2. Gene
  3. SP100 - SP100 nuclear antigen Gene

SP100 - SP100 nuclear antigen Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SP100 核抗原

种属: Homo sapiens

同用名: lysp100b

基因 ID: 6672 | 基因类型: protein coding

关于 SP100

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:230,416,201-230,545,606 (from NCBI)

This gene has 19 transcripts (splice variants), 252 orthologues and 20 paralogues. Ubiquitous expression in lymph node (RPKM 13.9), bone marrow (RPKM 12.8) and 25 other tissues.

功能概要

该基因编码亚核细胞器和 PML (早幼粒细胞白血病) -SP100 核体的主要成分。 PML 和 SP100 被 SUMO-1 修饰剂共价修饰，这被认为对核体相互作用至关重要。编码的蛋白质结合异染色质蛋白，被认为在肿瘤发生、免疫和基因调控中发挥作用。已经确定了该基因的可变剪接变体；其中一个编码高迁移率基团蛋白。[RefSeq 提供，2011 年 8 月]

This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]

SP100 基因产物(6)

mRNA Protein Name
NM_001080391.2 NP_001073860.1 nuclear autoantigen Sp-100 isoform 1
NM_001206701.2 NP_001193630.1 nuclear autoantigen Sp-100 isoform 3
NM_001206702.2 NP_001193631.1 nuclear autoantigen Sp-100 isoform 4
NM_001206703.2 NP_001193632.1 nuclear autoantigen Sp-100 isoform 5
NM_001206704.2 NP_001193633.1 nuclear autoantigen Sp-100 isoform 6
NM_003113.4 NP_003104.2 nuclear autoantigen Sp-100 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
14647468 GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
11909962 GOA
enables chromo shadow domain binding IPI
IPI: 通过物理相互作用推断
9636147 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
9636146 GOA
enables kinase binding IPI
IPI: 通过物理相互作用推断
14647468 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9636146 GOA
enables protein dimerization activity IPI
IPI: 通过物理相互作用推断
9636146 GOA
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
9636147 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
9636146 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response, signal transduction by p53 class mediator IDA
IDA: 通过直接分析推断
14647468 GOA
involved in maintenance of protein location IDA
IDA: 通过直接分析推断
12470659 GOA
involved in negative regulation of DNA binding IDA
IDA: 通过直接分析推断
15247905 GOA
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
15247905 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
9636147 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
9636146 GOA
involved in negative regulation of endothelial cell migration IMP
IMP: 通过突变表型推断
15592518 GOA
involved in negative regulation of protein export from nucleus IMP
IMP: 通过突变表型推断
17245429 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15247905 GOA
involved in negative regulation of viral transcription IDA
IDA: 通过直接分析推断
16873258 GOA
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
11909962 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
11909962 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
14647468 GOA
involved in regulation of Fas signaling pathway IMP
IMP: 通过突变表型推断
17245429 GOA
involved in regulation of angiogenesis IMP
IMP: 通过突变表型推断
15592518 GOA
involved in regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
IMP: 通过突变表型推断
17245429 GOA
involved in response to cytokine IDA
IDA: 通过直接分析推断
9412458 GOA
involved in response to retinoic acid IDA
IDA: 通过直接分析推断
11313457 GOA
involved in response to type I interferon IDA
IDA: 通过直接分析推断
9230084 GOA
involved in response to type I interferon IMP
IMP: 通过突变表型推断
8810287 GOA
involved in response to type II interferon IDA
IDA: 通过直接分析推断
9230084 GOA
involved in response to type II interferon IMP
IMP: 通过突变表型推断
8810287 GOA
involved in telomere maintenance IMP
IMP: 通过突变表型推断
15767676 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Mre11 complex IDA
IDA: 通过直接分析推断
15767676 GOA
located in PML body IDA
IDA: 通过直接分析推断
9230084 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
9412458 GOA
located in nuclear periphery IDA
IDA: 通过直接分析推断
11313457 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
9973607 GOA
located in nucleolus IMP
IMP: 通过突变表型推断
11313457 GOA
located in nucleus IDA
IDA: 通过直接分析推断
2258622 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SP100 蛋白结构

