2. Gene
  3. Tek - TEK receptor tyrosine kinase Gene

Tek - TEK receptor tyrosine kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Tie2; Tie-2

基因 ID: 89804 | 基因类型: protein coding

关于 Tek

功能概要

Enables growth factor binding activity. Involved in several processes, including endochondral ossification; response to cAMP; and response to estrogen. Predicted to be located in several cellular components, including basolateral plasma membrane; centriolar satellite; and microvillus. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Predicted to colocalize with actin filament and stress fiber. Biomarker of several diseases, including acute kidney tubular necrosis; brain ischemia; gastric ulcer; goiter; and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in arteriovenous malformation and multiple cutaneous and mucosal venous malformations. Orthologous to human TEK (TEK receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Tek 基因产物(1)

mRNA Protein Name
NM_001105737.1 NP_001099207.1 angiopoietin-1 receptor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables growth factor binding IPI
IPI: 通过物理相互作用推断
15714275 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in endochondral ossification IEP
IEP: 通过表达模式推断
11735002 RGD
involved in glomerulus vasculature development IMP
IMP: 通过突变表型推断
20056745 RGD
involved in positive regulation of angiogenesis IMP
IMP: 通过突变表型推断
9329972 RGD
involved in response to cAMP IEP
IEP: 通过表达模式推断
11397875 RGD
involved in response to estrogen IDA
IDA: 通过直接分析推断
11856554 RGD
involved in response to hypoxia IDA
IDA: 通过直接分析推断
11504684 RGD
involved in response to peptide hormone IEP
IEP: 通过表达模式推断
15945074 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

angiopoietin-1 receptor

TEK tyrosine kinase, endothelial

endothelial-specific receptor tyrosine kinase

tyrosine kinases that contain immunoglobulin-like loops and epidermal growth factor-similar domains 2

重组 Tek 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73438 TIE-2 Protein, Rat (HEK293, Fc) NP_001099207.1 (A23-L743) ≥95%

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-15514 Merestinib Inhibitor 99.99% Phase 2
HY-15514A Merestinib dihydrochloride Inhibitor 99.36% Phase 2
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14355 TEK Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tek NCBI NCBI:7010
Macaca fascicularis Tek NCBI NCBI:102122204
Mus musculus Tek NCBI NCBI:21687
Macaca mulatta Tek NCBI NCBI:707455
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