MAP3K13 - mitogen-activated protein kinase kinase kinase 13 Gene

中文名称：丝裂原活化蛋白激酶激酶 13

种属: Homo sapiens

同用名: LZK; MLK; MEKK13

基因 ID: 9175 | 基因类型: protein coding

关于 MAP3K13

Cytogenetic location: 3q27.2 Genomic coordinates (GRCh38): 3:185,282,961-185,489,094 (from NCBI)

This gene has 15 transcripts (splice variants), 199 orthologues, 23 paralogues and is associated with 94 phenotypes. Ubiquitous expression in adrenal (RPKM 3.8), kidney (RPKM 3.4) and 25 other tissues.

功能概要

该基因编码的蛋白质是丝氨酸/苏氨酸蛋白激酶家族的成员。这种激酶包含双亮氨酸拉链基序，并已显示通过其亮氨酸拉链基序形成二聚体/寡聚体。这种激酶可以磷酸化并激活 MAPK8/JNK、MAP2K7/MKK7，这表明它在 JNK 信号通路中发挥作用。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]

MAP3K13 基因产物(3)

mRNA	Protein	Name
NM_001242314.2	NP_001229243.1	mitogen-activated protein kinase kinase kinase 13 isoform 1
NM_001242317.2	NP_001229246.1	mitogen-activated protein kinase kinase kinase 13 isoform 2
NM_004721.5	NP_004712.1	mitogen-activated protein kinase kinase kinase 13 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables IkappaB kinase complex binding	IDA IDA: 通过直接分析推断	12492477	GOA
enables MAP kinase kinase kinase activity	IDA IDA: 通过直接分析推断	11726277	GOA
enables enzyme binding	IPI IPI: 通过物理相互作用推断	12492477	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	11163770	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11726277	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	11163770	GOA
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	9353328	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in JNK cascade	IDA IDA: 通过直接分析推断	9353328	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: 通过直接分析推断	12492477	GOA
involved in protein autophosphorylation	IDA IDA: 通过直接分析推断	9353328	GOA
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	9353328	GOA
involved in stress-activated MAPK cascade	IDA IDA: 通过直接分析推断	11726277	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in membrane	IDA IDA: 通过直接分析推断	9353328	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAP3K13 蛋白结构

Pkinase_Tyr

0
200
400
600
800
966 a.a.

蛋白主名

其他名称

mitogen-activated protein kinase kinase kinase 13

leucine zipper-bearing kinase

MAP3K13 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MAP3K13	O43283	GLO1	Homo sapiens	Q04760	Y2H Array	21988832
种属内	MAP3K13	O43283	DYNC1H1	Homo sapiens	Q14204	Pull Down	32707033
种属内	MAP3K13	O43283	CDC5L	Homo sapiens	Q99459	Pull Down	32707033
种属内	MAP3K13	O43283	KLHL20	Homo sapiens	Q9Y2M5	Anti Tag CoIP	33961781
种属内	MAP3K13	O43283	FAM120A	Homo sapiens	Q9NZB2	Pull Down	32707033
种属内	MAP3K13	O43283	HADHA	Homo sapiens	P40939	Pull Down	32707033
种属内	MAP3K13	O43283	KRR1	Homo sapiens	Q13601	Pull Down	32707033
种属内	MAP3K13	O43283	INPPL1	Homo sapiens	O15357	Anti Tag CoIP	33961781
种属内	MAP3K13	O43283	CDC42	Homo sapiens	P60953	Pull Down	32707033
种属内	MAP3K13	O43283	INA	Homo sapiens	Q16352	Pull Down	32707033
种属内	MAP3K13	O43283	STAT3	Homo sapiens	P40763	Y2H Array	21988832
种属内	MAP3K13	O43283	CYFIP2	Homo sapiens	Q96F07	Pull Down	32707033
种属内	MAP3K13	O43283	MAP3K13	Homo sapiens	O43283	Anti Tag CoIP	11163770
种属内	MAP3K13	O43283	CSNK2A1	Homo sapiens	P68400	Pull Down	32707033
种属内	MAP3K13	O43283	H2AC20	Homo sapiens	Q16777	Anti Tag CoIP	33961781
种属内	MAP3K13	O43283	PRDX3	Homo sapiens	P30048	Pull Down	32707033
种属内	MAP3K13	O43283	SMC4	Homo sapiens	Q9NTJ3	Pull Down	32707033
种属内	MAP3K13	O43283	FLNC	Homo sapiens	Q14315	Pull Down	32707033
种属内	MAP3K13	O43283	COLGALT1	Homo sapiens	Q8NBJ5	Pull Down	32707033
种属内	MAP3K13	O43283	RAD50	Homo sapiens	Q92878	Pull Down	32707033
种属内	MAP3K13	O43283	MRPS35	Homo sapiens	P82673	Pull Down	32707033
种属内	MAP3K13	O43283	P4HA1	Homo sapiens	P13674	Pull Down	32707033

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Carotid Body Cancer

Cancer Of Carotid Body	Malignant Carotid Body Paraganglioma
Malignant Carotid Body Tumor	Malignant Neoplasm Of Carotid Body

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-170595	PROTAC LZK-IN-1		/	否
HY-RS08050	MAP3K13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	MAP3K13	VGNC	VGNC:31191
Felis catus	MAP3K13	VGNC	VGNC:68158
Rattus norvegicus	MAP3K13	RGD	RGD:1561227
Mus musculus	MAP3K13	MGD	MGI:2444243
Canis familiaris	MAP3K13	VGNC	VGNC:42969
Macaca mulatta	MAP3K13	VGNC	VGNC:74494

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