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  2. DYRK4 - dual specificity tyrosine phosphorylation regulated kinase 4 Gene

DYRK4 - dual specificity tyrosine phosphorylation regulated kinase 4 Gene

中文名称:双特异性酪氨酸磷酸化调节激酶 4

种属: Homo sapiens

基因 ID: 8798 | 基因类型: protein coding

关于 DYRK4

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:4,562,208-4,613,875 (from NCBI)

This gene has 17 transcripts (splice variants), 205 orthologues and 12 paralogues. Broad expression in testis (RPKM 18.7), thyroid (RPKM 5.2) and 23 other tissues.

功能概要

该基因编码的酶属于保守的丝氨酸/苏氨酸蛋白激酶家族。这种双重特异性激酶家族的成员被认为在细胞分化和增殖、存活和发育的调节中发挥作用。交替剪接导致多个转录本变体。已经描述了该基因的其他可变剪接转录变体,但它们的全长性质尚不清楚。[RefSeq 提供,2013 年 8 月]

This gene encodes an Enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]

DYRK4 基因产物(7)

mRNA Protein Name
NM_001282285.3 NP_001269214.1 dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 2
NM_001282286.2 NP_001269215.1 dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 3
NM_001371301.2 NP_001358230.1 dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 4
NM_001394779.1 NP_001381708.1 dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 5
NM_001394780.1 NP_001381709.1 dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 6
NM_001407019.1 NP_001393948.1 dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 1
NM_003845.3 NP_003836.1 dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22939624 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DYRK4 蛋白结构

Pkinase

Pkinase: Protein kinase domain (104 - 400)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 520 a.a.
蛋白主名 其他名称

dual specificity tyrosine-phosphorylation-regulated kinase 4

dual specificity tyrosine-(Y)-phosphorylation regulated kinase 4

DYRK4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DYRK4 Q9NR20 MID1 Homo sapiens O15344
Validated Y2H
25416956
种属内
DYRK4 Q9NR20 MID1 Homo sapiens O15344
Y2H Array
25416956
种属内
DYRK4 Q9NR20 HSP90AA1 Homo sapiens P07900
Pull Down
32707033
种属内
DYRK4 Q9NR20 HSP90AA1 Homo sapiens P07900
Lumier
25036637
种属内
DYRK4 Q9NR20 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
种属内
DYRK4 Q9NR20 DYRK2 Homo sapiens Q92630
BiFC
23602568
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Intellectual Developmental Disorder, Autosomal Dominant 7

MRD7

Mental Retardation, Autosomal Dominant 7

Autosomal Dominant Non-Syndromic Intellectual Disability 7

Dyrk1a Syndrome

Autosomal Dominant Intellectual Developmental Disorder 7

Autosomal Dominant Mental Retardation 7

Mental Retardation, Autosomal Dominant, Type 7

Abdominal Obesity-Metabolic Syndrome 3

AOMS3

Central Obesity, Type 2 Diabetes, Hypertension, And Early-Onset Coronary Artery Disease

Obesity, Abdominal, Metabolic Syndrome, Type 3

Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2

Abdominal Obesity-Metabolic Syndrome

Abdominal Obesity Metabolic Syndrome

Metabolic Syndrome X

Aoms2

Aoms1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus DYRK4 MGD MGI:1330292
Macaca mulatta DYRK4 VGNC VGNC:97761
Bos taurus DYRK4 VGNC VGNC:55903
Felis catus DYRK4 VGNC VGNC:83870
Rattus norvegicus DYRK4 RGD RGD:1306800
Others DYRK4 NCBI