜力。5-Aza-4'-thio-2'-deoxycytidine 具有抗肿瘤作用。

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5-Aza-4'-thio-2'-deoxycytidine Chemical Structure

5-Aza-4'-thio-2'-deoxycytidine Chemical Structure

CAS No. : 169514-76-5

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5-Aza-4'-thio-2'-deoxycytidine 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd) is an orally active DNA methyltransferase I (DNMT1) inhibitor. 5-Aza-4'-thio-2'-deoxycytidine, a sulfur-containing deoxy-cytidine analog, has the potential for DNA hypomethylating and has antitumor effects[1].

IC50 & Target[1]

DNMT1

 

体外研究
(In Vitro)

5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd; 72 h) inhibits leukemia lines: CCRF-CEM (IC50=0.2 μM), KG1a (IC50=0.06 μM). 5-Aza-4'-thio-2'-deoxycytidine also decreases viability in the NCI-H23 lung carcinoma (IC50=4.5 μM), HCT-116 colon carcinoma (IC50=58 μM) and IGROV-1 ovarian carcinoma (IC50=36 μM)[1].
5-Aza-4'-thio-2'-deoxycytidine (0.1-20 μM; 96 h) markedly depletes DNMT1 in NCI-H23 lung, HCT-116 colon and IGROV-1 ovarian cells. 5-Aza-4'-thio-2'-deoxycytidine (0.1, 0.5, 1 μM; 96 h) results in marked depletion of DNMT1 in CCRF-CEM and KG1a myeloid leukemia cells[1].
5-Aza-4'-thio-2'-deoxycytidine (1 μM; 96 h) induce CpG demethylation and re-expression of the p15 tumor suppressor gene[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

5-Aza-4'-thio-2'-deoxycytidine 相关抗体:

Western Blot Analysis[1]

Cell Line: NCI-H23 lung, HCT-116 colon and IGROV-1 ovarian cells
Concentration: 1, 5, 10, 20 μM
Incubation Time: 96 h
Result: Markedly depleted DNMT1 in cells.
体内研究
(In Vivo)

5-Aza-4'-thio-2'-deoxycytidine (6.7, 10 mg/kg/day; IP; for 9 days) is effective against NCI-H23 tumor xenografts[1].
5-Aza-4'-thio-2'-deoxycytidine (5 mg/kg/day; IP; for 9 days) decreases DNMT1 levels in tumors of CCRF-CEM tumors mice xenografts[1].
5-Aza-4'-thio-2'-deoxycytidine (1.5 mg/kg; ip; QD×5 rest and repeat 3 cycles) provides modest suppression of tumor growth as well in the HCT116 colon carcinoma, OVCAR3 ovarian tumor xenograft model. 5-Aza-4'-thio-2'-deoxycytidine has minimal antitumor effect in the HL-60 leukemia xenografts[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Young female athymic nu/nu mice with NCI-H23 tumor fragment[1]
Dosage: 6.7 or 10 mg/kg
Administration: IP; daily for 9 days
Result: Had antitumor efficacy against NCI-H23 tumor xenografts.
分子量

244.27

Formula

C8H12N4O3S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 25 mg/mL (102.35 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.0938 mL 20.4692 mL 40.9383 mL
5 mM 0.8188 mL 4.0938 mL 8.1877 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

5-Aza-4'-thio-2'-deoxycytidine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0938 mL 20.4692 mL 40.9383 mL 102.3458 mL
5 mM 0.8188 mL 4.0938 mL 8.1877 mL 20.4692 mL
10 mM 0.4094 mL 2.0469 mL 4.0938 mL 10.2346 mL
15 mM 0.2729 mL 1.3646 mL 2.7292 mL 6.8231 mL
20 mM 0.2047 mL 1.0235 mL 2.0469 mL 5.1173 mL
25 mM 0.1638 mL 0.8188 mL 1.6375 mL 4.0938 mL
30 mM 0.1365 mL 0.6823 mL 1.3646 mL 3.4115 mL
40 mM 0.1023 mL 0.5117 mL 1.0235 mL 2.5586 mL
50 mM 0.0819 mL 0.4094 mL 0.8188 mL 2.0469 mL
60 mM 0.0682 mL 0.3412 mL 0.6823 mL 1.7058 mL
80 mM 0.0512 mL 0.2559 mL 0.5117 mL 1.2793 mL
100 mM 0.0409 mL 0.2047 mL 0.4094 mL 1.0235 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Aza-4'-thio-2'-deoxycytidine169514-76-55-Aza-T-dCyd NTX-301NTX301NTX 301NTX-301DNA MethyltransferaseDNMTsDNA MTasesorallyhypomethylatingleukemiaCCRF-CEMKG1aNCI-H23HCT-116IGROV-1Inhibitorinhibitorinhibit

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