2. Gene
  3. Prkd1 - protein kinase D1 Gene

Prkd1 - protein kinase D1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：蛋白激酶 D1

种属: Rattus norvegicus

同用名: Pkcm; Prkcm; nPKC-D1; nPKC-mu

基因 ID: 85421 | 基因类型: protein coding

关于 Prkd1

Primary_assembly 6: 67,725,905-68,039,042 reverse strand.mRatBN7.2:CM026979.1

This gene has 3 transcripts (splice variants), 208 orthologues, 2 paralogues and is associated with 8 phenotypes. Biased expression in Kidney (RPKM 52.3), Heart (RPKM 33.2) and 8 other tissues.

功能概要

该基因编码的蛋白可启动蛋白质丝氨酸/苏氨酸激酶活性。参与细胞内信号转导。预计位于多种细胞成分中，包括自噬体膜；细胞-细胞连接；和跨高尔基网络。与人类 PRKD1（蛋白激酶 D1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein serine/threonine kinase activity. Involved in intracellular signal transduction. Predicted to be located in several cellular components, including autophagosome membrane; cell-cell junction; and trans-Golgi network. Orthologous to human PRKD1 (protein kinase D1). [provided by Alliance of Genome Resources, Apr 2022]

Prkd1 基因产物(2)

mRNA Protein Name
NM_001412095.1 NP_001399024.1 serine/threonine-protein kinase D1 isoform 2
NM_001276715.2 NP_001263644.1 serine/threonine-protein kinase D1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables heat shock protein binding IPI
IPI: 通过物理相互作用推断
25889640 RGD
enables protein kinase C binding IPI
IPI: 通过物理相互作用推断
15652511 RGD
enables protein kinase activity IDA
IDA: 通过直接分析推断
16648482 RGD
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
12057008 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to angiotensin IDA
IDA: 通过直接分析推断
15652511 RGD
involved in cellular response to endothelin IDA
IDA: 通过直接分析推断
15652511 RGD
involved in cellular response to norepinephrine stimulus IDA
IDA: 通过直接分析推断
15652511 RGD
involved in cellular response to organic cyclic compound IDA
IDA: 通过直接分析推断
16648482 RGD
involved in cellular response to organic cyclic compound IMP
IMP: 通过突变表型推断
25889640 RGD
involved in cellular response to phorbol 13-acetate 12-myristate IDA
IDA: 通过直接分析推断
15652511 RGD
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
12057008 RGD
involved in positive regulation of cell size IMP
IMP: 通过突变表型推断
16648482 RGD
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
25889640 RGD
involved in positive regulation of peptide hormone secretion IMP
IMP: 通过突变表型推断
16648482 RGD
involved in positive regulation of peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
21041300 RGD
involved in positive regulation of protein export from nucleus IMP
IMP: 通过突变表型推断
16648482 RGD
involved in positive regulation of sarcomere organization IMP
IMP: 通过突变表型推断
16648482 RGD
involved in regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril IMP
IMP: 通过突变表型推断
21041300 RGD
involved in response to norepinephrine IDA
IDA: 通过直接分析推断
16648482 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Z disc IDA
IDA: 通过直接分析推断
15652511 RGD
located in cytoplasm IDA
IDA: 通过直接分析推断
25889640 RGD
located in membrane IDA
IDA: 通过直接分析推断
15652511 RGD
located in nucleus IDA
IDA: 通过直接分析推断
16648482 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
15652511 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Prkd1 蛋白结构

C1_PKD1_rpt1

C1_PKD1_rpt1: cd20839 (137 - 208)

C1_PKD1_rpt2

C1_PKD1_rpt2: cd20842 (242 - 335)

PH_PKD

PH_PKD: cd01239 (421 - 548)

STKc_PKD

STKc_PKD: cd14082 (594 - 853)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 928 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase D1

protein kinase C mu type

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11144 PRKD1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11145 Prkd1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11146 Prkd1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Prkd1 NCBI NCBI:5587
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