SLC16A3 - solute carrier family 16 member 3 Gene

中文名称：溶质载体家族 16 成员 3

种属: Homo sapiens

同用名: MCT3; MCT4; MCT 3; MCT 4; MCT-3; MCT-4

关于 SLC16A3

功能概要

质子连接的单羧酸转运蛋白 (MCT) 家族成员催化乳酸和丙酮酸跨质膜转运，该家族已被指定为溶质载体家族 16。每种 MCT 似乎具有略微不同的底物和抑制剂特异性以及转运动力学，这与其所在组织的代谢要求有关。 MCT，包括 MCT1 (SLC16A1；MIM 600682) 和 MCT2 (SLC16A7；MIM 603654) ，具有 12 个预测的跨膜结构域 (Price 等人，1998 [PubMed 9425115]) 。[OMIM 提供，2008 年 3 月]

Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked Monocarboxylate Transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008]