2. Gene
  3. AFAP1L2 - actin filament associated protein 1 like 2 Gene

AFAP1L2 - actin filament associated protein 1 like 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肌动蛋白丝相关蛋白 1 like 2

种属: Homo sapiens

同用名: XB130; KIAA1914; CTB-1144G6.4

基因 ID: 84632 | 基因类型: protein coding

关于 AFAP1L2

Cytogenetic location: 10q25.3 Genomic coordinates (GRCh38): 10:114,280,725-114,405,175 (from NCBI)

This gene has 7 transcripts (splice variants), 194 orthologues and 2 paralogues. Broad expression in thyroid (RPKM 34.2), spleen (RPKM 23.9) and 15 other tissues.

功能概要

启用 SH2 域绑定活动； SH3 域绑定活动；和蛋白酪氨酸激酶激活剂活性。参与多个过程，包括表皮生长因子受体信号通路的正调控；基因表达的调节；和有丝分裂细胞周期的调节。位于胞质溶胶和质膜中。 [由基因组资源联盟提供，2022 年 4 月]

Enables SH2 domain binding activity; SH3 domain binding activity; and protein tyrosine kinase activator activity. Involved in several processes, including positive regulation of epidermal growth factor receptor signaling pathway; regulation of gene expression; and regulation of mitotic cell cycle. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

AFAP1L2 基因产物(20)

mRNA Protein Name
NM_001001936.3 NP_001001936.1 actin filament-associated protein 1-like 2 isoform 1
NM_001287824.2 NP_001274753.1 actin filament-associated protein 1-like 2 isoform 3
NM_001351064.2 NP_001337993.1 actin filament-associated protein 1-like 2 isoform 4
NM_001351065.2 NP_001337994.1 actin filament-associated protein 1-like 2 isoform 5
NM_001351066.2 NP_001337995.1 actin filament-associated protein 1-like 2 isoform 6
NM_001351067.2 NP_001337996.1 actin filament-associated protein 1-like 2 isoform 7
NM_001351068.2 NP_001337997.1 actin filament-associated protein 1-like 2 isoform 8
NM_001351069.2 NP_001337998.1 actin filament-associated protein 1-like 2 isoform 9
NM_001351070.2 NP_001337999.1 actin filament-associated protein 1-like 2 isoform 10
NM_001351071.2 NP_001338000.1 actin filament-associated protein 1-like 2 isoform 11
NM_001351072.2 NP_001338001.1 actin filament-associated protein 1-like 2 isoform 12
NM_001351073.2 NP_001338002.1 actin filament-associated protein 1-like 2 isoform 13
NM_001351074.2 NP_001338003.1 actin filament-associated protein 1-like 2 isoform 14
NM_001351075.2 NP_001338004.1 actin filament-associated protein 1-like 2 isoform 15
NM_001351076.2 NP_001338005.1 actin filament-associated protein 1-like 2 isoform 16
NM_001351077.2 NP_001338006.1 actin filament-associated protein 1-like 2 isoform 17
NM_001351078.2 NP_001338007.1 actin filament-associated protein 1-like 2 isoform 18
NM_001351079.2 NP_001338008.1 actin filament-associated protein 1-like 2 isoform 19
NM_001351080.2 NP_001338009.1 actin filament-associated protein 1-like 2 isoform 20
NM_032550.4 NP_115939.1 actin filament-associated protein 1-like 2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SH2 domain binding IPI
IPI: 通过物理相互作用推断
17412687 GOA
enables SH3 domain binding IPI
IPI: 通过物理相互作用推断
17412687 GOA
enables protein tyrosine kinase activator activity IDA
IDA: 通过直接分析推断
17412687 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in inflammatory response IDA
IDA: 通过直接分析推断
17412687 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
17412687 GOA
involved in positive regulation of epidermal growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
17412687 GOA
involved in positive regulation of interleukin-8 production IDA
IDA: 通过直接分析推断
17412687 GOA
involved in regulation of interleukin-6 production IDA
IDA: 通过直接分析推断
17412687 GOA
involved in regulation of mitotic cell cycle IDA
IDA: 通过直接分析推断
17412687 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
17412687 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AFAP1L2 蛋白结构

PH

PH: PH domain (181 - 269)

PH

PH: PH domain (365 - 439)

  • 0
  • 200
  • 400
  • 600
  • 818 a.a.
蛋白主名 其他名称

actin filament-associated protein 1-like 2

AFAP1-like protein 2

关联疾病

疾病名称 别名
Vesicoureteral Reflux

Vesico-Ureteral Reflux
Cartilage Cancer

Chondrogenic Neoplasm
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00426 AFAP1L2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus AFAP1L2 RGD RGD:1310668
Felis catus AFAP1L2 VGNC VGNC:59667
Bos taurus AFAP1L2 VGNC VGNC:25708
Canis familiaris AFAP1L2 VGNC VGNC:49824
Mus musculus AFAP1L2 MGD MGI:2147658
Macaca mulatta AFAP1L2 VGNC VGNC:69700
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