DYRK2 - dual specificity tyrosine phosphorylation regulated kinase 2 Gene

中文名称：双特异性酪氨酸磷酸化调节激酶 2

种属: Homo sapiens

基因 ID: 8445 | 基因类型: protein coding

关于 DYRK2

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:67,648,745-67,665,406 (from NCBI)

This gene has 6 transcripts (splice variants), 208 orthologues and 12 paralogues. Ubiquitous expression in colon (RPKM 11.8), small intestine (RPKM 10.4) and 25 other tissues.

功能概要

DYRK2 属于蛋白激酶家族，推测其成员参与细胞生长和/或发育。该家族由其激酶结构域的结构相似性及其在酪氨酸残基上自磷酸化的能力来定义。 DYRK2 在体外证明了酪氨酸自磷酸化和组蛋白 H3 和 H2B 的催化磷酸化。已分离出两种 DYRK2 亚型。主要的亚型，亚型 1，缺少 5' 末端插入。[RefSeq 提供，2008 年 7 月]

DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]

DYRK2 基因产物(3)

mRNA	Protein	Name
XM_017020032.2	XP_016875521.1	dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X1
NM_003583.4	NP_003574.1	dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 1
NM_006482.3	NP_006473.2	dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP binding	IDA IDA: 通过直接分析推断	11311121	GOA
enables magnesium ion binding	IDA IDA: 通过直接分析推断	9748265	GOA
enables manganese ion binding	IDA IDA: 通过直接分析推断	9748265	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	23602568	GOA
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	11311121	GOA
enables protein tyrosine kinase activity	IDA IDA: 通过直接分析推断	9748265	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage response	IEP IEP: 通过表达模式推断	19965871	GOA
involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IDA IDA: 通过直接分析推断	17349958	GOA
involved in negative regulation of calcineurin-NFAT signaling cascade	IMP IMP: 通过突变表型推断	16511445	GOA
involved in positive regulation of glycogen biosynthetic process	IDA IDA: 通过直接分析推断	11311121	GOA
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	11311121	GOA
involved in smoothened signaling pathway	IMP IMP: 通过突变表型推断	18455992	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	17349958	GOA
located in nucleus	IDA IDA: 通过直接分析推断	17349958	GOA
part of ubiquitin ligase complex	IDA IDA: 通过直接分析推断	19287380	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DYRK2 蛋白结构

Pkinase

0
100
200
300
400
500
601 a.a.

蛋白主名

其他名称

dual specificity tyrosine-phosphorylation-regulated kinase 2

dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2

DYRK2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DYRK2	Q92630	YWHAE	Homo sapiens	P62258	Crosslink	36931259
种属内	DYRK2	Q92630	DYRK4	Homo sapiens	Q9NR20	Anti Tag CoIP	23602568
种属内	DYRK2	Q92630	DYRK4	Homo sapiens	Q9NR20	TAP	23602568
种属内	DYRK2	Q92630	ZBTB9	Homo sapiens	Q96C00	Validated Y2H	25416956
种属内	DYRK2	Q92630	WDR62	Homo sapiens	O43379	Y2H Prey Pooling	25416956
种属内	DYRK2	Q92630	WDR62	Homo sapiens	O43379	Validated Y2H	25416956
种属内	DYRK2	Q92630	KXD1	Homo sapiens	Q9BQD3	Y2H Array	25416956
种属内	DYRK2	Q92630	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25416956
种属内	DYRK2	Q92630	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
种属内	DYRK2	Q92630	SP100	Homo sapiens	P23497	Validated Y2H	25416956
种属内	DYRK2	Q92630	SP100	Homo sapiens	P23497	Y2H Prey Pooling	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Waardenburg Syndrome, Type 2b

Waardenburg Syndrome Type 2b	WS2B
Waardenburg Syndrome, Type Iib	Waardenburg Syndrome Type Iib

Intellectual Developmental Disorder, Autosomal Dominant 7

MRD7	Mental Retardation, Autosomal Dominant 7
Autosomal Dominant Non-Syndromic Intellectual Disability 7	Dyrk1a Syndrome
Autosomal Dominant Intellectual Developmental Disorder 7	Autosomal Dominant Mental Retardation 7
Mental Retardation, Autosomal Dominant, Type 7

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-105309	GSK-626616	Inhibitor	99.77%	否
HY-112296	T025	Inhibitor	99.64%	否
HY-U00439A	Protein kinase inhibitor 1 hydrochloride	Inhibitor	≥98.0%	否
HY-146221	Dyrk1A-IN-5	Inhibitor	98.56%	否
HY-111379	EHT 5372	Inhibitor	98.12%	否
HY-13455	LDN-192960	Inhibitor	99.56%	否
HY-110320	LDN-209929 dihydrochloride	Inhibitor	≥99.0%	否
HY-147066	Dyrk1A-IN-4	Inhibitor	99.90%	否
HY-13455A	LDN-192960 hydrochloride	Inhibitor	99.78%	否
HY-156816	ON 108600	Inhibitor	99.73%	否
HY-153949	YK-2-69	Inhibitor	99.57%	否
HY-125290	MU1210	Inhibitor	/	否
HY-162750	ZJCK-6-46	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	DYRK2	MGD	MGI:1330301
Felis catus	DYRK2	VGNC	VGNC:61687
Bos taurus	DYRK2	VGNC	VGNC:55902
Rattus norvegicus	DYRK2	RGD	RGD:1312039
Macaca mulatta	DYRK2	VGNC	VGNC:72018
Canis familiaris	DYRK2	VGNC	VGNC:40157
Others	DYRK2	NCBI

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