2. Gene
  3. CADPS - calcium dependent secretion activator Gene

CADPS - calcium dependent secretion activator Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：钙依赖性分泌激活因子

种属: Homo sapiens

同用名: CAPS; CAPS1; CADPS1; UNC-31

基因 ID: 8618 | 基因类型: protein coding

关于 CADPS

Cytogenetic location: 3p14.2 Genomic coordinates (GRCh38): 3:62,398,348-62,875,416 (from NCBI)

This gene has 20 transcripts (splice variants) and 28 orthologues. Biased expression in brain (RPKM 14.7), adrenal (RPKM 5.4) and 9 other tissues.

功能概要

该基因编码一种新型神经/内分泌特异性细胞溶质和外周膜蛋白，这是 Ca2+ 调节的分泌小泡胞吐作用所必需的。该蛋白质在 ATP 依赖性引发后的胞吐作用阶段起作用，这涉及磷脂酰肌醇 4,5-二磷酸 (PtdIns (4,5) P2) 的基本合成。已在该位点观察到选择性剪接，并描述了编码不同亚型的三种变体。[RefSeq 提供，2008 年 8 月]

This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]

CADPS 基因产物(3)

mRNA Protein Name
NM_003716.4 NP_003707.2 calcium-dependent secretion activator 1 isoform 1
NM_183393.3 NP_899630.1 calcium-dependent secretion activator 1 isoform 3
NM_183394.3 NP_899631.1 calcium-dependent secretion activator 1 isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17984325 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CADPS 蛋白结构

DUF1041

DUF1041: Domain of Unknown Function (DUF1041) (835 - 940)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1353 a.a.
蛋白主名 其他名称

calcium-dependent secretion activator 1

CAPS-1

关联疾病

疾病名称 别名
Jejunal Somatostatinoma

Jejunal Delta Cell Somatostatin Producing Tumor

Somatosatinoma Of Jejunum

Jejunal Somatostatin-Producing Neuroendocrine Tumor
Childhood Central Nervous System Primitive Neuroectodermal Neoplasm

Pediatric Cns Pnet

Childhood Central Nervous System Primitive Neuroectodermal Tumor
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01823 CADPS Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01824 CADPS2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CADPS VGNC VGNC:26698
Felis catus CADPS VGNC VGNC:80014
Canis familiaris CADPS VGNC VGNC:38658
Rattus norvegicus CADPS RGD RGD:708573
Mus musculus CADPS MGD MGI:1350922
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