MAGI1 - membrane associated guanylate kinase, WW and PDZ domain containing 1 Gene

中文名称：含膜相关鸟苷酸激酶，WW 和 PDZ 结构域 1

种属: Homo sapiens

同用名: AIP3; BAP1; WWP3; AIP-3; BAP-1; BAIAP1; MAGI-1; Magi1d; TNRC19; MAGI-1b

基因 ID: 9223 | 基因类型: protein coding

关于 MAGI1

Cytogenetic location: 3p14.1 Genomic coordinates (GRCh38): 3:65,353,526-66,038,918 (from NCBI)

This gene has 18 transcripts (splice variants), 1 gene allele, 288 orthologues and 6 paralogues. Ubiquitous expression in thyroid (RPKM 5.4), brain (RPKM 4.9) and 24 other tissues.

功能概要

该基因编码的蛋白质是膜相关鸟苷酸激酶同系物 (MAGUK) 家族的成员。 MAGUK 蛋白参与细胞间接触区域质膜内表面多蛋白复合物的组装。该基因的产物可能在细胞-细胞连接处发挥支架蛋白的作用。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

MAGI1 基因产物(6)

mRNA	Protein	Name
NM_001033057.2	NP_001028229.1	membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform c
NM_001365903.2	NP_001352832.1	membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform d
NM_001365904.2	NP_001352833.1	membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform e
NM_001365905.1	NP_001352834.1	membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform f
NM_004742.3	NP_004733.2	membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform b
NM_015520.2	NP_056335.1	membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables alpha-actinin binding	IPI IPI: 通过物理相互作用推断	16464232	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9647693	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of cell-cell adhesion	IDA IDA: 通过直接分析推断	20298433	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell periphery	IDA IDA: 通过直接分析推断	20298433	GOA
located in cell projection	IDA IDA: 通过直接分析推断	16464232	GOA
located in cell-cell junction	IDA IDA: 通过直接分析推断	20298433	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	16464232	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	20298433	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAGI1 蛋白结构

Guanylate_kin

PDZ

0
300
600
900
1200
1462 a.a.

蛋白主名

其他名称

membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

BAI1-associated protein 1

MAGI1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Cross	MAGI1	Q96QZ7	E6	Human papillomavirus	P03126	SLC	22898364
Cross	MAGI1	Q96QZ7	E6	Human papillomavirus	P03126	Pull Down	12444549
Cross	MAGI1	Q96QZ7	E6	Human papillomavirus	P06463	SLC	22898364
Cross	MAGI1	Q96QZ7	E6	Human papillomavirus	P06463	Pull Down	17267502
Intra	MAGI1	Q96QZ7	FCHSD2	Homo sapiens	O94868	Pull Down	14627983
Intra	MAGI1	Q96QZ7	FCHSD2	Homo sapiens	O94868	Y2H	14627983
Intra	MAGI1	Q96QZ7	IQGAP1	Homo sapiens	P46940	Confocal	22662192
Intra	MAGI1	Q96QZ7	IQGAP1	Homo sapiens	P46940	PLA	22662192
Intra	MAGI1	Q96QZ7	KIF1B	Homo sapiens	O60333-3	Y2H	12097473
Intra	MAGI1	Q96QZ7	KIF1B	Homo sapiens	O60333-3	Pull Down	12097473
Cross	MAGI1	Q96QZ7	M	Rabies virus	P0DOF2	Phage Display	37100772

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Cervical Large Cell Neuroendocrine Carcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07981	MAGI1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	MAGI1	RGD	RGD:1586025
Macaca mulatta	MAGI1	VGNC	VGNC:74499
Bos taurus	MAGI1	VGNC	VGNC:31147
Mus musculus	MAGI1	MGD	MGI:1203522
Felis catus	MAGI1	VGNC	VGNC:69081
Canis familiaris	MAGI1	VGNC	VGNC:108248
Others	MAGI1	NCBI

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