HSR

HSR: HSR domain (48 - 150)

SAND

SAND: SAND domain (596 - 675)

HMG_box_2

HMG_box_2: HMG-box domain (698 - 752)

HMG_box

HMG_box: HMG (high mobility group) box (769 - 837)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 879 a.a.
蛋白主名 其他名称

nuclear autoantigen Sp-100

SP100-HMG nuclear autoantigen

SP100 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SP100 P23497 HEL25 Homo sapiens V9HWG0
Validated Y2H
25416956
种属内
SP100 P23497 HEL25 Homo sapiens V9HWG0
Y2H Array
25416956
种属内
SP100 P23497 HEL25 Homo sapiens V9HWG0
Y2H Prey Pooling
25416956
种属内
SP100 P23497 AMOTL2 Homo sapiens Q9Y2J4-4
Y2H Prey Pooling
25416956
种属内
SP100 P23497 AMOTL2 Homo sapiens Q9Y2J4-4
Y2H Array
25416956
种属内
SP100 P23497 RTP5 Homo sapiens Q14D33
Validated Y2H
25416956
种属内
SP100 P23497 q59gp6_human Homo sapiens Q59GP6
Validated Y2H
25416956
种属内
SP100 P23497 q59gp6_human Homo sapiens Q59GP6
Y2H Prey Pooling
25416956
种属内
SP100 P23497 q59gp6_human Homo sapiens Q59GP6
Y2H Array
25416956
种属内
SP100 P23497 CASP8AP2 Homo sapiens Q9UKL3
Imaging
17245429
种属内
SP100 P23497 CASP8AP2 Homo sapiens Q9UKL3
Anti Tag CoIP
17245429
种属内
SP100 P23497 SUMO3 Homo sapiens P55854
Anti Bait CoIP
17000644
种属内
SP100 P23497 ZC2HC1A Homo sapiens Q96GY0
Validated Y2H
25416956
种属内
SP100 P23497 ZC2HC1A Homo sapiens Q96GY0
Y2H Prey Pooling
25416956
种属内
SP100 P23497 RBM39 Homo sapiens Q14498-3
Validated Y2H
25416956
种属内
SP100 P23497 RBM39 Homo sapiens Q14498-3
Y2H Prey Pooling
25416956
种属内
SP100 P23497 GIPC2 Homo sapiens Q8TF65
Validated Y2H
25416956
种属内
SP100 P23497 DYRK2 Homo sapiens Q92630
Y2H Array
25416956
种属内
SP100 P23497 TRAF3IP3 Homo sapiens Q9Y228
Validated Y2H
25416956
种属内
SP100 P23497 TRAF3IP3 Homo sapiens Q9Y228
Y2H Array
25416956
种属内
SP100 P23497 ACTN2 Homo sapiens P35609
Y2H Array
31515488
种属内
SP100 P23497 ACTN2 Homo sapiens P35609
Validated Y2H
25416956
种属内
SP100 P23497 ACTN2 Homo sapiens P35609
Y2H Prey Pooling
25416956
种属内
SP100 P23497 SUMO1 Homo sapiens P63165
Validated Y2H
25416956
种属内
SP100 P23497 SUMO1 Homo sapiens P63165
Y2H Prey Pooling
25416956
种属内
SP100 P23497 SUMO1 Homo sapiens P63165
Y2H Array
25416956
种属内
SP100 P23497 SUMO1 Homo sapiens P63165
Y2H
21880768
种属内
SP100 P23497 SUMO1 Homo sapiens P63165
BiFC
25416956
种属内
SP100 P23497 SUMO1 Homo sapiens P63165
Y2H Pooling
16189514
种属内
SP100 P23497 ETS1 Homo sapiens P14921
Anti Bait CoIP
15247905
种属间
SP100 P23497 UL123 Human cytomegalovirus P03169
Anti Tag CoIP
21880768
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos
Primary Biliary Cholangitis

