2. Gene
  3. MAP3K13 - mitogen-activated protein kinase kinase kinase 13 Gene

MAP3K13 - mitogen-activated protein kinase kinase kinase 13 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：丝裂原活化蛋白激酶激酶 13

种属: Homo sapiens

同用名: LZK; MLK; MEKK13

基因 ID: 9175 | 基因类型: protein coding

关于 MAP3K13

Cytogenetic location: 3q27.2 Genomic coordinates (GRCh38): 3:185,282,961-185,489,094 (from NCBI)

This gene has 15 transcripts (splice variants), 199 orthologues, 23 paralogues and is associated with 94 phenotypes. Ubiquitous expression in adrenal (RPKM 3.8), kidney (RPKM 3.4) and 25 other tissues.

功能概要

该基因编码的蛋白质是丝氨酸/苏氨酸蛋白激酶家族的成员。这种激酶包含双亮氨酸拉链基序，并已显示通过其亮氨酸拉链基序形成二聚体/寡聚体。这种激酶可以磷酸化并激活 MAPK8/JNK、MAP2K7/MKK7，这表明它在 JNK 信号通路中发挥作用。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]

MAP3K13 基因产物(3)

mRNA Protein Name
NM_001242314.2 NP_001229243.1 mitogen-activated protein kinase kinase kinase 13 isoform 1
NM_001242317.2 NP_001229246.1 mitogen-activated protein kinase kinase kinase 13 isoform 2
NM_004721.5 NP_004712.1 mitogen-activated protein kinase kinase kinase 13 isoform 1

MAP3K13 蛋白结构

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (171 - 406)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 966 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase kinase kinase 13

leucine zipper-bearing kinase

关联疾病

疾病名称 别名
Carotid Body Cancer

Cancer Of Carotid Body

Malignant Carotid Body Paraganglioma

Malignant Carotid Body Tumor

Malignant Neoplasm Of Carotid Body
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08050 MAP3K13 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus MAP3K13 VGNC VGNC:31191
Felis catus MAP3K13 VGNC VGNC:68158
Rattus norvegicus MAP3K13 RGD RGD:1561227
Mus musculus MAP3K13 MGD MGI:2444243
Canis familiaris MAP3K13 VGNC VGNC:42969
Macaca mulatta MAP3K13 VGNC VGNC:74494
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