Primary Biliary Cirrhosis

Biliary Liver Cirrhosis

Chronic Nonsuppurative Destructive Cholangitis

Familial Primary Biliary Cirrhosis

Pbc

Hanot Syndrome

Cholestatic Cirrhosis

Biliary Cirrhosis Primary

Liver Cirrhosis, Biliary

Hanot'S Cirrhosis

Biliary Cirrhosis

Pericholangiolic Biliary Cirrhosis

Tannhauser-Magendantz Syndrome

Hanot-Rossle Syndrome

Hypertrophic Cirrhosis

Todd Cirrhosis

Hanot Cirrhosis

Charcot Cirrhosis

Mahon-Tannhauser Syndrome

Toxic Cirrhosis

Hypertrophic Biliary Cirrhosis

Monolobular Cirrhosis

Unilobar Cirrhosis

Xanthomatous Biliary Cirrhosis
Cholangitis

Acute Cholangiolitis

Ascending Cholangitis

Cholangiolitis

Cholangitis Nos

Chronic Cholangiolitis

Hepatic Duct Inflammation

Acute Cholangitis

Bile Duct Inflammation
Chronic Cholangitis
Autoimmune Cholangitis

Autoimmune Cholangiopathy
Crest Syndrome
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
Amelogenesis Imperfecta, Type Ie

Aih1

Amelogenesis Imperfecta Type 1e

AI1E

Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 1

Amelogenesis Imperfecta, Hypomaturation Type, With Snow-Capped Teeth

Enamel Hypoplasia, X-Linked

Amelogenesis Imperfecta Type Ie

Amelogenesis Imperfecta Hypoplastic/Hypomaturation X-Linked 1

Enamel Hypoplasia X-Linked

Amelogenesis Imperfecta, X-Linked 1

Amelogenesis Imperfecta, Type 1e

Amelogenesis Imperfecta Hypomaturationtype With Snow-Capped Teeth

X-Linked Amelogenesis Imperfecta 1

X-Linked Amelogenesis Imperfecta Hypoplastic/Hypomaturation 1

X-Linked Enamel Hypoplasia

Amelogenesis Imperfecta X-Linked 1

Amelogenesis Imperfecta 1e

Amelogenesis Imperfecta, Hypoplastic/Hypomaturation Type 1e

Amelogenesis Imperfecta Hypomaturation Type With Snow-Capped Teeth

Xai

X-Linked Amelogenesis Imperfecta

Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 2
Suppurative Cholangitis
Meckel Syndrome, Type 7

Meckel Syndrome 7

Nphp3-Related Meckel-Like Syndrome

MKS7

Goldston Syndrome

Meckel Syndrome Type 7

Meckel-Like Syndrome Type 1

Renal-Hepatic-Pancreatic Dysplasia-Dandy-Walker Cysts Syndrome

Renal Hepatic Pancreatic Dysplasia Dandy Walker Cyst

Renal-Hepatic-Pancreatic Dysplasia With Dandy-Walker Cyst

Meckel-Gruber Syndrome, Type 7

Dandy-Walker Cyst With Renal-Hepatic-Pancreatic Dysplasia
Viral Infectious Disease

Viral Disease

Arbovirus Infections

Virus Infection

Virus Diseases

Viral Infection

Viral Infections

Virus Infections
Sclerosing Cholangitis

Fibrosing Cholangitis

Cholangitis, Sclerosing

Primary Sclerosing Cholangitis
Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis

PSC

Sclerosing Cholangitis

Cholangitis, Sclerosing

Cholangitis Primary Sclerosing

Psc - [Primary Sclerosing Cholangitis]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-A0084 Procainamide hydrochloride ≥98.0% 否
HY-A0084A Procainamide 99.80% 否
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-A0084S Procainamide-d4 hydrochloride / 否
HY-A0084S1 Procainamide-13C2 hydrochloride / 否
HY-RS13601 SP100 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SP100 MGD MGI:109561
Rattus norvegicus SP100 RGD RGD:1359550
Canis familiaris SP100 VGNC VGNC:59095
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